4MYO
| Crystal structure of streptogramin group A antibiotic acetyltransferase VatA from Staphylococcus aureus | 分子名称: | CHLORIDE ION, MAGNESIUM ION, SULFATE ION, ... | 著者 | Stogios, P.J, Minasov, G, Dong, A, Evdokimova, E, Yim, V, Krishnamoorthy, M, Di Leo, R, Courvalin, P, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2013-09-27 | 公開日 | 2013-10-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.696 Å) | 主引用文献 | Potential for Reduction of Streptogramin A Resistance Revealed by Structural Analysis of Acetyltransferase VatA. Antimicrob.Agents Chemother., 58, 2014
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2Z2H
| NMR Structure of the IQ-modified Dodecamer CTCG[IQ]GCGCCATC | 分子名称: | 3-METHYL-3H-IMIDAZO[4,5-F]QUINOLIN-2-AMINE, DNA (5'-D(*DCP*DTP*DCP*DGP*DGP*DCP*DGP*DCP*DCP*DAP*DTP*DC)-3'), DNA (5'-D(*DGP*DAP*DTP*DGP*DGP*DCP*DGP*DCP*DCP*DGP*DAP*DG)-3') | 著者 | Wang, F, Elmquist, C.E, Stover, J.S, Rizzo, C.J, Stone, M.P. | 登録日 | 2007-05-22 | 公開日 | 2007-10-02 | 最終更新日 | 2023-11-29 | 実験手法 | SOLUTION NMR | 主引用文献 | DNA sequence modulates the conformation of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme Biochemistry, 46, 2007
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5U7A
| Crystal structure of a complex formed between MerB and Dimethyltin | 分子名称: | Alkylmercury lyase, BROMIDE ION, Dimethyltin dibromide, ... | 著者 | Wahba, H.M, Stevenson, M, Mansour, A, Sygusch, J, Wilcox, D.E, Omichinski, J.G. | 登録日 | 2016-12-12 | 公開日 | 2017-01-11 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.532 Å) | 主引用文献 | Structural and Biochemical Characterization of Organotin and Organolead Compounds Binding to the Organomercurial Lyase MerB Provide New Insights into Its Mechanism of Carbon-Metal Bond Cleavage. J. Am. Chem. Soc., 139, 2017
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3M5L
| Crystal structure of HCV NS3/4A protease in complex with ITMN-191 | 分子名称: | (2R,6S,12Z,13aS,14aR,16aS)-6-[(tert-butoxycarbonyl)amino]-14a-[(cyclopropylsulfonyl)carbamoyl]-5,16-dioxo-1,2,3,5,6,7,8 ,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoro-2H-isoindole-2-carboxylate, NS3/4A, SULFATE ION, ... | 著者 | Schiffer, C.A, Romano, K.P. | 登録日 | 2010-03-12 | 公開日 | 2010-11-24 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding. Proc.Natl.Acad.Sci.USA, 107, 2010
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2WQD
| Crystal structure of enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system in the dephosphorylated state | 分子名称: | CALCIUM ION, PHOSPHOENOLPYRUVATE-PROTEIN PHOSPHOTRANSFERASE | 著者 | Oberholzer, A.E, Schneider, P, Siebold, C, Baumann, U, Erni, B. | 登録日 | 2009-08-19 | 公開日 | 2009-10-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure of Enzyme I of the Phosphoenolpyruvate:Sugar Phosphotransferase System in the Dephosphorylated State. J.Biol.Chem., 284, 2009
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5U7C
| Crystal structure of the lead-bound form of MerB formed from diethyllead. | 分子名称: | ACETATE ION, Alkylmercury lyase, BROMIDE ION, ... | 著者 | Wahba, H.M, Stevenson, M, Mansour, A, Sygusch, J, Wilcox, D.E, Omichinski, J.G. | 登録日 | 2016-12-12 | 公開日 | 2017-01-11 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural and Biochemical Characterization of Organotin and Organolead Compounds Binding to the Organomercurial Lyase MerB Provide New Insights into Its Mechanism of Carbon-Metal Bond Cleavage. J. Am. Chem. Soc., 139, 2017
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5U82
| Crystal structure of a MerB-triethyltin complex | 分子名称: | ACETATE ION, Alkylmercury lyase, BROMIDE ION, ... | 著者 | Wahba, H.M, Stevenson, M, Mansour, A, Sygusch, J, Wilcox, D.E, Omichinski, J.G. | 登録日 | 2016-12-13 | 公開日 | 2017-01-11 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.851 Å) | 主引用文献 | Structural and Biochemical Characterization of Organotin and Organolead Compounds Binding to the Organomercurial Lyase MerB Provide New Insights into Its Mechanism of Carbon-Metal Bond Cleavage. J. Am. Chem. Soc., 139, 2017
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2PJD
| Crystal structure of 16S rRNA methyltransferase RsmC | 分子名称: | Ribosomal RNA small subunit methyltransferase C | 著者 | Sunita, S, Purta, E, Durawa, M, Tkaczuk, K.L, Bujnicki, J.M, Sivaraman, J. | 登録日 | 2007-04-16 | 公開日 | 2007-07-03 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC Nucleic Acids Res., 35, 2007
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5TPU
| x-ray structure of the WlaRB TDP-quinovose 3,4-ketoisomerase from campylobacter jejuni | 分子名称: | CHLORIDE ION, Putative uncharacterized protein, THYMIDINE-5'-DIPHOSPHATE | 著者 | Holden, H.M, Thoden, J.B, Li, J.Z, Riegert, A.S, Goneau, M.-F, Cunningham, A.M, Vinogradov, E, Schoenhofen, I.C, Gilbert, M. | 登録日 | 2016-10-21 | 公開日 | 2017-02-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Characterization of the dTDP-Fuc3N and dTDP-Qui3N biosynthetic pathways in Campylobacter jejuni 81116. Glycobiology, 27, 2017
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3WYY
| CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH (E)-3-(4-((6-(((3s,5s,7s)-adamantan-1-yl)amino)-4-amino-5-cyanopyridin-2-yl)amino)-2-(cyanomethoxy)phenyl)-N-(2-methoxyethyl)acrylamide | 分子名称: | (2E)-3-[4-({4-amino-5-cyano-6-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-ylamino]pyridin-2-yl}amino)-2-(cyanomethoxy)phenyl]-N-(2-methoxyethyl)prop-2-enamide, Dual specificity protein kinase TTK | 著者 | Kusakabe, K, Ide, N, Daigo, Y, Itoh, T, Yamamoto, T, Kojima, E, Mitsuoka, Y, Tadano, G, Tagashira, S, Higashino, K, Okano, Y, Sato, Y, Inoue, M, Iguchi, M, Kanazawa, T, Ishioka, Y, Dohi, K, Kido, Y, Sakamoto, S, Ando, S, Maeda, M, Higaki, M, Yoshizawa, H, Murai, H, Nakamura, Y. | 登録日 | 2014-09-10 | 公開日 | 2015-04-08 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity. Bioorg.Med.Chem., 23, 2015
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5V6V
| Crystal structure of small molecule aziridine 3 covalently bound to K-Ras G12C | 分子名称: | 3-amino-1-{4-[6-chloro-8-fluoro-7-(5-methyl-1H-indazol-4-yl)quinazolin-4-yl]piperazin-1-yl}propan-1-one, CALCIUM ION, GLYCEROL, ... | 著者 | McGregor, L.M, Jenkins, M, Kerwin, C, Burke, J.E, Shokat, K.M. | 登録日 | 2017-03-17 | 公開日 | 2017-06-28 | 最終更新日 | 2019-11-20 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes. Biochemistry, 56, 2017
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3DF9
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3DDL
| Crystallographic Structure of Xanthorhodopsin, a Light-Driven Ion Pump with Dual Chromophore | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, RETINAL, ... | 著者 | Stagno, J, Luecke, H, Schobert, B, Lanyi, J.K, Imasheva, E.S, Wang, J.M, Balashov, S.P. | 登録日 | 2008-06-05 | 公開日 | 2008-10-14 | 最終更新日 | 2016-06-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystallographic structure of xanthorhodopsin, the light-driven proton pump with a dual chromophore. Proc.Natl.Acad.Sci.USA, 105, 2008
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3DCJ
| Crystal structure of glycinamide formyltransferase (PurN) from Mycobacterium tuberculosis in complex with 5-methyl-5,6,7,8-tetrahydrofolic acid derivative | 分子名称: | CHLORIDE ION, MAGNESIUM ION, N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID, ... | 著者 | Zhang, Z, Squire, C.J, Baker, E.N. | 登録日 | 2008-06-03 | 公開日 | 2009-05-12 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery. J.Mol.Biol., 389, 2009
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5TDE
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1JQJ
| Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III: Structure of the beta-delta complex | 分子名称: | DNA polymerase III, beta chain, delta subunit | 著者 | Jeruzalmi, D, Yurieva, O, Zhao, Y, Young, M, Stewart, J, Hingorani, M, O'Donnell, M, Kuriyan, J. | 登録日 | 2001-08-07 | 公開日 | 2001-11-07 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Mechanism of processivity clamp opening by the delta subunit wrench of the clamp loader complex of E. coli DNA polymerase III. Cell(Cambridge,Mass.), 106, 2001
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4N6L
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3OLQ
| The crystal structure of a universal stress protein E from Proteus mirabilis HI4320 | 分子名称: | ACETATE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Tan, K, Chhor, G, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2010-08-26 | 公開日 | 2010-09-22 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.816 Å) | 主引用文献 | The crystal structure of a universal stress protein E from
Proteus mirabilis HI4320 To be Published
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3PCO
| crystal structure of E. coli phenylalanine-tRNA synthetase complexed with phenylalanine and AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, PHENYLALANINE, Phenylalanyl-tRNA synthetase, ... | 著者 | Mermershtain, I, Finarov, I, Klipcan, L, Kessler, N, Rozenberg, H, Safro, M.G. | 登録日 | 2010-10-21 | 公開日 | 2011-03-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | 主引用文献 | Idiosyncrasy and identity in the prokaryotic phe-system: crystal structure of E. coli phenylalanyl-tRNA synthetase complexed with phenylalanine and AMP. Protein Sci., 20, 2011
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3PGR
| Asp348Arg mutant of EcFadL | 分子名称: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, Long-chain fatty acid transport protein | 著者 | Lepore, B.W, van den Berg, B, Indic, M, Hearn, E, Patel, D, Pham, H. | 登録日 | 2010-11-02 | 公開日 | 2011-05-25 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | From the Cover: Ligand-gated diffusion across the bacterial outer membrane. Proc.Natl.Acad.Sci.USA, 108, 2011
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3GMC
| Crystal Structure of 2-Methyl-3-hydroxypyridine-5-carboxylic acid Oxygenase with substrate bound | 分子名称: | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase, 5-hydroxy-6-methylpyridine-3-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | McCulloch, K.M, Mukherjee, T, Begley, T.P, Ealick, S.E. | 登録日 | 2009-03-13 | 公開日 | 2009-04-14 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of the PLP degradative enzyme 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti MAFF303099 and its mechanistic implications. Biochemistry, 48, 2009
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4OBY
| Crystal Structure of E.coli Arginyl-tRNA Synthetase and Ligand Binding Studies Revealed Key Residues in Arginine Recognition | 分子名称: | ARGININE, Arginine--tRNA ligase | 著者 | Bi, K, Zheng, Y, Dong, J, Gao, F, Wang, J, Wang, Y, Gong, W. | 登録日 | 2014-01-08 | 公開日 | 2014-02-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.574 Å) | 主引用文献 | Crystal structure of E. coli arginyl-tRNA synthetase and ligand binding studies revealed key residues in arginine recognition. Protein Cell, 5, 2014
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4PS2
| Structure of the C-terminal fragment (87-165) of E.coli EAEC TssB molecule | 分子名称: | CHLORIDE ION, Putative type VI secretion protein, ZINC ION | 著者 | Douzi, B, Logger, L, Spinelli, S, Blangy, S, Cambillau, C, Cascales, E. | 登録日 | 2014-03-06 | 公開日 | 2015-03-11 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mapping the tube-sheath interface within the Type VI secretion system tail To be Published
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3QJO
| Refined Structure of the functional unit (KLH1-H) of keyhole limpet hemocyanin | 分子名称: | COPPER (II) ION, Hemocyanin 1 | 著者 | Jaenicke, E, Buchler, K, Decker, H, Markl, J, Schroder, G.F. | 登録日 | 2011-01-30 | 公開日 | 2011-05-25 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | The refined structure of functional unit h of keyhole limpet hemocyanin (KLH1-h) reveals disulfide bridges. Iubmb Life, 63, 2011
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3QIO
| Crystal Structure of HIV-1 RNase H with engineered E. coli loop and N-hydroxy quinazolinedione inhibitor | 分子名称: | 3-hydroxy-6-(phenylsulfonyl)quinazoline-2,4(1H,3H)-dione, Gag-Pol polyprotein,Ribonuclease HI,Gag-Pol polyprotein, MANGANESE (II) ION, ... | 著者 | Lansdon, E.B, Liu, Q. | 登録日 | 2011-01-27 | 公開日 | 2011-04-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.4011 Å) | 主引用文献 | Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors. Antimicrob.Agents Chemother., 55, 2011
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