5ZH5
CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-2
Summary for 5ZH5
Entry DOI | 10.2210/pdb5zh5/pdb |
Descriptor | Lysine--tRNA ligase, LYSINE, (3S)-6,8-dihydroxy-3-{[(2R,6S)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, ... (4 entities in total) |
Functional Keywords | krs, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Plasmodium falciparum NF54 (Plasmodium falciparum (isolate NF54)) |
Total number of polymer chains | 2 |
Total formula weight | 118328.36 |
Authors | Babbar, P.,Malhotra, N.,Sharma, M.,Harlos, K.,Reddy, D.S.,Manickam, Y.,Sharma, A. (deposition date: 2018-03-11, release date: 2018-06-27, Last modification date: 2023-11-22) |
Primary citation | Das, P.,Babbar, P.,Malhotra, N.,Sharma, M.,Jachak, G.R.,Gonnade, R.G.,Shanmugam, D.,Harlos, K.,Yogavel, M.,Sharma, A.,Reddy, D.S. Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite J. Med. Chem., 61:5664-5678, 2018 Cited by PubMed: 29779382DOI: 10.1021/acs.jmedchem.8b00565 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.08 Å) |
Structure validation
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