PDB: 8861 件ウェブページステータス検索Chemie searchBIRD

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4CSR	High resolution crystal structure of the histone fold dimer (NF-YB)-(NF-YC) 分子名称: GLYCEROL, NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA, NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA 著者 Gnesutta, N, Cocolo, S, Mantovani, R, Bolognesi, M, Nardini, M. 登録日 2014-03-09 公開日 2015-03-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 High Resolution Crystal Structure of the Histone Fold Dimer (NF-Yb)-(NF-Yc) To be Published
9BAQ	CryoEM structure of DIM2-HP1-H3K9me3-DNA complex 分子名称: DNA (5'-D(*AP*CP*TP*AP*CP*T)-R(P*(PYO))-D(P*CP*TP*CP*CP*TP*CP*CP*TP*AP*CP*T)-3'), DNA (5'-D(*AP*GP*TP*AP*GP*GP*AP*GP*GP*AP*GP*GP*AP*GP*TP*AP*GP*T)-3'), DNA (cytosine-5-)-methyltransferase, ... 著者 Song, J, Shao, Z. 登録日 2024-04-04 公開日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.79 Å) 主引用文献 CryoEM structure of DIM2-HP1-H3K9me3-DNA complex To Be Published
7QQL	The PDZ domain of SNTG2 complexed with the phosphorylated PDZ-binding motif of RSK1 分子名称: CALCIUM ION, GLYCEROL, Gamma-2-syntrophin,Annexin A2, ... 著者 Cousido-Siah, A, Trave, G, Gogl, G. 登録日 2022-01-10 公開日 2022-04-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 A scalable strategy to solve structures of PDZ domains and their complexes. Acta Crystallogr D Struct Biol, 78, 2022
7TAD	CryoEM structure of the (NPR1)2-(TGA3)2 complex 分子名称: PALMITIC ACID, Regulatory protein NPR1, Transcription factor TGA3, ... 著者 Wu, Q, Zhou, Y, Bartesaghi, A, Dong, X, Zhou, P. 登録日 2021-12-20 公開日 2022-03-16 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis of NPR1 in activating plant immunity. Nature, 605, 2022
4CO8	Structure of the DNA binding ETS domain of human ETV4 分子名称: 1,2-ETHANEDIOL, ETS TRANSLOCATION VARIANT 4 著者 Newman, J.A, Cooper, C.D.O, Shrestha, L, Burgess-Brown, N, Kopec, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. 登録日 2014-01-27 公開日 2014-02-05 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation. J.Biol.Chem., 290, 2015
7TAC	Cryo-EM structure of the (TGA3)2-(NPR1)2-(TGA3)2 complex 分子名称: PALMITIC ACID, Regulatory protein NPR1, Transcription factor TGA3, ... 著者 Wu, Q, Zhou, Y, Bartesaghi, A, Dong, X, Zhou, P. 登録日 2021-12-20 公開日 2022-03-16 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis of NPR1 in activating plant immunity. Nature, 605, 2022
4CZZ	Histone demethylase LSD1(KDM1A)-CoREST3 Complex 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 3 著者 Barrios, A.P, Gomez, A.V, Saez, J.E, Ciossani, G, Toffolo, E, Battaglioli, E, Mattevi, A, Andres, M.E. 登録日 2014-04-23 公開日 2014-06-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Differential Properties of Transcriptional Complexes Formed by the Corest Family. Mol.Cell.Biol., 34, 2014
4D1X	CDK2 in complex with Luciferin 分子名称: (4S)-2-(6-hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid, CYCLIN-DEPENDENT KINASE 2 著者 Rothweiler, U, Engh, R.A. 登録日 2014-05-05 公開日 2015-03-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Luciferin and Derivatives as a Dyrk Selective Scaffold for the Design of Protein Kinase Inhibitors. Eur.J.Med.Chem., 94, 2015
8IHN	Cryo-EM structure of the Rpd3S core complex 分子名称: CALCIUM ION, Chromatin modification-related protein EAF3, Histone H3, ... 著者 Zhang, Y, Gang, C. 登録日 2023-02-23 公開日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.37 Å) 主引用文献 Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme. Cell Res., 33, 2023
4DHS	Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening 分子名称: (2-{2-[(3,5-dichlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 PROTEIN SIGMA, CHLORIDE ION, ... 著者 Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. 登録日 2012-01-30 公開日 2013-07-31 最終更新日 2013-09-04 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
3O4M	Crystal structure of porcine pancreatic phospholipase A2 in complex with 1,2-dihydroxybenzene 分子名称: CALCIUM ION, CATECHOL, Phospholipase A2, ... 著者 Dileep, K.V, Tintu, I, Karthe, P, Mandal, P.K, Haridas, M, Sadasivan, C. 登録日 2010-07-27 公開日 2010-08-25 最終更新日 2011-11-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Binding to PLA(2) may contribute to the anti-inflammatory activity of catechol Chem.Biol.Drug Des., 2011
7KSO	Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2 分子名称: Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... 著者 Grau, D.J, Armache, K.J. 登録日 2020-11-23 公開日 2021-02-03 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. Nat Commun, 12, 2021
6GEJ	Chromatin remodeller-nucleosome complex at 3.6 A resolution. 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin-like protein ARP6, BERYLLIUM TRIFLUORIDE ION, ... 著者 Willhoft, O, Chua, E.Y.D, Wilkinson, M, Wigley, D.B. 登録日 2018-04-26 公開日 2018-10-17 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structure and dynamics of the yeast SWR1-nucleosome complex. Science, 362, 2018
6GEN	Chromatin remodeller-nucleosome complex at 4.5 A resolution. 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin-like protein ARP6, BERYLLIUM TRIFLUORIDE ION, ... 著者 Willhoft, O, Chua, E.Y.D, Wilkinson, M, Wigley, D.B. 登録日 2018-04-27 公開日 2018-10-17 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structure and dynamics of the yeast SWR1-nucleosome complex. Science, 362, 2018
4W9H	pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 7) 分子名称: N-acetyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... 著者 Gadd, M.S, Soares, P, Galdeano, C, van Molle, I, Ciulli, A. 登録日 2014-08-27 公開日 2014-09-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
1JSU	P27(KIP1)/CYCLIN A/CDK2 COMPLEX 分子名称: CYCLIN A, CYCLIN-DEPENDENT KINASE-2, P27, ... 著者 Russo, A.A, Jeffrey, P.D, Pavletich, N.P. 登録日 1996-07-03 公開日 1997-07-29 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature, 382, 1996
4W9E	pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(thiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 4) 分子名称: (4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-[4-(1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... 著者 Gadd, M.S, Soares, P, Galdeano, C, van Molle, I, Ciulli, A. 登録日 2014-08-27 公開日 2014-09-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
1KBH	Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR 分子名称: CREB-BINDING PROTEIN, nuclear receptor coactivator 著者 Demarest, S.J, Martinez-Yamout, M, Chung, J, Chen, H, Xu, W, Dyson, H.J, Evans, R.M, Wright, P.E. 登録日 2001-11-06 公開日 2002-02-06 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature, 415, 2002
1K8K	Crystal Structure of Arp2/3 Complex 分子名称: ACTIN-LIKE PROTEIN 2, ACTIN-LIKE PROTEIN 3, ARP2/3 COMPLEX 16 KDA SUBUNIT, ... 著者 Robinson, R.C, Turbedsky, K, Kaiser, D.A, Higgs, H.N, Marchand, J.-B, Choe, S, Pollard, T.D. 登録日 2001-10-24 公開日 2001-12-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of Arp2/3 Complex Science, 294, 2001
4W9F	pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 5) 分子名称: (4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... 著者 van Molle, I, Hewitt, S, Galdeano, C, Gadd, M.S, Ciulli, A. 登録日 2014-08-27 公開日 2014-09-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
7ZVX	Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 2.4 A resolution 分子名称: 1,2-ETHANEDIOL, 2'-methoxyethyl DNA gapmer antisense oligonucleotide, Annexin A2, ... 著者 Hyjek-Skladanowska, M, Anderson, B, Mykhaylyk, V, Orr, C, Wagner, A, Skowronek, K, Seth, P, Nowotny, M. 登録日 2022-05-17 公開日 2022-09-14 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding. Nucleic Acids Res., 51, 2023
7ZVN	Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 1.87 A resolution 分子名称: 2'-methoxyethyl DNA gapmer antisense oligonucleotide, Annexin A2, CALCIUM ION, ... 著者 Hyjek-Skladanowska, M, Anderson, B, Mykhaylyk, V, Orr, C, Wagner, A, Skowronek, K, Seth, P, Nowotny, M. 登録日 2022-05-16 公開日 2022-09-14 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding. Nucleic Acids Res., 51, 2023
8TOF	Rpd3S bound to an H3K36Cme3 modified nucleosome 分子名称: Chromatin modification-related protein EAF3, DNA (176-MER), Histone H2A, ... 著者 Markert, J.W, Vos, S.M, Farnung, L. 登録日 2023-08-03 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structure of the complete Saccharomyces cerevisiae Rpd3S-nucleosome complex. Nat Commun, 14, 2023
4W9J	pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-((S)-2-acetamido-4-methylpentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 13) 分子名称: N-acetyl-L-leucyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... 著者 Gadd, M.S, Galdeano, C, van Molle, I, Ciulli, A. 登録日 2014-08-27 公開日 2014-09-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
4W9L	pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-((S)-2-acetamido-3,3-dimethylbutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 15) 分子名称: N-acetyl-3-methyl-L-valyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... 著者 Gadd, M.S, Galdeano, C, van Molle, I, Ciulli, A. 登録日 2014-08-27 公開日 2014-09-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014

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