7ZVN

Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 1.87 A resolution

Summary for 7ZVN

Entry DOI	10.2210/pdb7zvn/pdb
Descriptor	Annexin A2, 2'-methoxyethyl DNA gapmer antisense oligonucleotide, GLYCEROL, ... (6 entities in total)
Functional Keywords	nucleic acid binding, aso, antisense oligonucleotide, phosphorothioate, lipid binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	46780.63
Authors	Hyjek-Skladanowska, M.,Anderson, B.,Mykhaylyk, V.,Orr, C.,Wagner, A.,Skowronek, K.,Seth, P.,Nowotny, M. (deposition date: 2022-05-16, release date: 2022-09-14, Last modification date: 2024-02-07)
Primary citation	Hyjek-Skladanowska, M.,Anderson, B.A.,Mykhaylyk, V.,Orr, C.,Wagner, A.,Poznanski, J.T.,Skowronek, K.,Seth, P.,Nowotny, M. Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding. Nucleic Acids Res., 51:1409-1423, 2023 Cited by PubMed: 36124719 DOI: 10.1093/nar/gkac774 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation