7ZVN
Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 1.87 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Annexin A2 | polymer | 307 | 35150.1 | 1 | UniProt (P07355) Pfam (PF00191) | Homo sapiens (human) | Annexin II,Annexin-2,Calpactin I heavy chain,Calpactin-1 heavy chain,Chromobindin-8,Lipocortin II,Placental anticoagulant protein IV,PAP-IV,Protein I,p36 |
| 2 | B, C (C, D) | 2'-methoxyethyl DNA gapmer antisense oligonucleotide | polymer | 15 | 5294.5 | 2 | synthetic construct | ||
| 3 | D, E, F, G, H... (A) | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) PubChem (753) | |||
| 4 | L, M, N, O, P... (A) | CALCIUM ION | non-polymer | 40.1 | 7 | Chemie (CA) PubChem (271) | |||
| 5 | S (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 6 | T, U, V (A, C, D) | water | water | 18.0 | 352 | Chemie (HOH) |
Sequence modifications
A: 34 - 339 (UniProt: P07355)
| PDB | External Database | Details |
|---|---|---|
| Ser 33 | - | expression tag |
| Ala 293 | Val 293 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 45739.0 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1041.6 | |
| All* | Total formula weight | 46780.6 |
