6XDB
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![BU of 6xdb by Molmil](/molmil-images/mine/6xdb) | Crystal structure of IRE1a in complex with G-6904 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-amino-N-(6-chloro-2-fluoro-3-{[(2-fluorophenyl)sulfonyl]amino}phenyl)-6-(1,3-dimethyl-1H-pyrazol-4-yl)quinazoline-8-carboxamide, Serine/threonine-protein kinase/endoribonuclease IRE1 | 著者 | Wallweber, H.A, Weiru, W. | 登録日 | 2020-06-10 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1 alpha Inhibitory Activity. Acs Med.Chem.Lett., 11, 2020
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6XDF
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![BU of 6xdf by Molmil](/molmil-images/mine/6xdf) | Crystal structure of IRE1a in complex with G-4100 | 分子名称: | 4-amino-N-(6-chloro-2-fluoro-3-{[(pyrrolidin-1-yl)sulfonyl]amino}phenyl)quinazoline-8-carboxamide, SODIUM ION, Serine/threonine-protein kinase/endoribonuclease IRE1 | 著者 | Steinbacher, S, Wang, W. | 登録日 | 2020-06-10 | 公開日 | 2021-04-21 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1 alpha Inhibitory Activity. Acs Med.Chem.Lett., 11, 2020
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6XDD
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![BU of 6xdd by Molmil](/molmil-images/mine/6xdd) | Crystal structure of IRE1 in complex with G-3053 | 分子名称: | 4-[(trans-4-aminocyclohexyl)amino]-N-(6-chloro-3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)thieno[3,2-d]pyrimidine-7-carboxamide, Serine/threonine-protein kinase/endoribonuclease IRE1 | 著者 | Ackerly-Wallweber, H, Wang, W. | 登録日 | 2020-06-10 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1 alpha Inhibitory Activity. Acs Med.Chem.Lett., 11, 2020
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6XI8
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![BU of 6xi8 by Molmil](/molmil-images/mine/6xi8) | Yeast TFIIK (Kin28/Ccl1/Tfb3) Complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Cyclin CCL1, ... | 著者 | van Eeuwen, T, Murakami, K, Li, T, Tsai, K.L. | 登録日 | 2020-06-19 | 公開日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | Structure of TFIIK for phosphorylation of CTD of RNA polymerase II. Sci Adv, 7, 2021
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6RIJ
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6RST
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![BU of 6rst by Molmil](/molmil-images/mine/6rst) | TBK1 in complex with inhibitor compound 24 | 分子名称: | 1-[4-[(1~{R})-1-[2-[[5-[1-(cyclopropylmethyl)pyrazol-4-yl]-1~{H}-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]-3,3,3-tris(fluoranyl)propan-1-one, Serine/threonine-protein kinase TBK1 | 著者 | Panne, D, Hillig, R.C, Rengachari, S. | 登録日 | 2019-05-22 | 公開日 | 2020-01-01 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | 主引用文献 | Discovery of BAY-985, a Highly Selective TBK1/IKK epsilon Inhibitor. J.Med.Chem., 63, 2020
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3A8W
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![BU of 3a8w by Molmil](/molmil-images/mine/3a8w) | Crystal Structure of PKCiota kinase domain | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Protein kinase C iota type, SULFATE ION | 著者 | Takimura, T, Kamata, K. | 登録日 | 2009-10-11 | 公開日 | 2010-05-05 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structures of the PKC-iota kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533-551 in the C-terminal tail and their roles in ATP binding Acta Crystallogr.,Sect.D, 66, 2010
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6YA6
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![BU of 6ya6 by Molmil](/molmil-images/mine/6ya6) | Minimal construct of Cdc7-Dbf4 bound to XL413 | 分子名称: | 8-chloro-2-[(2S)-pyrrolidin-2-yl][1]benzofuro[3,2-d]pyrimidin-4(3H)-one, BORIC ACID, CHLORIDE ION, ... | 著者 | Dick, S.D, Cherepanov, P. | 登録日 | 2020-03-11 | 公開日 | 2020-05-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | 主引用文献 | Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase. Structure, 28, 2020
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6YA7
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![BU of 6ya7 by Molmil](/molmil-images/mine/6ya7) | Cdc7-Dbf4 bound to an Mcm2-S40 derived bivalent substrate | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase, DNA replication licensing factor MCM2, ... | 著者 | Dick, S.D, Cherepanov, P. | 登録日 | 2020-03-11 | 公開日 | 2020-05-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase. Structure, 28, 2020
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6S9W
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![BU of 6s9w by Molmil](/molmil-images/mine/6s9w) | |
6S9X
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3A8X
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![BU of 3a8x by Molmil](/molmil-images/mine/3a8x) | Crystal Structure of PKCiota kinase domain | 分子名称: | Protein kinase C iota type, SULFATE ION | 著者 | Takimura, T, Kamata, K. | 登録日 | 2009-10-11 | 公開日 | 2010-05-05 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of the PKC-iota kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533-551 in the C-terminal tail and their roles in ATP binding Acta Crystallogr.,Sect.D, 66, 2010
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3A60
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![BU of 3a60 by Molmil](/molmil-images/mine/3a60) | Crystal structure of unphosphorylated p70S6K1 (Form I) | 分子名称: | Ribosomal protein S6 kinase beta-1, STAUROSPORINE | 著者 | Sunami, T, Byrne, N, Diehl, R.E, Funabashi, K, Hall, D.L, Ikuta, M, Patel, S.B, Shipman, J.M, Smith, R.F, Takahashi, I, Zugay-Murphy, J, Iwasawa, Y, Lumb, K.J, Munshi, S.K, Sharma, S. | 登録日 | 2009-08-17 | 公開日 | 2009-10-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J.Biol.Chem., 285, 2010
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6YA8
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![BU of 6ya8 by Molmil](/molmil-images/mine/6ya8) | Cdc7-Dbf4 bound to ADP-BeF3 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase, ... | 著者 | Dick, S.D, Cherepanov, P. | 登録日 | 2020-03-11 | 公開日 | 2020-05-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase. Structure, 28, 2020
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3BHV
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![BU of 3bhv by Molmil](/molmil-images/mine/3bhv) | Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor variolin B | 分子名称: | 9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol, Cell division protein kinase 2, Cyclin-A2, ... | 著者 | Echalier, A, Bettayeb, K, Ferandin, Y, Lozach, O, Clement, M, Valette, A, Liger, F, Marquet, B, Morris, J.C, Endicott, J.A, Joseph, B, Meijer, L. | 登録日 | 2007-11-29 | 公開日 | 2008-02-12 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases Cancer Res., 67, 2007
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6XD3
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![BU of 6xd3 by Molmil](/molmil-images/mine/6xd3) | Structure of the human CAK in complex with THZ1 | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Greber, B.J, Perez-Bertoldi, J.M, Lim, K, Iavarone, A.T, Toso, D.B, Nogales, E. | 登録日 | 2020-06-09 | 公開日 | 2020-09-09 | 最終更新日 | 2020-09-30 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | The cryoelectron microscopy structure of the human CDK-activating kinase. Proc.Natl.Acad.Sci.USA, 117, 2020
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6Y0A
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![BU of 6y0a by Molmil](/molmil-images/mine/6y0a) | |
3BHT
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![BU of 3bht by Molmil](/molmil-images/mine/3bht) | Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 3 | 分子名称: | 4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine, Cell division protein kinase 2, Cyclin-A2, ... | 著者 | Echalier, A, Bettayeb, K, Ferandin, Y, Lozach, O, Clement, M, Valette, A, Liger, F, Marquet, B, Morris, J.C, Endicott, J.A, Joseph, B, Meijer, L. | 登録日 | 2007-11-29 | 公開日 | 2008-02-12 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases Cancer Res., 67, 2007
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6XR4
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6R3S
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![BU of 6r3s by Molmil](/molmil-images/mine/6r3s) | CRYSTAL STRUCTURE OF CDK8-CycC IN COMPLEX WITH COMPOUND 1 | 分子名称: | 1,2-ETHANEDIOL, 6-[5-chloranyl-4-[(1~{S})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{H}-1,8-naphthyridine-1-carboxamide, Cyclin-C, ... | 著者 | Boettcher, J. | 登録日 | 2019-03-21 | 公開日 | 2020-04-08 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol.Cancer Ther., 19, 2020
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3BEG
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![BU of 3beg by Molmil](/molmil-images/mine/3beg) | Crystal structure of SR protein kinase 1 complexed to its substrate ASF/SF2 | 分子名称: | ALANINE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PHOSPHOSERINE, ... | 著者 | Ngo, J.C, Giang, K, Chakrabarti, S, Ma, C.-T, Huynh, N, Hagopian, J, Dorrestein, P.C, Fu, X.-D, Adams, J.A, Ghosh, G. | 登録日 | 2007-11-18 | 公開日 | 2008-04-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A sliding docking interaction is essential for sequential and
processive phosphorylation of an SR protein by SRPK1 Mol.Cell, 29, 2008
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3BHU
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![BU of 3bhu by Molmil](/molmil-images/mine/3bhu) | Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 5 | 分子名称: | 4-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine, Cell division protein kinase 2, Cyclin-A2, ... | 著者 | Echalier, A, Bettayeb, K, Ferandin, Y, Lozach, O, Clement, M, Valette, A, Liger, F, Marquet, B, Morris, J.C, Endicott, J.A, Joseph, B, Meijer, L. | 登録日 | 2007-11-29 | 公開日 | 2008-02-12 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases Cancer Res., 67, 2007
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3BLQ
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![BU of 3blq by Molmil](/molmil-images/mine/3blq) | Crystal Structure of Human CDK9/cyclinT1 in Complex with ATP | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Cell division protein kinase 9, ... | 著者 | Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. | 登録日 | 2007-12-11 | 公開日 | 2008-07-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
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6Z45
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![BU of 6z45 by Molmil](/molmil-images/mine/6z45) | CDK9-Cyclin-T1 complex bound by compound 24 | 分子名称: | (1~{S},3~{R})-3-acetamido-~{N}-[5-chloranyl-4-(5,5-dimethyl-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl]cyclohexane-1-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cyclin-T1, ... | 著者 | Ferguson, A, Collie, G.W. | 登録日 | 2020-05-22 | 公開日 | 2020-12-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.37 Å) | 主引用文献 | Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies. J.Med.Chem., 63, 2020
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6Z4X
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![BU of 6z4x by Molmil](/molmil-images/mine/6z4x) | Structure of the CAK complex form Chaetomium thermophilum bound to ATP-gamma-S | 分子名称: | CHLORIDE ION, CYCLIN domain-containing protein, MAGNESIUM ION, ... | 著者 | Peissert, S, Kuper, J, Kisker, C. | 登録日 | 2020-05-26 | 公開日 | 2020-12-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Structural basis for CDK7 activation by MAT1 and Cyclin H. Proc.Natl.Acad.Sci.USA, 117, 2020
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