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3M5L

Crystal structure of HCV NS3/4A protease in complex with ITMN-191

Functional Information from GO Data
ChainGOidnamespacecontents
A0006508biological_processproteolysis
A0008236molecular_functionserine-type peptidase activity
A0019087biological_processtransformation of host cell by virus
Functional Information from PDB Data
site_idAC1
Number of Residues27
DetailsBINDING SITE FOR RESIDUE TSV A 100
ChainResidue
AHOH35
AGLN1041
APHE1043
AHIS1057
AGLY1058
AVAL1078
AASP1079
AASP1081
AARG1123
ALEU1135
ALYS1136
AHOH59
AGLY1137
ASER1138
AALA1139
APHE1154
AARG1155
AALA1156
AALA1157
AASP1168
AHOH78
AHOH85
AHOH86
AHOH92
AHOH141
AHOH152
AHIS982

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 A 2
ChainResidue
AHOH5
AHOH7
AHOH11
AHOH61
AHOH70
AHOH143
ATYR1006
AGLN1008
ATYR1056

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1
ChainResidue
ACYS1097
ACYS1099
ACYS1145
AHIS1149

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PDB entries from 2024-11-06

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