6LTJ
| Structure of nucleosome-bound human BAF complex | 分子名称: | AT-rich interactive domain-containing protein 1A, Actin, cytoplasmic 1, ... | 著者 | He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y. | 登録日 | 2020-01-22 | 公開日 | 2020-02-12 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of nucleosome-bound human BAF complex. Science, 367, 2020
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4DAU
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7SI5
| CRYSTAL STRUCTURE OF EED WITH MRTX-1919 | 分子名称: | (4R)-8-(1,3-dimethyl-1H-pyrazol-5-yl)-5-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}imidazo[1,2-c]pyrimidine-2-carbonitrile, 1,2-ETHANEDIOL, FORMIC ACID, ... | 著者 | Gunn, R.J, Burns, A.C, Lawson, J.D, Marx, M.A. | 登録日 | 2021-10-12 | 公開日 | 2022-11-09 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | CRYSTAL STRUCTURE OF EED WITH MRTX-1919 TO BE PUBLISHED
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7SI4
| CRYSTAL STRUCTURE OF EED WITH MRTX-2219 | 分子名称: | (4S)-8-{4-[(dimethylamino)methyl]-2-methylphenyl}-5-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}imidazo[1,2-c]pyrimidine-2-carbonitrile, FORMIC ACID, Polycomb protein EED | 著者 | Gunn, R.J, Burns, A.C, Lawson, J.D, Marx, M.A. | 登録日 | 2021-10-12 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | CRYSTAL STRUCTURE OF EED WITH MRTX-2219 TO BE PUBLISHED
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7TD3
| Sphingosine-1-phosphate receptor 1-Gi complex bound to S1P | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | 登録日 | 2021-12-30 | 公開日 | 2022-02-09 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun, 13, 2022
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7TD4
| Sphingosine-1-phosphate receptor 1-Gi complex bound to Siponimod | 分子名称: | 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | 登録日 | 2021-12-30 | 公開日 | 2022-02-09 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun, 13, 2022
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7M2U
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8COB
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1A6R
| GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A | 分子名称: | GAL6, SULFATE ION | 著者 | Joshua-Tor, L, Zheng, W, Johnston, S.A. | 登録日 | 1998-02-27 | 公開日 | 1998-10-21 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase. Cell(Cambridge,Mass.), 93, 1998
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5HYN
| Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide | 分子名称: | H3K27M, Histone-lysine N-methyltransferase EZH2, JARID2 K116me3, ... | 著者 | Zhang, Y, Justin, N, Wilson, J.R, Gamblin, S.J. | 登録日 | 2016-02-01 | 公開日 | 2016-05-11 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2. Nat Commun, 7, 2016
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7X3T
| Cryo-EM structure of ISW1a-dinucleosome | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (343-MER), ... | 著者 | Lifei, L, Kangjing, C, Chen, Z. | 登録日 | 2022-03-01 | 公開日 | 2023-09-20 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | 主引用文献 | Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
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7X3X
| Cryo-EM structure of N1 nucleosome-RA | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | 著者 | Lifei, L, Kangjing, C, Chen, Z. | 登録日 | 2022-03-01 | 公開日 | 2023-09-20 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
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7X3W
| Cryo-EM structure of ISW1-N1 nucleosome | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (146-MER), ... | 著者 | Lifei, L, Kangjing, C, Chen, Z. | 登録日 | 2022-03-01 | 公開日 | 2023-09-20 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
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6IRO
| the crosslinked complex of ISWI-nucleosome in the ADP-bound state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (167-MER), Histone H2A, ... | 著者 | Yan, L.J, Wu, H, Li, X.M, Gao, N, Chen, Z.C. | 登録日 | 2018-11-13 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling. Nat. Struct. Mol. Biol., 26, 2019
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8HY0
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8HXY
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8IHT
| Rpd3S bound to the nucleosome | 分子名称: | CALCIUM ION, Chromatin modification-related protein EAF3, DNA (164-MER), ... | 著者 | Zhang, Y, Gang, C. | 登録日 | 2023-02-23 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | 主引用文献 | Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme. Cell Res., 33, 2023
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8JHO
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8OL1
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6K1P
| The complex of ISWI-nucleosome in the ADP.BeF-bound state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (167-MER), ... | 著者 | Yan, L.J, Wu, H, Li, X.M, Gao, N, Chen, Z.C. | 登録日 | 2019-05-10 | 公開日 | 2019-05-29 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling. Nat.Struct.Mol.Biol., 26, 2019
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6JYL
| The crosslinked complex of ISWI-nucleosome in the ADP.BeF-bound state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (167-MER), ... | 著者 | Yan, L.J, Wu, H, Li, X.M, Gao, N, Chen, Z.C. | 登録日 | 2019-04-26 | 公開日 | 2019-05-29 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling. Nat.Struct.Mol.Biol., 26, 2019
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3KAH
| Structure-guided design of alpha-amino acid-derived Pin1 inhibitors | 分子名称: | 3-(1H-benzimidazol-2-yl)-N-[(1-methyl-3-phenyl-1H-pyrazol-5-yl)carbonyl]-D-alanine, DODECAETHYLENE GLYCOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 著者 | Baker, L.M, Dokurno, P, Robinson, D.A, Surgenor, A.E, Murray, J.B, Potter, A.J, Moore, J.D. | 登録日 | 2009-10-19 | 公開日 | 2009-12-22 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-guided design of alpha-amino acid-derived Pin1 inhibitors Bioorg.Med.Chem.Lett., 20, 2010
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3JVF
| Crystal structure of an Interleukin-17 receptor complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Ely, L.K, Garcia, K.C. | 登録日 | 2009-09-16 | 公開日 | 2009-10-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural basis of receptor sharing by interleukin 17 cytokines. Nat.Immunol., 10, 2009
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3BYH
| Model of actin-fimbrin ABD2 complex | 分子名称: | Actin, fimbrin ABD2 | 著者 | Galkin, V.E, Orlova, A, Cherepanova, O, Lebart, M.C, Egelman, E.H. | 登録日 | 2008-01-16 | 公開日 | 2008-02-19 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (12 Å) | 主引用文献 | High-resolution cryo-EM structure of the F-actin-fimbrin/plastin ABD2 complex. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3BZH
| Crystal structure of human ubiquitin-conjugating enzyme E2 E1 | 分子名称: | GLYCEROL, Ubiquitin-conjugating enzyme E2 E1 | 著者 | Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2008-01-18 | 公開日 | 2008-02-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Mol Cell Proteomics, 11, 2012
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