3ZCT

Rabbit muscle glycogen phosphorylase b in complex with N-(2-naphthoyl) -N-beta-D-glucopyranosyl urea determined at 2.0 A resolution

Summary for 3ZCT

• Entry DOI: 10.2210/pdb3zct/pdb
• Related: 3ZCP 3ZCQ 3ZCR 3ZCS 3ZCU 3ZCV
• Descriptor: GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, PYRIDOXAL-5'-PHOSPHATE, N-[[(2R,3R,4S,5S,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]carbamoyl]naphthalene-2-carboxamide, ... (5 entities in total)
• Functional Keywords: transferase, inhibitor, hypoglycaemic agents, structure-based ligand design
• Biological source: ORYCTOLAGUS CUNICULUS (RABBIT)
• Total number of polymer chains: 1
• Total formula weight: 98770.47

Authors

Chrysina, E.D.,Nagy, V.,Felfoldi, N.,Konya, B.,Telepo, K.,Praly, J.P.,Docsa, T.,Gergely, P.,Alexacou, K.M.,Hayes, J.M.,Konstantakaki, M.,Kardakaris, R.,Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G.,Somsak, L. (deposition date: 2012-11-21, release date: 2013-12-11, Last modification date: 2023-12-20)

• Primary citation: Chrysina, E.D.,Nagy, V.,Felfoldi, N.,Konya, B.,Telepo, K.,Praly, J.P.,Docsa, T.,Gergely, P.,Alexacou, K.M.,Hayes, J.M.,Konstantakaki, M.,Kardakaris, R.,Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G.,Somsak, L.; Synthesis, Kinetic, Computational and Crystallographic Evaluation of N-Acyl-N-Beta-D- Glucopyranosyl)Ureas, Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase, Potential Antidiabetic Agents; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)