PDB: 11035 件ウェブページステータス検索Chemie searchBIRD

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5ZDO	Crystal Structure Analysis of TtQRS in co-crystallised with ATP 分子名称: CHLORIDE ION, Glutamine-tRNA ligase 著者 Mutharasappan, N, Jain, V, Sharma, A, Manickam, Y, Jeyaraman, J. 登録日 2018-02-23 公開日 2018-12-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes Int. J. Biol. Macromol., 120, 2018
7DV6	Discovery of Functionally Selective Transforming Growth Factor beta Type II Receptor (TGF-beta RII) Inhibitors as Anti-Fibrosis Agents 分子名称: 5-[(3S)-5,5-dimethyloxolan-3-yl]-6-methoxy-3-(2-methoxypyridin-4-yl)pyrazolo[1,5-a]pyrimidine, TGF-beta receptor type-2 著者 Nishihata, J, Nomura, A, Miwa, S, Doi, S, Adachi, T. 登録日 2021-01-12 公開日 2021-06-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Discovery of Selective Transforming Growth Factor beta Type II Receptor Inhibitors as Antifibrosis Agents. Acs Med.Chem.Lett., 12, 2021
6MCC	CryoEM structure of AcrIIA2 homolog in complex with CRISPR-Cas9 分子名称: Anti-CRISPR AcrIIA2 Homolog, CRISPR-associated endonuclease Cas9, Single guide RNA (116-MER) 著者 Jiang, F, Liu, J.J, Doudna, J.A. 登録日 2018-08-31 公開日 2019-01-16 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Temperature-Responsive Competitive Inhibition of CRISPR-Cas9. Mol. Cell, 73, 2019
5ZH5	CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-2 分子名称: (3S)-6,8-dihydroxy-3-{[(2R,6S)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, CHLORIDE ION, LYSINE, ... 著者 Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. 登録日 2018-03-11 公開日 2018-06-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite J. Med. Chem., 61, 2018
7E5V	Crystal structure of Phm7 in complex with inhibitor 分子名称: Diels-Alderase, GLYCEROL, SULFATE ION, ... 著者 Fujiyama, K, Kato, N, Kinugasa, K, Hino, T, Takahashi, S, Nagano, S. 登録日 2021-02-20 公開日 2021-06-30 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Molecular Basis for Two Stereoselective Diels-Alderases that Produce Decalin Skeletons*. Angew.Chem.Int.Ed.Engl., 60, 2021
7E5U	Crystal structure of Phm7 分子名称: CHLORIDE ION, Diels-Alderase, GLYCEROL, ... 著者 Fujiyama, K, Kato, N, Kinugasa, K, Hino, T, Takahashi, S, Nagano, S. 登録日 2021-02-20 公開日 2021-06-30 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Molecular Basis for Two Stereoselective Diels-Alderases that Produce Decalin Skeletons*. Angew.Chem.Int.Ed.Engl., 60, 2021
7E5T	Crystal structure of Fsa2 分子名称: Diels-Alderase fsa2, ETHANOL, PENTAETHYLENE GLYCOL, ... 著者 Fujiyama, K, Kato, N, Kinugasa, K, Hino, T, Takahashi, S, Nagano, S. 登録日 2021-02-20 公開日 2021-06-30 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.16977525 Å) 主引用文献 Molecular Basis for Two Stereoselective Diels-Alderases that Produce Decalin Skeletons*. Angew.Chem.Int.Ed.Engl., 60, 2021
6CBF	Macrophage Migration Inhibitory Factor in Complex with a Pyrazole Inhibitor (6a) 分子名称: 2-phenoxy-5-(1H-pyrazol-4-yl)benzoic acid, Macrophage migration inhibitory factor, SULFATE ION 著者 Robertson, M.J, Krimmer, S.G, Jorgensen, W.L. 登録日 2018-02-02 公開日 2018-04-04 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Optimization of Pyrazoles as Phenol Surrogates to Yield Potent Inhibitors of Macrophage Migration Inhibitory Factor. ChemMedChem, 13, 2018
6MBZ	Structure of Transcription Factor 分子名称: Signal transducer and activator of transcription 5B 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2018-08-30 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Structural and functional consequences of the STAT5BN642Hdriver mutation. Nat Commun, 10, 2019
5Z6S	Crystal structure of the PPARgamma-LBD complexed with compound DS-6930 分子名称: 3-[[6-(3,5-dimethylpyridin-2-yl)oxy-1-methyl-benzimidazol-2-yl]methoxy]benzoic acid, CHLORIDE ION, Peptide from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, ... 著者 Matsui, Y, Hanzawa, H. 登録日 2018-01-25 公開日 2018-10-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of DS-6930, a potent selective PPAR gamma modulator. Part II: Lead optimization. Bioorg. Med. Chem., 26, 2018
5D7A	Crystal structure of the kinase domain of TRAF2 and NCK-interacting protein kinase with NCB-0846 分子名称: SULFATE ION, TRAF2 and NCK-interacting protein kinase, cis-4-{[2-(1H-benzimidazol-5-ylamino)quinazolin-8-yl]oxy}cyclohexanol 著者 Ohbayashi, N, Kukimoto-Niino, M, Yamada, T, Shirouzu, M. 登録日 2015-08-13 公開日 2016-08-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 TNIK inhibition abrogates colorectal cancer stemness Nat Commun, 7, 2016
6CPJ	Solution structure of SH3 domain from Shank2 分子名称: SH3 and multiple ankyrin repeat domains protein 2 著者 Ishida, H, Vogel, H.J. 登録日 2018-03-13 公開日 2018-08-15 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution structures of the SH3 domains from Shank scaffold proteins and their interactions with Cav1.3 calcium channels. FEBS Lett., 592, 2018
6CQD	Crystal structure of HPK1 in complex with ATP analogue (AMPPNP) 分子名称: MAGNESIUM ION, Mitogen-activated protein kinase kinase kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Wu, P, Lehoux, I, Franke, Y, Mortara, K, Wang, W. 登録日 2018-03-14 公開日 2018-12-19 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer. Structure, 27, 2019
5ZH2	CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-5 分子名称: (3R)-6,8-dihydroxy-3-{[(2R,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... 著者 Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. 登録日 2018-03-11 公開日 2018-06-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite J. Med. Chem., 61, 2018
3LRS	Structure of PG16, an antibody with broad and potent neutralization of HIV-1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, PG-16 Heavy Chain Fab, PG-16 Light Chain Fab 著者 Pancera, M, Kwong, P.D. 登録日 2010-02-11 公開日 2010-06-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1. J.Virol., 84, 2010
6CKC	Structure of PRMT5:MEP50 in complex with LLY-283, a potent and selective inhibitor of PRMT5, with antitumor activity 分子名称: 7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 Antonysamy, S. 登録日 2018-02-27 公開日 2018-05-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Med Chem Lett, 9, 2018
5ZDL	Crystal Structure Analysis of TtQRS in co-crystallised with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Glutamine--tRNA ligase 著者 Mutharasappan, N, Jain, V, Sharma, A, Manickam, Y, Jeyaraman, J. 登録日 2018-02-23 公開日 2018-12-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes Int. J. Biol. Macromol., 120, 2018
5ZKE	Crystal Structure of N-terminal Domain of Plasmodium vivax p43 in space group P212121 分子名称: Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein p43 著者 Gupta, S, Sharma, M, Harlos, K, Manickam, Y, Sharma, A. 登録日 2018-03-23 公開日 2019-04-24 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.492 Å) 主引用文献 Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein. Acta Crystallogr D Struct Biol, 76, 2020
5ZKF	Crystal Structure of N-terminal Domain of Plasmodium vivax p43 in space group P21 分子名称: Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein p43 著者 Gupta, S, Sharma, M, Harlos, K, Manickam, Y, Sharma, A. 登録日 2018-03-23 公開日 2019-04-24 最終更新日 2020-03-11 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein. Acta Crystallogr D Struct Biol, 76, 2020
5DRW	Crystal structure of the BCR Fab fragment from subset #4 case CLL183 分子名称: CLL183 BCR antibody heavy chain, CLL183 BCR antibody light chain 著者 Minici, C, Degano, M. 登録日 2015-09-16 公開日 2016-09-28 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia. Nat Commun, 8, 2017
6CQF	Crystal structure of HPK1 in complex an inhibitor G1858 分子名称: Mitogen-activated protein kinase kinase kinase kinase 1, N-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3R)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-pyrazolo[4,3-c]pyridin-6-amine 著者 Wu, P, Lehoux, I, Mortara, K, Franke, Y, Chan, B.K, Wang, W. 登録日 2018-03-15 公開日 2018-12-19 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.246 Å) 主引用文献 Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer. Structure, 27, 2019
5ZS9	SufS from Bacillus subtilis in the resting state 分子名称: Cysteine desulfurase SufS, DI(HYDROXYETHYL)ETHER 著者 Nakamura, R, Fujishiro, T, Takahashi, Y. 登録日 2018-04-28 公開日 2019-05-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Snapshots of PLP-substrate and PLP-product external aldimines as intermediates in two types of cysteine desulfurase enzymes. Febs J., 287, 2020
5B1M	The mouse nucleosome structure containing H3.1 分子名称: DNA (146-MER), Histone H2A type 1, Histone H2B type 3-A, ... 著者 Urahama, T, Machida, S, Horikoshi, N, Osakabe, A, Tachiwana, H, Taguchi, H, Kurumizaka, H. 登録日 2015-12-08 公開日 2017-02-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis Cell Rep, 18, 2017
5AYF	Crystal structure of SET7/9 in complex with cyproheptadine 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(dibenzo[1,2-a:2',1'-d][7]annulen-11-ylidene)-1-methyl-piperidine, Histone-lysine N-methyltransferase SETD7, ... 著者 Niwa, H, Handa, N, Takemoto, Y, Ito, A, Tomabechi, Y, Umehara, T, Shirouzu, M, Yoshida, M, Yokoyama, S. 登録日 2015-08-20 公開日 2016-04-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.005 Å) 主引用文献 Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription J.Med.Chem., 59, 2016
6AAG	Crystal structure of budding yeast Atg8 complexed with the helical AIM of Hfl1. 分子名称: Transmembrane protein 184 homolog YKR051W,Autophagy-related protein 8 著者 Yamasaki, A, Noda, N.N. 登録日 2018-07-18 公開日 2018-12-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.445 Å) 主引用文献 Lipidation-independent vacuolar functions of Atg8 rely on its noncanonical interaction with a vacuole membrane protein Elife, 7, 2018

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