6OE1
 
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9O93
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8GLS
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9O7S
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6OET
 | | Cryo-EM structure of mouse RAG1/2 STC complex | | 分子名称: | CALCIUM ION, DNA (30-MER), DNA (39-MER), ... | | 著者 | Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. | | 登録日 | 2019-03-27 | | 公開日 | 2020-01-22 | | 最終更新日 | 2025-05-21 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | How mouse RAG recombinase avoids DNA transposition.
Nat.Struct.Mol.Biol., 27, 2020
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6OUB
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6OTP
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8QEL
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6OUI
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6WNG
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7P0E
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6OX7
 | | The complex of 1918 NS1-ED and the iSH2 domain of the human p85beta subunit of PI3K | | 分子名称: | Non-structural protein 1, Phosphatidylinositol 3-kinase regulatory subunit beta | | 著者 | Shen, Q, Zhao, B, Li, P, Cho, J.H. | | 登録日 | 2019-05-13 | | 公開日 | 2020-04-22 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Molecular recognition of a host protein by NS1 of pandemic and seasonal influenza A viruses.
Proc.Natl.Acad.Sci.USA, 117, 2020
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8BD3
 | | Cryo-EM structure of the Photosystem II - LHCII supercomplex from Chlorella ohadi | | 分子名称: | (1R,3R)-6-{(3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1S,4R,6R)-4-HYDROXY-2,2,6-TRIMETHYL-7-OXABICYCLO[4.1.0]HEPT-1-YL]-3,7,12,16-TETRAMETHYLOCTADECA-1,3,5,7,9,11,13,15,17-NONAENYLIDENE}-1,5,5-TRIMETHYLCYCLOHEXANE-1,3-DIOL, (3R)-beta,beta-caroten-3-ol, (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, ... | | 著者 | Fadeeva, M, Klaiman, D, Caspy, I, Nelson, N. | | 登録日 | 2022-10-18 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-08-23 | | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | | 主引用文献 | Structure of Chlorella ohadii Photosystem II Reveals Protective Mechanisms against Environmental Stress.
Cells, 12, 2023
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7OY1
 | | DnrK mutant RTCR | | 分子名称: | Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB, S-ADENOSYL-L-HOMOCYSTEINE, methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate | | 著者 | Dinis, P, MetsaKetela, M. | | 登録日 | 2021-06-23 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Evolution-inspired engineering of anthracycline methyltransferases.
Pnas Nexus, 2, 2023
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6Z2C
 | | Engineered lipocalin C3A5 in complex with a transition state analog | | 分子名称: | 1,7,8,9,10,10-hexachloro-4-carboxypentyl-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione, Neutrophil gelatinase-associated lipocalin | | 著者 | Skerra, A, Eichinger, A. | | 登録日 | 2020-05-15 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of an engineered lipocalin that catalyzes a Diels-Alder reaction
To be published
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6OP0
 | | Asymmetric hTNF-alpha | | 分子名称: | (R)-{1-[(2,5-dimethylphenyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl}(pyridin-4-yl)methanol, Tumor necrosis factor | | 著者 | Arakaki, T.L, Edwards, T.E, Fairman, J.W, Davies, D.R, Foley, A, Ceska, T. | | 登録日 | 2019-04-23 | | 公開日 | 2019-12-25 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.
Nat Commun, 10, 2019
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8GZC
 | | Crystal structure of EP300 HAT domain in complex with compound 10 | | 分子名称: | (2~{R},4~{R})-4-fluoranyl-1-[1-(4-methoxyphenyl)cyclohexyl]carbonyl-~{N}-(1~{H}-pyrazolo[4,3-b]pyridin-5-yl)pyrrolidine-2-carboxamide, Histone acetyltransferase p300, ZINC ION | | 著者 | Takahashi, M, Hanzawa, H. | | 登録日 | 2022-09-26 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Discovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor.
J.Med.Chem., 66, 2023
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7N19
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6XGZ
 | | Crystal structure of E. coli MlaFB ABC transport subunits in the monomeric state | | 分子名称: | 1,2-ETHANEDIOL, ABC transporter maintaining OM lipid asymmetry, cytoplasmic STAS component, ... | | 著者 | Chang, Y, Bhabha, G, Ekiert, D.C. | | 登録日 | 2020-06-18 | | 公開日 | 2020-07-15 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation.
Elife, 9, 2020
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6XI0
 | | R. capsulatus cyt bc1 (CIII2) at 3.3A | | 分子名称: | Cytochrome b, Cytochrome c1, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Steimle, S, Van Eeuwen, T, Ozturk, Y, Kim, H.J, Braitbard, M, Selamoglu, N, Garcia, B.A, Schneidman-Duhovny, D, Murakami, K, Daldal, F. | | 登録日 | 2020-06-19 | | 公開日 | 2020-12-30 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structures of engineered active bc 1 -cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes.
Nat Commun, 12, 2021
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8QNG
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7P73
 | | The PDZ domain of SYNJ2BP complexed with the PDZ-binding motif of HTLV1-TAX1 | | 分子名称: | CALCIUM ION, GLYCEROL, Protein Tax-1, ... | | 著者 | Gogl, G, Cousido-Siah, A, Trave, G. | | 登録日 | 2021-07-19 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Quantitative fragmentomics allow affinity mapping of interactomes.
Nat Commun, 13, 2022
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6ZEQ
 | | Aspergillus oryzae Leucine Aminopeptidase A mature enzyme | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Watson, K.A, Baltulionis, G. | | 登録日 | 2020-06-16 | | 公開日 | 2021-06-16 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | The role of propeptide-mediated autoinhibition and intermolecular chaperone in the maturation of cognate catalytic domain in leucine aminopeptidase.
J.Struct.Biol., 213, 2021
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7P74
 | | The PDZ domain of SYNJ2BP complexed with the phosphorylated PDZ-binding motif of RSK1 | | 分子名称: | CALCIUM ION, GLYCEROL, Ribosomal protein S6 kinase alpha-1, ... | | 著者 | Gogl, G, Cousido-Siah, A, Trave, G. | | 登録日 | 2021-07-19 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Quantitative fragmentomics allow affinity mapping of interactomes.
Nat Commun, 13, 2022
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9OJO
 | | Crystal structure of TNF alpha in complex with compound 1 | | 分子名称: | 2-{5-[(1S,10S)-1-phenyl-1,2,3,4-tetrahydropyrido[1,2-a][1,3]benzimidazol-8-yl]pyrimidin-2-yl}propan-2-ol, Tumor necrosis factor | | 著者 | Judge, R.A, Bian, Z, Longenecker, K.L. | | 登録日 | 2025-05-08 | | 公開日 | 2025-07-23 | | 最終更新日 | 2025-08-27 | | 実験手法 | X-RAY DIFFRACTION (1.358 Å) | | 主引用文献 | Discovery of Orally Efficacious Bridged Piperazines as smTNF Modulators.
J.Med.Chem., 68, 2025
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