8E9Y

CryoEM structure of miniGq-coupled hM3Dq in complex with CNO

Summary for 8E9Y

Entry DOI	10.2210/pdb8e9y/pdb
EMDB information	27968
Descriptor	Muscarinic acetylcholine receptor M3, miniGq, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
Functional Keywords	gpcr, cno, active state, membrane protein, hm3r, dreadd
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	165659.48
Authors	Zhang, S.,Fay, J.F.,Roth, B.L. (deposition date: 2022-08-27, release date: 2022-11-30, Last modification date: 2022-12-21)
Primary citation	Zhang, S.,Gumpper, R.H.,Huang, X.P.,Liu, Y.,Krumm, B.E.,Cao, C.,Fay, J.F.,Roth, B.L. Molecular basis for selective activation of DREADD-based chemogenetics. Nature, 612:354-362, 2022 Cited by PubMed: 36450989 DOI: 10.1038/s41586-022-05489-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.79 Å)

Structure validation