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5V6V

Crystal structure of small molecule aziridine 3 covalently bound to K-Ras G12C

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007165biological_processsignal transduction
A0016020cellular_componentmembrane
B0003924molecular_functionGTPase activity
B0005525molecular_functionGTP binding
B0007165biological_processsignal transduction
B0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues26
Detailsbinding site for residue GDP A 201
ChainResidue
AGLY13
AGLU31
AARG73
AASN116
ALYS117
AASP119
ALEU120
ASER145
AALA146
ALYS147
ACA202
AVAL14
AHOH303
AHOH312
AHOH314
AHOH328
AHOH348
AHOH353
AHOH370
AGLY15
ALYS16
ASER17
AALA18
APHE28
AVAL29
AASP30

site_idAC2
Number of Residues6
Detailsbinding site for residue CA A 202
ChainResidue
ASER17
AGDP201
AHOH319
AHOH340
AHOH348
AHOH430

site_idAC3
Number of Residues6
Detailsbinding site for residue CA A 203
ChainResidue
AGLU63
AGLY138
AHOH318
AHOH380
AHOH397
AHOH443

site_idAC4
Number of Residues12
Detailsbinding site for residue 8YA A 204
ChainResidue
ACYS12
AALA59
AGLY60
ATYR64
AARG68
AASP69
AMET72
AHIS95
ATYR96
AGLN99
AVAL103
AHOH320

site_idAC5
Number of Residues4
Detailsbinding site for residue CA B 201
ChainResidue
AHOH350
AHOH388
BASP108
BHOH400

site_idAC6
Number of Residues24
Detailsbinding site for residue GDP B 202
ChainResidue
BGLY13
BVAL14
BGLY15
BLYS16
BSER17
BALA18
BPHE28
BVAL29
BASP30
BASN116
BLYS117
BASP119
BLEU120
BSER145
BALA146
BLYS147
BCA203
BHOH319
BHOH327
BHOH329
BHOH338
BHOH366
BHOH372
BHOH377

site_idAC7
Number of Residues6
Detailsbinding site for residue CA B 203
ChainResidue
BSER17
BGDP202
BHOH318
BHOH319
BHOH326
BHOH327

site_idAC8
Number of Residues5
Detailsbinding site for residue CA B 204
ChainResidue
BGLU63
BGLY138
BHOH310
BHOH358
BHOH401

site_idAC9
Number of Residues2
Detailsbinding site for residue CA B 205
ChainResidue
BGLU3
BGLU76

site_idAD1
Number of Residues7
Detailsbinding site for residue GOL B 206
ChainResidue
AILE21
AGLN25
AHIS27
ATYR32
ATYR40
BGLN25
BHOH379

site_idAD2
Number of Residues12
Detailsbinding site for Di-peptide 8YA B 207 and CYS B 12
ChainResidue
BGLY13
BVAL14
BALA59
BGLY60
BGLN61
BTYR64
BARG68
BASP69
BMET72
BTYR96
BGLN99
BALA11

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140
ChainResidueDetails
AGLY10
AVAL29
AALA59
AASN116
BGLY10
BVAL29
BALA59
BASN116

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17
ChainResidueDetails
AMET1
BMET1

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17
ChainResidueDetails
ATHR2
BTHR2

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22711838
ChainResidueDetails
ALYS104
BLYS104

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486
ChainResidueDetails
ATHR35
BTHR35

222624

PDB entries from 2024-07-17

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