3M5L
Crystal structure of HCV NS3/4A protease in complex with ITMN-191
Summary for 3M5L
| Entry DOI | 10.2210/pdb3m5l/pdb |
| Related | 3M5M 3M5N 3M5O |
| Descriptor | NS3/4A, (2R,6S,12Z,13aS,14aR,16aS)-6-[(tert-butoxycarbonyl)amino]-14a-[(cyclopropylsulfonyl)carbamoyl]-5,16-dioxo-1,2,3,5,6,7,8 ,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoro-2H-isoindole-2-carboxylate, SULFATE ION, ... (5 entities in total) |
| Functional Keywords | hcv, hepatitis c virus, ns3, protease, drug resistance, serine protease, chimera protein, fusion protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Hepatitis C virus subtype 1a (HCV) More |
| Cellular location | Virion : A8DG50 |
| Total number of polymer chains | 1 |
| Total formula weight | 22378.62 |
| Authors | Schiffer, C.A.,Romano, K.P. (deposition date: 2010-03-12, release date: 2010-11-24, Last modification date: 2024-02-21) |
| Primary citation | Romano, K.P.,Ali, A.,Royer, W.E.,Schiffer, C.A. Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding. Proc.Natl.Acad.Sci.USA, 107:20986-20991, 2010 Cited by PubMed: 21084633DOI: 10.1073/pnas.1006370107 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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