7ZVX

Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 2.4 A resolution

Summary for 7ZVX

• Entry DOI: 10.2210/pdb7zvx/pdb
• Related: 7ZVN
• Descriptor: Annexin A2, 2'-methoxyethyl DNA gapmer antisense oligonucleotide, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: nucleic acid binding, aso, antisense oligonucleotide, phosphorothioate, lipid binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 91744.63

Authors

Hyjek-Skladanowska, M.,Anderson, B.,Mykhaylyk, V.,Orr, C.,Wagner, A.,Skowronek, K.,Seth, P.,Nowotny, M. (deposition date: 2022-05-17, release date: 2022-09-14, Last modification date: 2024-02-07)

• Primary citation: Hyjek-Skladanowska, M.,Anderson, B.A.,Mykhaylyk, V.,Orr, C.,Wagner, A.,Poznanski, J.T.,Skowronek, K.,Seth, P.,Nowotny, M.; Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding.; Nucleic Acids Res., 51:1409-1423, 2023; PubMed: 36124719; DOI: 10.1093/nar/gkac774

Experimental method

X-RAY DIFFRACTION (2.4 Å)