8U2D
 
 | | Bruton's tyrosine kinase in complex with N-[(2R)-1-[(3R)-3-(methylcarbamoyl)-1H,2H,3H,4H,9H-pyrido[3,4-b]indol-2-yl]-3-(3-methylphenyl)-1-oxopropan-2-yl]-1H-indazole-5-carboxamide | | 分子名称: | (3R)-2-[N-(1H-indazole-5-carbonyl)-3-methyl-D-phenylalanyl]-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | 著者 | Gajewski, S, Clifton, M.C. | | 登録日 | 2023-09-05 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies.
J.Med.Chem., 67, 2024
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8D8L
 | | Yeast mitochondrial small subunit assembly intermediate (State 3) | | 分子名称: | 15S ribosomal RNA, 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial, ... | | 著者 | Burnside, C, Harper, N, Klinge, S. | | 登録日 | 2022-06-08 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Principles of mitoribosomal small subunit assembly in eukaryotes.
Nature, 614, 2023
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2JTN
 | | NMR Solution Structure of a ldb1-LID:Lhx3-LIM complex | | 分子名称: | LIM domain-binding protein 1, LIM/homeobox protein Lhx3, ZINC ION | | 著者 | Lee, C, Nancarrow, A.L, Mackay, J.P, Matthews, J.M. | | 登録日 | 2007-08-03 | | 公開日 | 2008-06-17 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes
Embo J., 27, 2008
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6SXR
 | | E221Q mutant of GH54 a-l-arabinofuranosidase soaked with 4-nitrophenyl a-l-arabinofuranoside | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | McGregor, N.G.S, Davies, G.J, Nin-Hill, A, Rovira, C. | | 登録日 | 2019-09-26 | | 公開日 | 2020-02-26 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining alpha-l-Arabinofuranosidases.
J.Am.Chem.Soc., 142, 2020
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3IA7
 | | Crystal Structure of CalG4, the Calicheamicin Glycosyltransferase | | 分子名称: | CALCIUM ION, CHLORIDE ION, CalG4 | | 著者 | Chang, A, Singh, S, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N. | | 登録日 | 2009-07-13 | | 公開日 | 2010-06-02 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.
Proc.Natl.Acad.Sci.USA, 108, 2011
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5HMX
 | | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 10 | | 分子名称: | 2,2'-(5-(thiophen-2-yl)-1,3-phenylene)diacetic acid, RNA-directed RNA polymerase NS5, ZINC ION | | 著者 | Noble, C.G. | | 登録日 | 2016-01-17 | | 公開日 | 2016-03-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design
J.Med.Chem., 59, 2016
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5CTY
 | | Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3-[2-(pyridin-3-yl)-1,3-thiazol-5-yl]-2,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one, CHLORIDE ION, ... | | 著者 | Andersen, O.A, Barker, J, Cheng, R.K, Kahmann, J, Felicetti, B, Wood, M, Scheich, C, Mesleh, M, Cross, J.B, Zhang, J, Yang, Q, Lippa, B, Ryan, M.D. | | 登録日 | 2015-07-24 | | 公開日 | 2016-02-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB.
Bioorg.Med.Chem.Lett., 26, 2016
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2C0H
 | | X-ray structure of beta-mannanase from blue mussel Mytilus edulis | | 分子名称: | MANNAN ENDO-1,4-BETA-MANNOSIDASE, SULFATE ION | | 著者 | Larsson, A.M, Anderson, L, Xu, B, Munoz, I.G, Uson, I, Janson, J.-C, Stalbrand, H, Stahlberg, J. | | 登録日 | 2005-09-02 | | 公開日 | 2006-02-22 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Three-Dimensional Crystal Structure and Enzymic Characterization of Beta-Mannanase Man5A from Blue Mussel Mytilus Edulis.
J.Mol.Biol., 357, 2006
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2BNX
 | | Crystal structure of the dimeric regulatory domain of mouse diaphaneous-related formin (DRF), mDia1 | | 分子名称: | CHLORIDE ION, DIAPHANOUS PROTEIN HOMOLOG 1 | | 著者 | Otomo, T, Otomo, C, Tomchick, D.R, Machius, M, Rosen, M.K. | | 登録日 | 2005-04-05 | | 公開日 | 2005-06-13 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural Basis of Rho Gtpase-Mediated Activation of the Formin Mdia1
Mol.Cell, 18, 2005
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6UVM
 | | Cocrystal of BRD4(D1) with a methyl carbamate thiazepane inhibitor | | 分子名称: | 1,2-ETHANEDIOL, 1-[(7S)-7-(thiophen-2-yl)-6,7-dihydro-1,4-thiazepin-4(5H)-yl]ethan-1-one, Bromodomain-containing protein 4 | | 著者 | Johnson, J.A, Pomerantz, W.C.K. | | 登録日 | 2019-11-03 | | 公開日 | 2020-01-01 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains.
Acs Med.Chem.Lett., 10, 2019
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7W96
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6J2Z
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7VVH
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1BWI
 | | THE 1.8 A STRUCTURE OF MICROBATCH OIL DROP GROWN TETRAGONAL HEN EGG WHITE LYSOZYME | | 分子名称: | PROTEIN (LYSOZYME) | | 著者 | Dong, J, Boggon, T.J, Chayen, N.E, Raftery, J, Bi, R.C. | | 登録日 | 1998-09-24 | | 公開日 | 1998-09-30 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Bound-solvent structures for microgravity-, ground control-, gel- and microbatch-grown hen egg-white lysozyme crystals at 1.8 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
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3GB2
 | | GSK3beta inhibitor complex | | 分子名称: | 2-methyl-5-(3-{4-[(S)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole, Glycogen synthase kinase-3 beta | | 著者 | Mol, C.D. | | 登録日 | 2009-02-18 | | 公開日 | 2010-03-02 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | 2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability.
J.Med.Chem., 52, 2009
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6UYZ
 | | Crystal structure of K46-acetylated SUMO1 in complex with phosphorylated DAXX | | 分子名称: | Small ubiquitin-related modifier 1, phosphorylated DAXX | | 著者 | Wahba, H.M, Gagnon, C, Mascle, X.H, Lussier-Price, M, Cappadocia, L, Sakaguchi, K, Omichinski, J.G. | | 登録日 | 2019-11-14 | | 公開日 | 2019-11-27 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner.
Structure, 28, 2020
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5HJ5
 | | Crystal structure of tertiary complex of glucosamine-6-phosphate deaminase from Vibrio cholerae with BETA-D-GLUCOSE-6-PHOSPHATE and FRUCTOSE-6-PHOSPHATE | | 分子名称: | 6-O-phosphono-beta-D-glucopyranose, ACETIC ACID, FRUCTOSE -6-PHOSPHATE, ... | | 著者 | Chang, C, Maltseva, N, Kim, Y, Kwon, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2016-01-12 | | 公開日 | 2016-02-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of tertiary complex of glucosamine-6-phosphate deaminase from Vibrio cholerae with BETA-D-GLUCOSE-6-PHOSPHATE and FRUCTOSE -6-PHOSPHATE
To Be Published
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5CVN
 | | WDR48 (2-580):USP46~ubiquitin ternary complex | | 分子名称: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, WD repeat-containing protein 48, ... | | 著者 | Harris, S.F, Yin, J. | | 登録日 | 2015-07-27 | | 公開日 | 2015-10-07 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3.36 Å) | | 主引用文献 | Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.
Structure, 23, 2015
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2N4D
 | | EC-NMR Structure of Agrobacterium tumefaciens Atu1203 Determined by Combining Evolutionary Couplings (EC) and Sparse NMR Data. Northeast Structural Genomics Consortium target AtT10 | | 分子名称: | Uncharacterized protein Atu1203 | | 著者 | Tang, Y, Huang, Y.J, Hopf, T.A, Sander, C, Marks, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2015-06-17 | | 公開日 | 2015-07-01 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Protein structure determination by combining sparse NMR data with evolutionary couplings.
Nat.Methods, 12, 2015
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5OJZ
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2N0S
 | | HADDOCK model of ferredoxin and [FeFe] hydrogenase complex | | 分子名称: | FE2/S2 (INORGANIC) CLUSTER, Fe-hydrogenase, Ferredoxin, ... | | 著者 | Rumpel, S, Siebel, J, Fares, C, Reijerse, E, Lubitz, W. | | 登録日 | 2015-03-13 | | 公開日 | 2015-06-24 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Insight into the Complex of Ferredoxin and [FeFe] Hydrogenase from Chlamydomonas reinhardtii.
Chembiochem, 16, 2015
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2JXF
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8HY8
 | | Bacterial STING from Epilithonimonas lactis | | 分子名称: | CD-NTase-associated protein 12 | | 著者 | Wang, Y.-C, Yang, C.-S, Hou, M.-H, Chen, Y. | | 登録日 | 2023-01-06 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.568 Å) | | 主引用文献 | Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING.
Nat Commun, 14, 2023
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8D8K
 | | Yeast mitochondrial small subunit assembly intermediate (State 2) | | 分子名称: | 15S ribosomal RNA, 37S ribosomal protein MRP1, mitochondrial, ... | | 著者 | Burnside, C, Harper, N.J, Klinge, S. | | 登録日 | 2022-06-08 | | 公開日 | 2022-12-21 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | | 主引用文献 | Principles of mitoribosomal small subunit assembly in eukaryotes.
Nature, 614, 2023
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4XEG
 | | Structure of the enzyme-product complex resulting from TDG action on a G/hmU mismatch | | 分子名称: | 1,2-ETHANEDIOL, ACETIC ACID, DNA (28-MER), ... | | 著者 | Pozharski, E, Malik, S.S, Drohat, A.C. | | 登録日 | 2014-12-23 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA.
Nucleic Acids Res., 43, 2015
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