PDB: 4939 件ウェブページステータス検索Chemie searchBIRD

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6SG4	Structure of CDK2/cyclin A M246Q, S247EN 分子名称: Cyclin-A2, Cyclin-dependent kinase 2 著者 Salamina, M, Basle, A, Massa, B, Noble, M.E.M, Endicott, J.A. 登録日 2019-08-02 公開日 2021-01-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation. J.Mol.Biol., 433, 2021
3C4W	Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.7A 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... 著者 Singh, P, Tesmer, J.J.G. 登録日 2008-01-30 公開日 2008-03-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J.Biol.Chem., 283, 2008
6T41	CDK8/Cyclin C in complex with N-(4-chlorobenzyl)isoquinolin-4-amine 分子名称: 1,2-ETHANEDIOL, Cyclin-C, Cyclin-dependent kinase 8, ... 著者 Schneider, E.V, Maskos, K, Huber, R, Kuhn, C.-D. 登録日 2019-10-11 公開日 2020-01-01 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 A precisely positioned MED12 activation helix stimulates CDK8 kinase activity. Proc.Natl.Acad.Sci.USA, 117, 2020
3C4Z	Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 1.84A 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... 著者 Singh, P, Tesmer, J.J.G. 登録日 2008-01-30 公開日 2008-03-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J.Biol.Chem., 283, 2008
6Z3U	Structure of the CAK complex form Chaetomium thermophilum 分子名称: CHLORIDE ION, CYCLIN domain-containing protein, Protein kinase domain-containing protein, ... 著者 Peissert, S, Kuper, J, Kisker, C. 登録日 2020-05-22 公開日 2020-12-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis for CDK7 activation by MAT1 and Cyclin H. Proc.Natl.Acad.Sci.USA, 117, 2020
6TD3	Structure of DDB1 bound to CR8-engaged CDK12-cyclinK 分子名称: (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Bunker, R.D, Petzold, G, Kozicka, Z, Thoma, N.H. 登録日 2019-11-07 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.46 Å) 主引用文献 The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature, 585, 2020
6RSU	TBK1 in complex with Inhibitor compound 35 分子名称: 3,3,3-tris(fluoranyl)-1-[4-[(1~{R})-1-[2-[[(2~{S})-5-(5-propan-2-yloxypyrimidin-4-yl)-2,3-dihydro-1~{H}-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]propan-1-one, Serine/threonine-protein kinase TBK1 著者 Panne, D, Hillig, R.C, Rengachari, S. 登録日 2019-05-22 公開日 2020-04-01 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Discovery of BAY-985, a Highly Selective TBK1/IKK epsilon Inhibitor. J.Med.Chem., 63, 2020
6TM5	Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A substrate at 3.9 angstrom resolution 分子名称: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... 著者 Alfieri, C, Barford, D. 登録日 2019-12-03 公開日 2020-02-19 最終更新日 2020-06-17 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase. Embo Rep., 21, 2020
3C50	Crystal Structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 2.6A 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... 著者 Singh, P, Tesmer, J.J.G. 登録日 2008-01-30 公開日 2008-03-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J.Biol.Chem., 283, 2008
3BLH	Crystal Structure of Human CDK9/cyclinT1 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cell division protein kinase 9, Cyclin-T1 著者 Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. 登録日 2007-12-11 公開日 2008-07-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
3BLR	Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol 分子名称: 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE, Cell division protein kinase 9, Cyclin-T1, ... 著者 Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. 登録日 2007-12-11 公開日 2008-07-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
3C4Y	Crystal Structure of Apo form of G protein coupled receptor kinase 1 at 7.51A 分子名称: Rhodopsin kinase 著者 Singh, P, Tesmer, J.J.G. 登録日 2008-01-30 公開日 2008-03-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (7.509 Å) 主引用文献 Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J.Biol.Chem., 283, 2008
3A62	Crystal structure of phosphorylated p70S6K1 分子名称: MANGANESE (II) ION, Ribosomal protein S6 kinase beta-1, STAUROSPORINE 著者 Sunami, T, Byrne, N, Diehl, R.E, Funabashi, K, Hall, D.L, Ikuta, M, Patel, S.B, Shipman, J.M, Smith, R.F, Takahashi, I, Zugay-Murphy, J, Iwasawa, Y, Lumb, K.J, Munshi, S.K, Sharma, S. 登録日 2009-08-18 公開日 2009-10-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J.Biol.Chem., 285, 2010
3A61	Crystal structure of unphosphorylated p70S6K1 (Form II) 分子名称: Ribosomal protein S6 kinase beta-1, STAUROSPORINE 著者 Sunami, T, Byrne, N, Diehl, R.E, Funabashi, K, Hall, D.L, Ikuta, M, Patel, S.B, Shipman, J.M, Smith, R.F, Takahashi, I, Zugay-Murphy, J, Iwasawa, Y, Lumb, K.J, Munshi, S.K, Sharma, S. 登録日 2009-08-18 公開日 2009-10-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.43 Å) 主引用文献 Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J.Biol.Chem., 285, 2010
3C51	Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 3.55A 分子名称: ADENOSINE-5'-DIPHOSPHATE, BROMIDE ION, MAGNESIUM ION, ... 著者 Singh, P, Tesmer, J.J.G. 登録日 2008-01-30 公開日 2008-03-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.55 Å) 主引用文献 Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J.Biol.Chem., 283, 2008
3C4X	Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.9A 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... 著者 Singh, P, Tesmer, J.J.G. 登録日 2008-01-30 公開日 2008-03-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J.Biol.Chem., 283, 2008
4JBV	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1268 分子名称: 1-[(1-methylpiperidin-4-yl)methyl]-3-[6-(2-methylpropoxy)naphthalen-2-yl]pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1 著者 Merritt, E.A, Larson, E.T. 登録日 2013-02-20 公開日 2014-03-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes. Eur.J.Med.Chem., 74, 2014
2C5O	Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design 分子名称: 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-AMINE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 著者 Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M. 登録日 2005-10-30 公開日 2006-03-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006
2BKZ	STRUCTURE OF CDK2-CYCLIN A WITH PHA-404611 分子名称: 1-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ... 著者 DAlessio, R, Bargiottia, A, Metz, S, Brasca, M.G, Cameron, A, Ermoli, A, Marsiglio, A, Polucci, P, Roletto, F, Tibolla, M, Vazquez, M.L, Vulpetti, A, Pevarello, P. 登録日 2005-02-23 公開日 2006-03-08 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Benzodipyrazoles: A New Class of Potent Cdk2 Inhibitors Bioorg.Med.Chem.Lett., 15, 2005
4L44	Crystal structures of human p70S6K1-T389A (form II) 分子名称: 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein, SULFATE ION, ... 著者 Wang, J, Zhong, C, Ding, J. 登録日 2013-06-07 公開日 2013-07-24 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
4L42	Crystal structures of human p70S6K1-PIF 分子名称: 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein, SULFATE ION, ... 著者 Wang, J, Zhong, C, Ding, J. 登録日 2013-06-07 公開日 2013-07-24 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
2BPM	STRUCTURE OF CDK2-CYCLIN A WITH PHA-630529 分子名称: (2S)-N-[(3Z)-5-CYCLOPROPYL-3H-PYRAZOL-3-YLIDENE]-2-[4-(2-OXOIMIDAZOLIDIN-1-YL)PHENYL]PROPANAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ... 著者 Cameron, A, Fogliatto, G, Pevarello, P, Brasca, M.G, Orsini, P, Traquandi, G, Longo, A, Nesi, M, Orzi, F, Piutti, C, Sansonna, P, Varasi, M, Vulpetti, A, Roletto, F, Alzani, R, Ciomei, M, Albanese, C, Pastori, W, Marsiglio, A, Pesenti, E, Fiorentini, F, Bischoff, J.R, Mercurio, C. 登録日 2005-04-21 公開日 2005-12-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 3-Aminopyrazole Inhibitors of Cdk2-Cyclin a as Antitumor Agents. 2. Lead Optimization J.Med.Chem., 48, 2005
4LQQ	Crystal structure of the Cbk1(T743E)-Mob2 kinase-coactivator complex in crystal form B 分子名称: CBK1 kinase activator protein MOB2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase CBK1 著者 Gogl, G, Remenyi, A. 登録日 2013-07-19 公開日 2014-07-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism. Plos Biol., 13, 2015
4MD8	Crystal Structure of full-length symmetric CK2 holoenzyme with mutated alpha subunit (F121E) 分子名称: Casein kinase II subunit alpha, Casein kinase II subunit beta, ZINC ION 著者 Lolli, G, Ranchio, A, Battistutta, R. 登録日 2013-08-22 公開日 2013-11-20 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Active Form of the Protein Kinase CK2 alpha 2 beta 2 Holoenzyme Is a Strong Complex with Symmetric Architecture. Acs Chem.Biol., 9, 2014
2C5V	Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design 分子名称: 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE, ALA-ALA-ABA-ARG-SER-LEU-ILE-PFF-NH2, CELL DIVISION PROTEIN KINASE 2, ... 著者 Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M. 登録日 2005-11-02 公開日 2006-03-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006

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