PDB: 2718 件ウェブページステータス検索Chemie searchBIRD

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2ZEU	S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with BPH-715 分子名称: 3-(DECYLOXY)-1-(2,2-DIPHOSPHONOETHYL)PYRIDINIUM, Geranylgeranyl pyrophosphate synthetase 著者 Guo, R.T, Chen, C.K.-M, Cao, R, Oldfield, E, Wang, A.H.-J. 登録日 2007-12-17 公開日 2008-12-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation J.Am.Chem.Soc., 131, 2009
3G2I	Crystal structure of 1-(beta-D-glucopyranosyl)-4-substituted-1,2,3-triazole 分子名称: 1-beta-D-glucopyranosyl-4-(hydroxymethyl)-1H-1,2,3-triazole, Glycogen phosphorylase, muscle form 著者 Chrysina, E.D, Bokor, E, Alexacou, K.-M, Charavgi, M.-D, Oikonomakos, G.N, Zographos, S.E, Leonidas, D.D, Oikonomakos, N.G, Somsak, L. 登録日 2009-01-31 公開日 2010-02-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case Tetrahedron: Asymmetry, 20, 2009
4I1B	FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE 分子名称: INTERLEUKIN-1 BETA 著者 Veerapandian, B, Poulos, T.L, Gilliland, G.L, Raag, R, Svensson, L.A, Masui, Y, Hirai, Y. 登録日 1990-03-27 公開日 1990-04-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Functional implications of interleukin-1 beta based on the three-dimensional structure. Proteins, 12, 1992
1FZV	THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, PLACENTA GROWTH FACTOR 著者 Iyer, S, Leonidas, D.D, Swaminathan, G.J, Maglione, D, Battisti, M, Tucci, M, Persico, M.G, Acharya, K.R. 登録日 2000-10-04 公開日 2001-05-09 最終更新日 2022-12-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution. J.Biol.Chem., 276, 2001
3ZCT	Rabbit muscle glycogen phosphorylase b in complex with N-(2-naphthoyl) -N-beta-D-glucopyranosyl urea determined at 2.0 A resolution 分子名称: GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, INOSINIC ACID, ... 著者 Chrysina, E.D, Nagy, V, Felfoldi, N, Konya, B, Telepo, K, Praly, J.P, Docsa, T, Gergely, P, Alexacou, K.M, Hayes, J.M, Konstantakaki, M, Kardakaris, R, Leonidas, D.D, Zographos, S.E, Oikonomakos, N.G, Somsak, L. 登録日 2012-11-21 公開日 2013-12-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Synthesis, Kinetic, Computational and Crystallographic Evaluation of N-Acyl-N-Beta-D- Glucopyranosyl)Ureas, Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase, Potential Antidiabetic Agents To be Published
6KD7	Crystal structure of geranylgeranyl pyrophosphate synthase 分子名称: GLYCEROL, MAGNESIUM ION, PYROPHOSPHATE, ... 著者 Kim, S, Kim, K.-J. 登録日 2019-07-01 公開日 2019-09-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of geranylgeranyl pyrophosphate synthase (crtE) from Nonlabens dokdonensis DSW-6. Biochem.Biophys.Res.Commun., 518, 2019
4GP2	Crystal structure of ISOPRENOID SYNTHASE A3MSH1 (TARGET EFI-501992) from pyrobaculum calidifontis complexed with DMAPP and Magnesium 分子名称: DIMETHYLALLYL DIPHOSPHATE, MAGNESIUM ION, Polyprenyl synthetase 著者 Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Poulter, C.D, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) 登録日 2012-08-20 公開日 2012-10-10 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of Isoprenoid Synthase from Pyrobaculum Calidifontis To be Published
3MT7	Glycogen phosphorylase complexed with 4-bromobenzaldehyde-4-(beta-D-glucopyranosyl)-thiosemicarbazone 分子名称: Glycogen phosphorylase, muscle form, N-({(2E)-2-[(4-bromophenyl)methylidene]hydrazino}carbonothioyl)-beta-D-glucopyranosylamine 著者 Alexacou, K.-M. 登録日 2010-04-30 公開日 2011-01-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors Bioorg.Med.Chem., 18, 2010
2GPA	ALLOSTERIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG 分子名称: GLYCEROL, PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE, ... 著者 Oikonomakos, N.G, Tsitsanou, K.E, Zographos, S.E, Skamnaki, V.T. 登録日 1999-02-18 公開日 1999-02-26 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate. Protein Sci., 8, 1999
6N7Y	Crystal structure of human FPPS in complex with an allosteric inhibitor MIT-01-102 分子名称: Farnesyl pyrophosphate synthase, GLYCEROL, PHOSPHATE ION, ... 著者 Park, J, Berghuis, A.M. 登録日 2018-11-28 公開日 2019-11-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS). J.Med.Chem., 62, 2019
6N83	Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037 分子名称: CHLORIDE ION, Farnesyl pyrophosphate synthase, PHOSPHATE ION, ... 著者 Park, J, Schilling, M.A, Berghuis, A.M. 登録日 2018-11-28 公開日 2019-11-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS). J.Med.Chem., 62, 2019
31BI	INTERLEUKIN-1 BETA (IL-1 BETA) (MUTANT WITH CYS 71 REPLACED BY SER) (C71S) 分子名称: INTERLEUKIN-1 BETA PRECURSOR 著者 Veerapandian, B, Poulos, T.L, Gilliland, G.L, Masui, Y, Hirai, Y. 登録日 1991-03-21 公開日 1992-04-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献
3EBP	Glycogen Phosphorylase b/flavopiridol complex 分子名称: 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE, Glycogen phosphorylase, muscle form 著者 Oikonomakos, N.G, Zographos, S.E, Leonidas, D.D, Hayes, J.M, Tiraidis, C, Alexacou, K.-M. 登録日 2008-08-28 公開日 2009-09-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: Comparison of chrysin and flavopiridol Food Chem.Toxicol., 61, 2013
4FP4	Crystal structure of isoprenoid synthase a3mx09 (target efi-501993) from pyrobaculum calidifontis 分子名称: GERAN-8-YL GERAN, Polyprenyl synthetase, UNKNOWN ATOM OR ION, ... 著者 Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Poulter, C.D, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) 登録日 2012-06-21 公開日 2012-07-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA, 110, 2013
3F62	Crystal Structure of Human IL-18 in complex with Ectromelia virus IL-18 Binding Protein 分子名称: Interleukin 18 binding protein, Interleukin-18 著者 Krumm, B.E, Li, Y, Deng, J. 登録日 2008-11-05 公開日 2009-01-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for antagonism of human interleukin 18 by poxvirus interleukin 18-binding protein. Proc.Natl.Acad.Sci.USA, 105, 2008
1IOB	INTERLEUKIN-1 BETA FROM JOINT X-RAY AND NMR REFINEMENT 分子名称: INTERLEUKIN-1 BETA 著者 Shaanan, B, Clore, G.M. 登録日 1996-03-14 公開日 1996-08-17 最終更新日 2024-05-01 実験手法 SOLUTION NMR (2 Å), X-RAY DIFFRACTION 主引用文献 Combining experimental information from crystal and solution studies: joint X-ray and NMR refinement. Science, 257, 1992
3GEW	FaeE-FaeG chaperone-major pilin complex of F4 ad fimbriae 分子名称: Chaperone protein faeE, GLYCEROL, K88 fimbrial protein AD, ... 著者 Van Molle, I, Moonens, K, Garcia-Pino, A, Buts, L, Bouckaert, J, De Greve, H. 登録日 2009-02-26 公開日 2009-10-20 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and thermodynamic characterization of pre- and postpolymerization states in the F4 fimbrial subunit FaeG J.Mol.Biol., 394, 2009
3UCA	Crystal structure of isoprenoid synthase (target EFI-501974) from clostridium perfringens 分子名称: Geranyltranstransferase 著者 Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Poulter, C.D, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) 登録日 2011-10-26 公開日 2011-11-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA, 110, 2013
4LFV	Crystal structure of human FPPS in complex with YS0470 and two molecules of inorganic phosphate 分子名称: CHLORIDE ION, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... 著者 Park, J, Lin, Y.-S, Tsantrizos, Y.S, Berghuis, A.M. 登録日 2013-06-27 公開日 2014-03-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate. Acta Crystallogr F Struct Biol Commun, 70, 2014
1XTB	Crystal Structure of Rabbit Phosphoglucose Isomerase Complexed with Sorbitol-6-Phosphate 分子名称: D-SORBITOL-6-PHOSPHATE, phosphoglucose isomerase 著者 Lee, J.H, Jeffery, C.J. 登録日 2004-10-21 公開日 2005-03-22 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The crystal structure of rabbit phosphoglucose isomerase complexed with D-sorbitol-6-phosphate, an analog of the open chain form of D-glucose-6-phosphate. Protein Sci., 14, 2005
3EGT	T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-722 分子名称: 1-(2,2-diphosphonoethyl)-3-(heptyloxy)pyridinium, Farnesyl pyrophosphate synthase, MAGNESIUM ION 著者 Cao, R, Gao, Y, Robinson, H, Oldfield, E. 登録日 2008-09-11 公開日 2009-05-05 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J.Am.Chem.Soc., 131, 2009
2I1B	CRYSTALLOGRAPHIC REFINEMENT OF INTERLEUKIN-1 BETA AT 2.0 ANGSTROMS RESOLUTION 分子名称: INTERLEUKIN-1 BETA 著者 Priestle, J.P, Schaer, H.-P, Gruetter, M.G. 登録日 1990-01-02 公開日 1990-04-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystallographic refinement of interleukin 1 beta at 2.0 A resolution. Proc.Natl.Acad.Sci.USA, 86, 1989
2OGD	T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-527 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, BETA-MERCAPTOETHANOL, ... 著者 Cao, R, Gao, Y, Robinson, H, Goddard, A, Oldfield, E. 登録日 2007-01-05 公開日 2007-10-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Bisphosphonates: Teaching Old Drugs with New Tricks TO BE PUBLISHED
4QS7	Arabidopsis Hexokinase 1 (AtHXK1) structure in glucose-bound form 分子名称: Hexokinase-1, beta-D-glucopyranose 著者 Feng, J, Zhao, S, Liu, L. 登録日 2014-07-03 公開日 2015-02-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.001 Å) 主引用文献 Biochemical and structural study of Arabidopsis hexokinase 1 Acta Crystallogr.,Sect.D, 71, 2015
5XN5	Homo-dimer crystal structure of geranylgeranyl diphosphate synthases 1 from Oryza sativa 分子名称: Os07g0580900 protein 著者 Wang, C, Zhou, F, Lu, S, Zhang, P. 登録日 2017-05-18 公開日 2017-06-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.002 Å) 主引用文献 A recruiting protein of geranylgeranyl diphosphate synthase controls metabolic flux toward chlorophyll biosynthesis in rice Proc. Natl. Acad. Sci. U.S.A., 114, 2017

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