7W77
| cryo-EM structure of human NaV1.3/beta1/beta2-bulleyaconitineA | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jiang, D, Li, X. | 登録日 | 2021-12-03 | 公開日 | 2022-04-06 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for modulation of human Na V 1.3 by clinical drug and selective antagonist. Nat Commun, 13, 2022
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7W6T
| CryoEM structure of human KChIP1-Kv4.3-DPP6 complex | 分子名称: | Dipeptidyl aminopeptidase-like protein 6, Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 1 | 著者 | Ma, D.M, Guo, J.T. | 登録日 | 2021-12-02 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | 主引用文献 | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res., 32, 2022
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7W6S
| CryoEM structure of human KChIP2-Kv4.3 complex | 分子名称: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 2 | 著者 | Ma, D.M, Guo, J.T. | 登録日 | 2021-12-02 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res., 32, 2022
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7W6N
| CryoEM structure of human KChIP1-Kv4.3 complex | 分子名称: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 1 | 著者 | Ma, D.M, Guo, J.T. | 登録日 | 2021-12-02 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res., 32, 2022
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7W5Z
| Cryo-EM structure of Tetrahymena thermophila mitochondrial complex IV, composite dimer model | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-oxoglutarate/malate carrier protein, CARDIOLIPIN, ... | 著者 | Zhou, L, Maldonado, M, Padavannil, A, Letts, J. | 登録日 | 2021-11-30 | 公開日 | 2022-04-06 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | Structures of Tetrahymena 's respiratory chain reveal the diversity of eukaryotic core metabolism. Science, 376, 2022
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7W3Y
| CryoEM structure of human Kv4.3 | 分子名称: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3 | 著者 | Ma, D.M, Guo, J.T. | 登録日 | 2021-11-26 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res., 32, 2022
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7VQ2
| Structure of Apo-hsTRPM2 channel TM domain | 分子名称: | Transient receptor potential cation channel subfamily M member 2 | 著者 | Yu, X.F, Xie, Y, Zhang, X.K, Ma, C, Guo, J.T, Yang, F, Yang, W. | 登録日 | 2021-10-18 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | 主引用文献 | Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel. Cell Rep, 37, 2021
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7VQ1
| Structure of Apo-hsTRPM2 channel | 分子名称: | Transient receptor potential cation channel subfamily M member 2 | 著者 | Yu, X.F, Xie, Y, Zhang, X.K, Ma, C, Guo, J.T, Yang, F, Yang, W. | 登録日 | 2021-10-18 | 公開日 | 2021-12-22 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.76 Å) | 主引用文献 | Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel. Cell Rep, 37, 2021
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7VNR
| Structure of human KCNQ4-ML213 complex in digitonin | 分子名称: | (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid, Calmodulin-3, POTASSIUM ION, ... | 著者 | Xu, F, Zheng, Y. | 登録日 | 2021-10-11 | 公開日 | 2021-12-01 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel. Neuron, 110, 2022
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7VNQ
| Structure of human KCNQ4-ML213 complex in nanodisc | 分子名称: | (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid, Calmodulin-3, POTASSIUM ION, ... | 著者 | Xu, F, Zheng, Y. | 登録日 | 2021-10-11 | 公開日 | 2021-12-01 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel. Neuron, 110, 2022
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7VNP
| Structure of human KCNQ4-ML213 complex with PIP2 | 分子名称: | (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid, Calmodulin-3, POTASSIUM ION, ... | 著者 | Xu, F, Zheng, Y. | 登録日 | 2021-10-11 | 公開日 | 2021-12-01 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel. Neuron, 110, 2022
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7VMS
| Structure of recombinant RyR2 mutant K4593A (Ca2+ dataset) | 分子名称: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | 著者 | Kobayashi, T, Tsutsumi, A, Kurebayashi, N, Kodama, M, Kikkawa, M, Murayama, T, Ogawa, H. | 登録日 | 2021-10-09 | 公開日 | 2022-08-10 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations Nat Commun, 13, 2022
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7VMR
| Structure of recombinant RyR2 mutant K4593A (EGTA dataset) | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ZINC ION | 著者 | Kobayashi, T, Tsutsumi, A, Kurebayashi, N, Kodama, M, Kikkawa, M, Murayama, T, Ogawa, H. | 登録日 | 2021-10-09 | 公開日 | 2022-08-10 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations. Nat Commun, 13, 2022
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7VMQ
| Structure of recombinant RyR2 (Ca2+ dataset, class 3, open state) | 分子名称: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | 著者 | Kobayashi, T, Tsutsumi, A, Kurebayashi, N, Kodama, M, Kikkawa, M, Murayama, T, Ogawa, H. | 登録日 | 2021-10-09 | 公開日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations Nat Commun, 13, 2022
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7VMP
| Structure of recombinant RyR2 (Ca2+ dataset, class 2, open state) | 分子名称: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | 著者 | Kobayashi, T, Tsutsumi, A, Kurebayashi, N, Kodama, M, Kikkawa, M, Murayama, T, Ogawa, H. | 登録日 | 2021-10-09 | 公開日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations. Nat Commun, 13, 2022
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7VMO
| Structure of recombinant RyR2 (Ca2+ dataset, class 1, open state) | 分子名称: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | 著者 | Kobayashi, T, Tsutsumi, A, Kurebayashi, N, Kodama, M, Kikkawa, M, Murayama, T, Ogawa, H. | 登録日 | 2021-10-09 | 公開日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations. Nat Commun, 13, 2022
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7VMN
| Structure of recombinant RyR2 (EGTA dataset, class 2, closed state) | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ZINC ION | 著者 | Kobayashi, T, Tsutsumi, A, Kurebayashi, N, Kodama, M, Kikkawa, M, Murayama, T, Ogawa, H. | 登録日 | 2021-10-09 | 公開日 | 2022-08-10 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations. Nat Commun, 13, 2022
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7VMM
| Structure of recombinant RyR2 (EGTA dataset, class 1, closed state) | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ZINC ION | 著者 | Kobayashi, T, Tsutsumi, A, Kurebayashi, N, Kodama, M, Kikkawa, M, Murayama, T, Ogawa, H. | 登録日 | 2021-10-09 | 公開日 | 2022-08-10 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations. Nat Commun, 13, 2022
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7VML
| Structure of recombinant RyR2 (EGTA dataset, class 1&2, closed state) | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ZINC ION | 著者 | Kobayashi, T, Tsutsumi, A, Kurebayashi, N, Kodama, M, Kikkawa, M, Murayama, T, Ogawa, H. | 登録日 | 2021-10-09 | 公開日 | 2022-08-10 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations. Nat Commun, 13, 2022
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7VFW
| Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to CaV2.2-blocker1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazole, CALCIUM ION, ... | 著者 | Dong, Y, Gao, Y, Wang, Y, Zhao, Y. | 登録日 | 2021-09-13 | 公開日 | 2021-11-03 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Closed-state inactivation and pore-blocker modulation mechanisms of human Ca V 2.2. Cell Rep, 37, 2021
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7VFV
| Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to PD173212 | 分子名称: | (2~{S})-~{N}-[(2~{S})-1-(~{tert}-butylamino)-1-oxidanylidene-3-(4-phenylmethoxyphenyl)propan-2-yl]-2-[(4-~{tert}-butylphenyl)methyl-methyl-amino]-4-methyl-pentanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Dong, Y, Gao, Y, Wang, Y, Zhao, Y. | 登録日 | 2021-09-13 | 公開日 | 2021-11-03 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Closed-state inactivation and pore-blocker modulation mechanisms of human Ca V 2.2. Cell Rep, 37, 2021
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7VFU
| Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to ziconotide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Dong, Y, Gao, Y, Wang, Y, Zhao, Y. | 登録日 | 2021-09-13 | 公開日 | 2021-11-03 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Closed-state inactivation and pore-blocker modulation mechanisms of human Ca V 2.2. Cell Rep, 37, 2021
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7VFS
| Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, apo state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Dong, Y, Gao, Y, Wang, Y, Zhao, Y. | 登録日 | 2021-09-13 | 公開日 | 2021-11-03 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Closed-state inactivation and pore-blocker modulation mechanisms of human Ca V 2.2. Cell Rep, 37, 2021
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7UKH
| Human Kv4.2-KChIP2-DPP6 channel complex in an open state, intracellular region | 分子名称: | CALCIUM ION, Isoform 2 of Kv channel-interacting protein 2, Potassium voltage-gated channel subfamily D member 2, ... | 著者 | Zhao, H, Dai, Y, Lee, C.H. | 登録日 | 2022-04-01 | 公開日 | 2022-06-29 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.33 Å) | 主引用文献 | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes. Mol.Cell, 82, 2022
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7UKG
| Human Kv4.2-KChIP2-DPP6 channel complex in an open state, transmembrane region | 分子名称: | Dipeptidyl-peptidase 6, POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | 著者 | Zhao, H, Dai, Y, Lee, C.H. | 登録日 | 2022-04-01 | 公開日 | 2022-06-29 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.24 Å) | 主引用文献 | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes. Mol.Cell, 82, 2022
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