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3T8I
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Structural analysis of thermostable S. solfataricus purine-specific nucleoside hydrolase
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
著者Minici, C, Cacciapuoti, G, De Leo, E, Porcelli, M, Degano, M.
登録日2011-08-01
公開日2012-05-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献New Determinants in the Catalytic Mechanism of Nucleoside Hydrolases from the Structures of Two Isozymes from Sulfolobus solfataricus.
Biochemistry, 51, 2012
3FDT
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Crystal structure of the complex of human chromobox homolog 5 (CBX5) with H3K9(me)3 peptide
分子名称: Chromobox protein homolog 5, H3K9(me)3 peptide
著者Amaya, M.F, Ravichandran, M, Loppnau, P, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Min, J, Ouyang, H, Structural Genomics Consortium (SGC)
登録日2008-11-26
公開日2009-01-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Recognition and specificity determinants of the human cbx chromodomains.
J.Biol.Chem., 286, 2011
2WD8
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PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH NADP AND DDD00071204
分子名称: 1-(3,4-DICHLOROBENZYL)-7-PHENYL-1H-BENZIMIDAZOL-2-AMINE, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Robinson, D.A, Wyatt, P.G, Spinks, D, Brenk, R.
登録日2009-03-20
公開日2009-06-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening.
J.Med.Chem., 52, 2009
3F5N
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Structure of native human neuroserpin
分子名称: Neuroserpin
著者Ricagno, S, Caccia, S, Sorrentino, G, Bolognesi, M.
登録日2008-11-04
公開日2009-05-26
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Human neuroserpin: structure and time-dependent inhibition
J.Mol.Biol., 388, 2009
3FEE
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BU of 3fee by Molmil
The high resolution structure of human glutamate carboxypeptidase III (GCPIII/NAALADase II) in complex with quisqualic acid
分子名称: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Lubkowski, J, Barinka, C, Hlouchova, K.
登録日2008-11-28
公開日2009-08-25
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III
Febs J., 276, 2009
3FHC
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Crystal structure of human Dbp5 in complex with Nup214
分子名称: ATP-dependent RNA helicase DDX19B, Nuclear pore complex protein Nup214
著者von Moeller, H, Conti, E.
登録日2008-12-09
公開日2009-02-17
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner
Nat.Struct.Mol.Biol., 16, 2009
3FJC
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Crystal structure of L44W mutant of Human acidic fibroblast growth factor
分子名称: FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION
著者Blaber, M, Lee, J.
登録日2008-12-14
公開日2009-10-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1.
J.Mol.Biol., 393, 2009
2WBP
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Crystal structure of VioC in complex with Fe(II), (2S,3S)- hydroxyarginine, and succinate
分子名称: (2S,3S)-3-HYDROXYARGININE, ARGININE, FE (II) ION, ...
著者Helmetag, V, Samel, S.A, Thomas, M.G, Marahiel, M.A, Essen, L.-O.
登録日2009-03-02
公開日2009-06-23
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.16 Å)
主引用文献Structural Basis for the Erythro-Stereospecificity of the L-Arginine Oxygenase Vioc in Viomycin Biosynthesis.
FEBS J., 276, 2009
3FJZ
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E. coli EPSP synthase (T97I) liganded with S3P and glyphosate
分子名称: 3-phosphoshikimate 1-carboxyvinyltransferase, FORMIC ACID, N-(phosphonomethyl)glycine, ...
著者Schonbrunn, E.
登録日2008-12-15
公開日2009-02-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Basis of Glyphosate Resistance Resulting from the Double Mutation Thr97 -> Ile and Pro101 -> Ser in 5-Enolpyruvylshikimate-3-phosphate Synthase from Escherichia coli.
J.Biol.Chem., 284, 2009
2VPA
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BU of 2vpa by Molmil
High resolution crystal structure of the antibiotic resistance protein NimA from Deinococcus radiodurans
分子名称: ACETATE ION, NIMA-RELATED PROTEIN, PYRUVIC ACID
著者Leiros, H.-K.S, Tedesco, C, McSweeney, S.M.
登録日2008-02-27
公開日2008-08-19
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献High-Resolution Structure of the Antibiotic Resistance Protein Nima from Deinococcus Radiodurans.
Acta Crystallogr.,Sect.F, 64, 2008
3TGV
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Crystal structure of HutZ,the heme storsge protein from Vibrio cholerae
分子名称: BENZOIC ACID, Heme-binding protein HutZ
著者Liu, X, Gong, J, Wang, Z, Du, Q, Wei, T, Zhu, D, Huang, Y, Xu, S, Gu, L.
登録日2011-08-17
公開日2012-08-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.999 Å)
主引用文献Crystal structure of HutZ,the heme storsge protein from Vibrio cholerae
To be Published
3TH6
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Crystal structure of Triosephosphate isomerase from Rhipicephalus (Boophilus) microplus.
分子名称: Triosephosphate isomerase
著者Arreola, R, Rodriguez-Romero, A, Moraes, J, Gomez-Puyou, A, Perez-Montfort, R, Logullo, C.
登録日2011-08-18
公開日2011-08-31
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural and biochemical characterization of a recombinant triosephosphate isomerase from Rhipicephalus (Boophilus) microplus.
Insect Biochem.Mol.Biol., 41, 2011
3T3O
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Molecular basis for the recognition and cleavage of RNA (CUGG) by the bifunctional 5'-3' exo/endoribonuclease RNase J
分子名称: GLYCEROL, Metal dependent hydrolase, O2'methyl-RNA, ...
著者Dorleans, A, Li de la Sierra-Gallay, I, Piton, J, Zig, L, Gilet, L, Putzer, H, Condon, C.
登録日2011-07-25
公開日2011-10-19
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular Basis for the Recognition and Cleavage of RNA by the Bifunctional 5'-3' Exo/Endoribonuclease RNase J.
Structure, 19, 2011
3T4G
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BU of 3t4g by Molmil
AIIGLMV segment from Alzheimer's Amyloid-Beta displayed on 54-membered macrocycle scaffold
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclic pseudo-peptide (ORN)AIIGLMV(ORN)KF(HAO)(4BF)K
著者Zhao, M, Liu, C, Cheng, P.N, Eisenberg, D, Nowick, J.S.
登録日2011-07-26
公開日2012-10-31
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Amyloid beta-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity.
Nat Chem, 4, 2012
3T4K
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BU of 3t4k by Molmil
Arabidopsis histidine kinase 4 sensor domain in complex with N-benzyladenine
分子名称: Histidine kinase 4, MALONATE ION, N-BENZYL-9H-PURIN-6-AMINE
著者Hothorn, M.
登録日2011-07-26
公開日2011-10-05
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Structural basis for cytokinin recognition by Arabidopsis thaliana histidine kinase 4.
Nat.Chem.Biol., 7, 2011
3FED
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BU of 3fed by Molmil
The high resolution structure of human glutamate carboxypeptidase III (GCPIII/NAALADase II) in complex with a transition state analog of Glu-Glu
分子名称: (2S)-2-{[(S)-[(3S)-3-amino-3-carboxypropyl](hydroxy)phosphoryl]methyl}pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Lubkowski, J, Barinka, C, Hlouchova, K.
登録日2008-11-28
公開日2009-08-25
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III
Febs J., 276, 2009
2WQX
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InlB321_4R: S199R, D200R, G206R, A227R, C242A mutant of the Listeria monocytogenes InlB internalin domain
分子名称: INTERNALIN B
著者Niemann, H.H, Ferraris, D.M, Heinz, D.W.
登録日2009-08-27
公開日2009-11-10
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Ligand-Mediated Dimerization of the met Receptor Tyrosine Kinase by the Bacterial Invasion Protein Inlb.
J.Mol.Biol., 395, 2010
3FXR
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Crystal structure of TsaR in complex with sulfate
分子名称: ASCORBIC ACID, GLYCEROL, LysR type regulator of tsaMBCD, ...
著者Monferrer, D, Tralau, T, Kertesz, M.A, Kikhney, A, Svergun, D, Uson, I.
登録日2009-01-21
公開日2010-01-26
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural studies on the full-length LysR-type regulator TsaR from Comamonas testosteroni T-2 reveal a novel open conformation of the tetrameric LTTR fold
Mol.Microbiol., 75, 2010
2WV0
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Crystal structure of the GntR-HutC family member YvoA from Bacillus subtilis
分子名称: HTH-TYPE TRANSCRIPTIONAL REPRESSOR YVOA, SULFATE ION
著者Resch, M, Schiltz, E, Titgemeyer, F, Muller, Y.A.
登録日2009-10-12
公開日2010-01-12
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Insight Into the Induction Mechanism of the Gntr/Hutc Bacterial Transcription Regulator Yvoa
Nucleic Acids Res., 38, 2010
2X04
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BU of 2x04 by Molmil
Crystal structure of the PABC-TNRC6C complex
分子名称: POLYADENYLATE-BINDING PROTEIN 1, SULFATE ION, TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN
著者Jinek, M, Fabian, M.R, Coyle, S.M, Sonenberg, N, Doudna, J.A.
登録日2009-12-04
公開日2010-01-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Structural Insights Into the Human Gw182-Pabc Interaction in Microrna-Mediated Deadenylation
Nat.Struct.Mol.Biol., 17, 2010
2WNL
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CRYSTAL STRUCTURE OF APLYSIA ACHBP IN COMPLEX WITH ANABASEINE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4,5,6-tetrahydro-2,3'-bipyridine, 5-amino-1-pyridin-3-ylpentan-1-one, ...
著者Sulzenbacher, G, Hibbs, R, Shi, J, Talley, T, Conrod, S, Kem, W, Taylor, P, Marchot, P, Bourne, Y.
登録日2009-07-09
公開日2009-09-01
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor.
EMBO J., 28, 2009
2X6X
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Tailspike protein mutant D339N of E.coli bacteriophage HK620 in complex with hexasaccharide
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, TAILSPIKE PROTEIN HK620, alpha-L-rhamnopyranose-(1-6)-alpha-D-glucopyranose-(1-4)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)]alpha-D-galactopyranose
著者Lorenzen, N.K, Mueller, J.J, Heinemann, U, Seckler, R, Barbirz, S.
登録日2010-02-22
公開日2011-03-02
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Single Amino Acid Exchange in Bacteriophage Hk620 Tailspike Protein Results in Thousand-Fold Increase of its Oligosaccharide Affinity.
Glycobiology, 23, 2013
3FU3
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Leukotriene A4 hydrolase in complex with fragment 4-(2-amino-1,3-thiazol-4-yl)phenol
分子名称: 4-(2-amino-1,3-thiazol-4-yl)phenol, ACETATE ION, IMIDAZOLE, ...
著者Davies, D.R.
登録日2009-01-13
公開日2009-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
J.Med.Chem., 52, 2009
3FUK
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Leukotriene A4 hydrolase in complex with 1-[2-(1H-indol-5-yloxy)ethyl]piperidine-4-carboxylic acid
分子名称: 1-[2-(1H-indol-5-yloxy)ethyl]piperidine-4-carboxylic acid, ACETATE ION, IMIDAZOLE, ...
著者Davies, D.R.
登録日2009-01-14
公開日2009-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
J.Med.Chem., 52, 2009
3FTZ
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Leukotriene A4 hydrolase in complex with fragment 2-(pyridin-3-ylmethoxy)aniline
分子名称: 2-(pyridin-3-ylmethoxy)aniline, ACETATE ION, IMIDAZOLE, ...
著者Davies, D.R.
登録日2009-01-13
公開日2010-01-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis.
J.Med.Chem., 53, 2010

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