7UCV
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7UCZ
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7UD1
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7XA3
| Cryo-EM structure of the CCL2 bound CCR2-Gi complex | 分子名称: | C-C motif chemokine 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H. | 登録日 | 2022-03-17 | 公開日 | 2022-08-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3. Cell Discov, 8, 2022
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7UCX
| LRP8 11H1 Fab complexed to a cyclized CR1 peptide | 分子名称: | 11H1 Fab Heavy chain, 11H1 Fab Light chain, Cyclized CR1 peptide, ... | 著者 | Argiriadi, M.A, Deng, K, Egan, D, Gao, L, Gizatullin, F, Harlan, J, Karaoglu, D, Qiu, W, Goodearl, A. | 登録日 | 2022-03-17 | 公開日 | 2023-01-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | The use of cyclic peptide antigens to generate LRP8 specific antibodies Front Drug Discov (Lausanne), 2, 2023
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7Z7T
| Complex I from E. coli, LMNG-purified, under Turnover at pH 6, Open state | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, CALCIUM ION, ... | 著者 | Kravchuk, V, Kampjut, D, Sazanov, L. | 登録日 | 2022-03-16 | 公開日 | 2022-09-21 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
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7Z83
| Complex I from E. coli, DDM/LMNG-purified, under Turnover at pH 8, Open state | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, CALCIUM ION, ... | 著者 | Kravchuk, V, Kampjut, D, Sazanov, L. | 登録日 | 2022-03-16 | 公開日 | 2022-09-21 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
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7Z8A
| Sam68 | 分子名称: | 1,2-ETHANEDIOL, KHDR1 protein, LITHIUM ION, ... | 著者 | Nadal, M, Fuentes-Prior, P. | 登録日 | 2022-03-16 | 公開日 | 2023-02-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Structure and function analysis of Sam68 and hnRNP A1 synergy in the exclusion of exon 7 from SMN2 transcripts. Protein Sci., 32, 2023
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7Z89
| Sam68 | 分子名称: | 1,2-ETHANEDIOL, IODIDE ION, Isoform 2 of KH domain-containing, ... | 著者 | Nadal, M, Fuentes-Prior, P. | 登録日 | 2022-03-16 | 公開日 | 2023-02-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Structure and function analysis of Sam68 and hnRNP A1 synergy in the exclusion of exon 7 from SMN2 transcripts. Protein Sci., 32, 2023
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7UC7
| Stat5a Core in complex with Compound 17 | 分子名称: | GLYCEROL, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(1-benzofuran-5-yl)-N,N-dimethyl-beta-alaninamide, Signal transducer and activator of transcription 5A | 著者 | Meagher, J.L, Stuckey, J.A. | 登録日 | 2022-03-16 | 公開日 | 2023-02-15 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.102 Å) | 主引用文献 | Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia. J.Med.Chem., 66, 2023
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7UCN
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7Z84
| Complex I from E. coli, DDM/LMNG-purified, under Turnover at pH 8, Open-ready state | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, CALCIUM ION, ... | 著者 | Kravchuk, V, Kampjut, D, Sazanov, L. | 登録日 | 2022-03-16 | 公開日 | 2022-09-21 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | 主引用文献 | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
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7Z7S
| Complex I from E. coli, LMNG-purified, under Turnover at pH 6, Closed state | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione, ... | 著者 | Kravchuk, V, Kampjut, D, Sazanov, L. | 登録日 | 2022-03-16 | 公開日 | 2022-09-21 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
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7Z80
| Complex I from E. coli, DDM/LMNG-purified, under Turnover at pH 8, Closed state | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione, ... | 著者 | Kravchuk, V, Kampjut, D, Sazanov, L. | 登録日 | 2022-03-16 | 公開日 | 2022-09-21 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
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7Z7V
| Complex I from E. coli, LMNG-purified, under Turnover at pH 6, Open-ready state | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, CALCIUM ION, ... | 著者 | Kravchuk, V, Kampjut, D, Sazanov, L. | 登録日 | 2022-03-16 | 公開日 | 2022-09-21 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.29 Å) | 主引用文献 | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
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7Z7R
| Complex I from E. coli, LMNG-purified, Apo, Open-ready state | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CALCIUM ION, EICOSANE, ... | 著者 | Kravchuk, V, Kampjut, D, Sazanov, L. | 登録日 | 2022-03-16 | 公開日 | 2022-09-21 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
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7X9Y
| Cryo-EM structure of the apo CCR3-Gi complex | 分子名称: | C-C chemokine receptor type 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H. | 登録日 | 2022-03-16 | 公開日 | 2022-08-24 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3. Cell Discov, 8, 2022
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7UC6
| Stat5a Core in complex with Compound 12 | 分子名称: | N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(4-bromophenyl)-N,N-dimethyl-beta-alaninamide, Signal transducer and activator of transcription 5A | 著者 | Meagher, J.L, Stuckey, J.A. | 登録日 | 2022-03-16 | 公開日 | 2023-02-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (3.101 Å) | 主引用文献 | Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia. J.Med.Chem., 66, 2023
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7Z7D
| Tubulin-Todalam-Vinblastine-complex | 分子名称: | (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Roy, B, Prota, A.E, Cavalli, A, Steinmetz, M.O. | 登録日 | 2022-03-15 | 公開日 | 2022-04-27 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action. Angew.Chem.Int.Ed.Engl., 61, 2022
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7Z7I
| Structure of ADP-ribosylated F-actin | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, Actin, ... | 著者 | Belyy, A, Raunser, S. | 登録日 | 2022-03-15 | 公開日 | 2022-06-29 | 最終更新日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin. Nat Commun, 13, 2022
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7Z7H
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7UBP
| The crystal structure of the K36A/K137A double mutant of E. coli YGGS in complex with PLP | 分子名称: | PYRIDOXAL-5'-PHOSPHATE, Pyridoxal phosphate homeostasis protein, SULFATE ION | 著者 | Donkor, A.K, Ghatge, M.S, Musayev, F.N, Safo, M.K. | 登録日 | 2022-03-15 | 公開日 | 2022-03-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability. Protein Sci., 31, 2022
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7UBQ
| The crystal structure of the wild-type of E. coli YGGS in complex with PNP | 分子名称: | PYRIDOXINE-5'-PHOSPHATE, Pyridoxal phosphate homeostasis protein | 著者 | Donkor, A.K, Ghatge, M.S, Musayev, F.N, Safo, M.K. | 登録日 | 2022-03-15 | 公開日 | 2022-03-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability. Protein Sci., 31, 2022
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7UBT
| Stat5a Core in complex with Compound 18 | 分子名称: | GLYCEROL, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(1,3-benzothiazol-5-yl)-N,N-dimethyl-beta-alaninamide, Signal transducer and activator of transcription 5A | 著者 | Meagher, J.L, Stuckey, J.A. | 登録日 | 2022-03-15 | 公開日 | 2023-02-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.352 Å) | 主引用文献 | Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia. J.Med.Chem., 66, 2023
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7X9B
| Cryo-EM structure of neuropeptide Y Y2 receptor in complex with NPY and Gi | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Tang, T, Han, S, Zhao, Q, Wu, B. | 登録日 | 2022-03-15 | 公開日 | 2022-05-18 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors. Sci Adv, 8, 2022
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