5CTY
Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment
Summary for 5CTY
Entry DOI | 10.2210/pdb5cty/pdb |
Related | 5CPH 5CTU 5CTW 5CTX |
Descriptor | DNA gyrase subunit B, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | dna gyrase, gyrb, fragment-based screening, structure-based design, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
Biological source | Staphylococcus aureus |
Cellular location | Cytoplasm : P0A0K8 |
Total number of polymer chains | 2 |
Total formula weight | 48868.91 |
Authors | Andersen, O.A.,Barker, J.,Cheng, R.K.,Kahmann, J.,Felicetti, B.,Wood, M.,Scheich, C.,Mesleh, M.,Cross, J.B.,Zhang, J.,Yang, Q.,Lippa, B.,Ryan, M.D. (deposition date: 2015-07-24, release date: 2016-02-03, Last modification date: 2023-09-27) |
Primary citation | Mesleh, M.F.,Cross, J.B.,Zhang, J.,Kahmann, J.,Andersen, O.A.,Barker, J.,Cheng, R.K.,Felicetti, B.,Wood, M.,Hadfield, A.T.,Scheich, C.,Moy, T.I.,Yang, Q.,Shotwell, J.,Nguyen, K.,Lippa, B.,Dolle, R.,Ryan, M.D. Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB. Bioorg.Med.Chem.Lett., 26:1314-1318, 2016 Cited by PubMed: 26786695DOI: 10.1016/j.bmcl.2016.01.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report