7ZVX

Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 2.4 A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Annexin A2	polymer	307	35150.1	2	UniProt (P07355) Pfam (PF00191) In PDB	Homo sapiens (human)	Annexin II,Annexin-2,Calpactin I heavy chain,Calpactin-1 heavy chain,Chromobindin-8,Lipocortin II,Placental anticoagulant protein IV,PAP-IV,Protein I,p36
2	C, D	2'-methoxyethyl DNA gapmer antisense oligonucleotide	polymer	30	10098.4	2		synthetic construct
3	A, B	CALCIUM ION	non-polymer		40.1	11	Chemie (CA)
4	B, A	1,2-ETHANEDIOL	non-polymer		62.1	13	Chemie (EDO)
5		water	water		18.0	241	Chemie (HOH)

Sequence modifications

A, B: 34 - 339 (UniProt: P07355)

PDB	External Database	Details
Ser 33	-	expression tag
Ala 293	Val 293	variant

C, D: 86 - 100 (PDB: 7ZVX)
C, D: 101 - 115 (PDB: 7ZVX)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	90496.9
Non-Polymers*	Number of molecules	24
	Total formula weight	1247.7
All*	Total formula weight	91744.6

*Water molecules are not included.