7X09

Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with inhibitors L95 and Halofuginone

Summary for 7X09

• Entry DOI: 10.2210/pdb7x09/pdb
• Descriptor: Bifunctional glutamate/proline--tRNA ligase, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide, ... (9 entities in total)
• Functional Keywords: protein translation, inhibitor, prs, atp pocket, double drug, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 117344.59

Authors

Manickam, Y.,Babbar, P.,Pillai, P.,Sharma, A. (deposition date: 2022-02-21, release date: 2023-08-30)

• Primary citation: Manickam, Y.,Babbar, P.,Sharma, A.; Crystal structure of Homo sapiens Prolyl-tRNA synthetase (HsPRS) with double inhibitors (HF and L95); To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)