5V6V

Crystal structure of small molecule aziridine 3 covalently bound to K-Ras G12C

Summary for 5V6V

• Entry DOI: 10.2210/pdb5v6v/pdb
• Related: 5v6s
• Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: k-ras g12c, covalent inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 40860.39

Authors

McGregor, L.M.,Jenkins, M.,Kerwin, C.,Burke, J.E.,Shokat, K.M. (deposition date: 2017-03-17, release date: 2017-06-28, Last modification date: 2019-11-20)

• Primary citation: McGregor, L.M.,Jenkins, M.L.,Kerwin, C.,Burke, J.E.,Shokat, K.M.; Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes.; Biochemistry, 56:3178-3183, 2017; PubMed: 28621541; DOI: 10.1021/acs.biochem.7b00271

Experimental method

X-RAY DIFFRACTION (1.72 Å)