PDB: 222415 件ウェブページステータス検索Chemie searchBIRD

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9F9M	Crystal structure of MUS81-EME1 bound by compound 21. 分子名称: 5-oxidanyl-4-oxidanylidene-1-(4-piperazin-1-ylphenyl)pyridine-3-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ... 著者 Collie, G.W. 登録日 2024-05-08 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.469 Å) 主引用文献 Fragment-Based Discovery of Novel MUS81 Inhibitors Acs Med.Chem.Lett., 2024
9B55	Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 1 分子名称: 4-aminobutanenitrile, E3 ubiquitin-protein ligase pub2, Ubiquitin, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
8XAV	Cryo-EM structure of an anti-phage defense complex 分子名称: ATP-binding protein, DUF4297 著者 Wang, Y, Deng, Z. 登録日 2023-12-05 公開日 2024-06-05 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (2.87 Å) 主引用文献 Molecular and structural basis of an ATPase-nuclease dual-enzyme anti-phage defense complex. Cell Res., 2024
9EUB	The FK1 domain of FKBP51 in complex with SAFit-analog 24e 分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, [1-(2-hydroxyethyl)pyrazol-4-yl]methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate 著者 Meyners, C, Buffa, V, Hausch, F. 登録日 2024-03-27 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 1,4-Pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile. Chemmedchem, 2024
9B5G	Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - cluster 2 map and model (Ub(A)/ATP/Mg) 分子名称: 4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, Large ribosomal subunit protein eL40B, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.67 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
8YKI	FGFR-1 in complex with ligand tasurgratinib 分子名称: CHLORIDE ION, Fibroblast growth factor receptor 1, Tasurgratinib 著者 Ikemori-Kawada, M, Watanabe Miyano, S. 登録日 2024-03-05 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Antitumor Activity of Tasurgratinib as an Orally Available FGFR1-3 Inhibitor in Cholangiocarcinoma Models With FGFR2-fusion. Anticancer Res., 44, 2024
8YXP	Structure of mumps virus L protein (state2) 分子名称: RNA-directed RNA polymerase L, ZINC ION 著者 Li, T.H, Shen, Q.T. 登録日 2024-04-02 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Structures of the mumps virus polymerase complex via cryo-electron microscopy. Nat Commun, 15, 2024
8ZEY	Anti-CRISPR type I subtype E3;AcrIE3 分子名称: AcrIE3 著者 Kim, D.Y, Park, H.H. 登録日 2024-05-07 公開日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.734 Å) 主引用文献 Novel structure of the anti-CRISPR protein AcrIE3 and its implication on the CRISPR-Cas inhibition. Biochem.Biophys.Res.Commun., 722, 2024
9FHP	CryoEM structure of wild-type Turnip Yellows Virus 分子名称: Minor capsid readthrough protein 著者 Trapani, S, Lai Kee Him, J, Hoh, F, Brault, V, Bron, P. 登録日 2024-05-28 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (4.08 Å) 主引用文献 CryoEM structure of wild-type Turnip Yellows Virus To Be Published
7QTV	Beryllium fluoride form of the Na+,K+-ATPase (E2-BeFx) 分子名称: 1-O-decanoyl-beta-D-tagatofuranosyl beta-D-allopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Fruergaard, M.U, Dach, I, Andersen, J.L, Ozol, M, Shahsavar, A, Quistgaard, E.M, Poulsen, H, Fedosova, N.U, Nissen, P. 登録日 2022-01-16 公開日 2022-11-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (4.05 Å) 主引用文献 The Na + ,K + -ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state. J.Biol.Chem., 298, 2022
8XH6	Structure of EBV LMP1 dimer 分子名称: Latent membrane protein 1 著者 Gao, P, Huang, J.F. 登録日 2023-12-17 公開日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.52 Å) 主引用文献 Assembly and activation of EBV latent membrane protein 1 To Be Published
9EVX	cryoEM structure of Photosystem II averaged across S2-S3 states at 1.71 Angstrom resolution 分子名称: 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... 著者 Hussein, R, Graca, A, Zouni, A, Messinger, J, Schroder, W.P. 登録日 2024-04-02 公開日 2024-06-12 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (1.71 Å) 主引用文献 Cryo-electron microscopy reveals hydrogen positions and water networks in photosystem II. Science, 384, 2024
8ZN1	Structure of erythrose-4-phosphate dehydrogenase from Acinetobacter baumannii at 3.00 A resolution 分子名称: Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION 著者 Viswanathan, V, Kumari, A, Singh, A, Kumar, A, Sharma, P, Chopra, S, Sharma, S, Raje, C.I, Singh, T.P. 登録日 2024-05-25 公開日 2024-06-05 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of erythrose-4-phosphate dehydrogenase from Acinetobacter baumannii at 3.00 A resolution To Be Published
8Y65	Cryo-EM structure of human urate transporter GLUT9 bound to substrate urate 分子名称: Solute carrier family 2, facilitated glucose transporter member 9, URIC ACID 著者 Pan, X.J, Shen, Z.L, Xu, L, Huang, G.X.Y. 登録日 2024-02-01 公開日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.51 Å) 主引用文献 Structural basis for urate recognition and apigenin inhibition of human GLUT9. Nat Commun, 15, 2024
8Y66	Cryo-EM structure of human urate transporter GLUT9 bound to inhibitor apigenin 分子名称: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, Solute carrier family 2, facilitated glucose transporter member 9 著者 Pan, X.J, Shen, Z.L, Xu, L, Huang, G.X.Y. 登録日 2024-02-01 公開日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.28 Å) 主引用文献 Structural basis for urate recognition and apigenin inhibition of human GLUT9. Nat Commun, 15, 2024
8ZN4	Crystal structure of Poly(ethylene glycol) stabilized erythrose-4-phosphate dehydrogenase from Acinetobacter baumannii at 2.30 A resolution 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, ... 著者 Viswanathan, V, Kumari, A, Singh, A, Kumar, A, Sharma, P, Chopra, S, Sharma, S, Raje, C.I, Singh, T.P. 登録日 2024-05-25 公開日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of Poly(ethylene glycol) stabilized erythrose-4-phosphate dehydrogenase from Acinetobacter baumannii at 2.30 A resolution To Be Published
9BB2	Backbone Modification in the GA Module of Protein PAB: beta3-residues at positions 20 and 24 分子名称: Peptostreptococcal albumin-binding protein 著者 Lin, Y, Horne, W.S. 登録日 2024-04-05 公開日 2024-06-05 実験手法 SOLUTION NMR 主引用文献 Backbone Modification in a Protein Hydrophobic Core. Chemistry, 2024
8Z9A	Cryo-EM structure of the insect olfactory receptor OR5-Orco heterocomplex from Acyrthosiphon pisum bound with geranyl acetate 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Odorant receptor, ApisOR5, ... 著者 Wang, Y.D, Qiu, L, Guan, Z.Y, Wang, Q, Wang, G.R, Yin, P. 登録日 2024-04-23 公開日 2024-06-19 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural basis for odorant recognition of the insect odorant receptor OR-Orco heterocomplex. Science, 384, 2024
8X8S	Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment 分子名称: Polyhedrin,Myc proto-oncogene protein 著者 Kojima, M, Ueno, T, Abe, S, Hirata, K. 登録日 2023-11-28 公開日 2024-06-05 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 High-throughput structure determination of an intrinsically disordered protein using cell-free protein crystallization. Proc.Natl.Acad.Sci.USA, 121, 2024
9B58	Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 4 分子名称: 4-aminobutanenitrile, E3 ubiquitin-protein ligase pub2, Ubiquitin, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
6D6Q	Human nuclear exosome-MTR4 RNA complex - overall reconstruction 分子名称: DNA/RNA (62-MER), Exosome RNA helicase MTR4, Exosome complex component CSL4, ... 著者 Weick, E.-M, Lima, C.D. 登録日 2018-04-22 公開日 2018-06-20 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.45 Å) 主引用文献 Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex. Cell, 173, 2018
9B5D	Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - Ub(T) class 1 map and model from consensus 分子名称: 4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, Large ribosomal subunit protein eL40B, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
7X09	Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with inhibitors L95 and Halofuginone 分子名称: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, BROMIDE ION, Bifunctional glutamate/proline--tRNA ligase, ... 著者 Manickam, Y, Babbar, P, Pillai, P, Sharma, A. 登録日 2022-02-21 公開日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of Homo sapiens Prolyl-tRNA synthetase (HsPRS) with double inhibitors (HF and L95) To Be Published
8ZNC	Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH, AKG in the steady stage of reaction 分子名称: 2-OXOGLUTARIC ACID, AMMONIUM ION, Glutamate dehydrogenase, ... 著者 Wakabayashi, T, Nakasako, M. 登録日 2024-05-26 公開日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.41 Å) 主引用文献 Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by crystal structure and cryoEM-sampling of metastable conformation in action To Be Published
9EU8	The FK1 domain of FKBP51 in complex with SAFit-analog 15h 分子名称: (4-methyl-1,3-thiazol-5-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 著者 Meyners, C, Buffa, V, Hausch, F. 登録日 2024-03-27 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 1,4-Pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile. Chemmedchem, 2024

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