3GB2

GSK3beta inhibitor complex

Summary for 3GB2

Entry DOI	10.2210/pdb3gb2/pdb
Related	3F7Z 3F88
Descriptor	Glycogen synthase kinase-3 beta, 2-methyl-5-(3-{4-[(S)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole (3 entities in total)
Functional Keywords	protein kinase, inhibitor, complex, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, wnt signaling pathway, cdm
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P49841
Total number of polymer chains	1
Total formula weight	40424.37
Authors	Mol, C.D. (deposition date: 2009-02-18, release date: 2010-03-02, Last modification date: 2023-11-22)
Primary citation	Saitoh, M.,Kunitomo, J.,Kimura, E.,Iwashita, H.,Uno, Y.,Onishi, T.,Uchiyama, N.,Kawamoto, T.,Tanaka, T.,Mol, C.D.,Dougan, D.R.,Textor, G.P.,Snell, G.P.,Takizawa, M.,Itoh, F.,Kori, M. 2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability. J.Med.Chem., 52:6270-6286, 2009 Cited by PubMed: 19775160 DOI: 10.1021/jm900647e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation