8F7W
| Gi bound kappa-opioid receptor in complex with dynorphin | 分子名称: | CHOLESTEROL, Dynorphin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | 登録日 | 2022-11-20 | 公開日 | 2022-12-14 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Structures of the entire human opioid receptor family. Cell, 186, 2023
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8F7S
| Gi bound delta-opioid receptor in complex with deltorphin | 分子名称: | CHOLESTEROL, Delta-type opioid receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | 登録日 | 2022-11-20 | 公開日 | 2022-12-14 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structures of the entire human opioid receptor family. Cell, 186, 2023
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8F7R
| Gi bound mu-opioid receptor in complex with endomorphin | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | 登録日 | 2022-11-20 | 公開日 | 2022-12-14 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Structures of the entire human opioid receptor family. Cell, 186, 2023
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8F7Q
| Gi bound mu-opioid receptor in complex with beta-endorphin | 分子名称: | Beta-endorphin, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | 登録日 | 2022-11-20 | 公開日 | 2022-12-14 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Structures of the entire human opioid receptor family. Cell, 186, 2023
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8EJK
| Structure of FFAR1-Gq complex bound to TAK-875 in a lipid nanodisc | 分子名称: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | 登録日 | 2022-09-17 | 公開日 | 2023-05-24 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Molecular mechanism of fatty acid activation of FFAR1. Proc.Natl.Acad.Sci.USA, 120, 2023
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8EJC
| Structure of FFAR1-Gq complex bound to TAK-875 | 分子名称: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | 登録日 | 2022-09-16 | 公開日 | 2023-05-24 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular mechanism of fatty acid activation of FFAR1. Proc.Natl.Acad.Sci.USA, 120, 2023
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8EIT
| Structure of FFAR1-Gq complex bound to DHA | 分子名称: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 1, ... | 著者 | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | 登録日 | 2022-09-15 | 公開日 | 2023-05-24 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Molecular mechanism of fatty acid activation of FFAR1. Proc.Natl.Acad.Sci.USA, 120, 2023
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8EFQ
| DAMGO-bound mu-opioid receptor-Gi complex | 分子名称: | DAMGO, ETHANOLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | 登録日 | 2022-09-08 | 公開日 | 2022-11-09 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor. Cell, 185, 2022
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8EFO
| PZM21-bound mu-opioid receptor-Gi complex | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | 登録日 | 2022-09-08 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor. Cell, 185, 2022
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8EFL
| SR17018-bound mu-opioid receptor-Gi complex | 分子名称: | 5,6-dichloro-1-{1-[(4-chlorophenyl)methyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | 登録日 | 2022-09-08 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor. Cell, 185, 2022
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8EFB
| Oliceridine-bound mu-opioid receptor-Gi complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | 登録日 | 2022-09-08 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor. Cell, 185, 2022
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8EF6
| Morphine-bound mu-opioid receptor-Gi complex | 分子名称: | (7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | 登録日 | 2022-09-08 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor. Cell, 185, 2022
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8EF5
| Fentanyl-bound mu-opioid receptor-Gi complex | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | 登録日 | 2022-09-08 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor. Cell, 185, 2022
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8EA0
| CryoEM structure of miniGq-coupled hM3R in complex with iperoxo (local refinement) | 分子名称: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, CHOLESTEROL HEMISUCCINATE, Muscarinic acetylcholine receptor M3 | 著者 | Zhang, S, Fay, J.F, Roth, B.L. | 登録日 | 2022-08-27 | 公開日 | 2022-11-30 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (2.56 Å) | 主引用文献 | Molecular basis for selective activation of DREADD-based chemogenetics. Nature, 612, 2022
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8E9Z
| CryoEM structure of miniGq-coupled hM3R in complex with Iperoxo | 分子名称: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhang, S, Fay, J.F, Roth, B.L. | 登録日 | 2022-08-27 | 公開日 | 2022-11-30 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | 主引用文献 | Molecular basis for selective activation of DREADD-based chemogenetics. Nature, 612, 2022
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8E9Y
| CryoEM structure of miniGq-coupled hM3Dq in complex with CNO | 分子名称: | 8-chloro-11-(4-methyl-4-oxo-4lambda~5~-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, S, Fay, J.F, Roth, B.L. | 登録日 | 2022-08-27 | 公開日 | 2022-11-30 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Molecular basis for selective activation of DREADD-based chemogenetics. Nature, 612, 2022
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8E9X
| CryoEM structure of miniGo-coupled hM4Di in complex with DCZ | 分子名称: | 11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, S, Fay, J.F, Roth, B.L. | 登録日 | 2022-08-27 | 公開日 | 2022-11-30 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Molecular basis for selective activation of DREADD-based chemogenetics. Nature, 612, 2022
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8E9W
| CryoEM structure of miniGq-coupled hM3Dq in complex with DCZ | 分子名称: | 11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, S, Fay, J.F, Roth, B.L. | 登録日 | 2022-08-27 | 公開日 | 2022-11-30 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | 主引用文献 | Molecular basis for selective activation of DREADD-based chemogenetics. Nature, 612, 2022
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8E0G
| Re-refined model of active mu-opioid receptor (PDB 5c1m) as an adduct with BU72 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R,3S,3aR,5aR,6R,11bR,11cS)-3a-methoxy-3,14-dimethyl-2-phenyl-2,3,3a,6,7,11c-hexahydro-1H-6,11b-(epiminoethano)-3,5a-methanonaphtho[2,1-g]indol-10-ol, CHOLESTEROL, ... | 著者 | Munro, T.A. | 登録日 | 2022-08-09 | 公開日 | 2023-10-18 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Reanalysis of a mu opioid receptor crystal structure reveals a covalent adduct with BU72. Bmc Biol., 21, 2023
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8DZS
| GR89,696 bound Kappa Opioid Receptor in complex with Gz | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(z) subunit alpha, ... | 著者 | Fay, J.F, Che, T. | 登録日 | 2022-08-08 | 公開日 | 2023-05-03 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
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8DZR
| GR89,696 bound Kappa Opioid Receptor in complex with gustducin | 分子名称: | G alpha gustducin protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Fay, J.F, Che, T. | 登録日 | 2022-08-08 | 公開日 | 2023-05-03 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | 主引用文献 | Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
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8DZQ
| momSalB bound Kappa Opioid Receptor in complex with GoA | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... | 著者 | Fay, J.F, Che, T. | 登録日 | 2022-08-08 | 公開日 | 2023-05-03 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | 主引用文献 | Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
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8DZP
| momSalB bound Kappa Opioid Receptor in complex with Gi1 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Fay, J.F, Che, T. | 登録日 | 2022-08-08 | 公開日 | 2023-05-03 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
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8DWH
| CryoEM structure of Gq-coupled MRGPRX1 with ligand Compound-16 | 分子名称: | Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, Y, Cao, C, Fay, J.F, Roth, B.L. | 登録日 | 2022-08-01 | 公開日 | 2022-11-02 | 最終更新日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Ligand recognition and allosteric modulation of the human MRGPRX1 receptor. Nat.Chem.Biol., 19, 2023
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8DWG
| CryoEM structure of Gq-coupled MRGPRX1 with peptide ligand BAM8-22 and positive allosteric modulator ML382 | 分子名称: | 2-[(cyclopropanesulfonyl)amino]-N-(2-ethoxyphenyl)benzamide, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, Y, Cao, C, Fay, J.F, Roth, B.L. | 登録日 | 2022-08-01 | 公開日 | 2022-11-02 | 最終更新日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Ligand recognition and allosteric modulation of the human MRGPRX1 receptor. Nat.Chem.Biol., 19, 2023
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