8E9X

CryoEM structure of miniGo-coupled hM4Di in complex with DCZ

Summary for 8E9X

• Entry DOI: 10.2210/pdb8e9x/pdb
• EMDB information: 27967
• Descriptor: Muscarinic acetylcholine receptor M4, miniGo, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: gpcr, dcz, active state, membrane protein, hm4di, dreadd
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 136504.05

Authors

Zhang, S.,Fay, J.F.,Roth, B.L. (deposition date: 2022-08-27, release date: 2022-11-30, Last modification date: 2022-12-21)

• Primary citation: Zhang, S.,Gumpper, R.H.,Huang, X.P.,Liu, Y.,Krumm, B.E.,Cao, C.,Fay, J.F.,Roth, B.L.; Molecular basis for selective activation of DREADD-based chemogenetics.; Nature, 612:354-362, 2022; PubMed: 36450989; DOI: 10.1038/s41586-022-05489-0

Experimental method

ELECTRON MICROSCOPY (2.7 Å)