PDB: 45522 件ウェブページステータス検索Chemie searchBIRD

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4O22	Binary complex of metal-free PKAc with SP20. 分子名称: Phosphorylated peptide pSP20., cAMP-dependent protein kinase catalytic subunit alpha. 著者 Das, A, Kovalevsky, A.Y, Gerlits, O, Langan, P, Heller, W.T, Keshwani, M, Taylor, S.S. 登録日 2013-12-16 公開日 2014-05-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer. Biochemistry, 53, 2014
4O2D	Crystal structure of aspartyl-tRNA synthetase from Mycobacterium smegmatis with bound aspartic acid 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ASPARTIC ACID, Aspartate--tRNA ligase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2013-12-17 公開日 2014-01-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
4NTA	Mus Musculus LTC4 synthase in apo form 分子名称: Leukotriene C4 synthase, PALMITIC ACID, SULFATE ION 著者 Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. 登録日 2013-12-02 公開日 2015-01-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Mus Musculus LTC4 synthase in apo form To be Published
4NN1	Crystal Structure of transcriptional regulator Rv1219c of Mycobacterium tuberculosis 分子名称: Transcriptional regulator 著者 Kumar, N, Radhakrishnan, A, Chou, T.-H, Yu, E. 登録日 2013-11-15 公開日 2014-02-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Crystal structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis. Protein Sci., 23, 2014
4J71	Crystal Structure of GSK3b in complex with inhibitor 1R 分子名称: (2R)-2-methyl-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one, CHLORIDE ION, Glycogen synthase kinase-3 beta, ... 著者 Zhan, C, Wang, Y, Wach, J, Sheehan, P, Zhong, C, Harris, R, Patskovsky, Y, Bishop, J, Haggarty, S, Ramek, A, Berry, K, O'Herin, C, Koehler, A.N, Hung, A.W, Young, D.W, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) 登録日 2013-02-12 公開日 2013-03-20 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Fragment-based approach using diversity-oriented synthesis yields a GSK3b inhibitor To be Published
4NRP	Crystal structure of human ALKBH5 in complex with N-oxalylglycine 分子名称: MANGANESE (II) ION, N-OXALYLGLYCINE, RNA demethylase ALKBH5 著者 Feng, C, Chen, Z, Liu, Y. 登録日 2013-11-27 公開日 2014-03-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition J.Biol.Chem., 289, 2014
4NTB	Mus Musculus LTC4 synthase in GSH complex form 分子名称: GLUTATHIONE, Leukotriene C4 synthase, NICKEL (II) ION, ... 著者 Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. 登録日 2013-12-02 公開日 2015-01-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Mus Musculus LTC4 synthase in GSH complex form To be Published
4JPX	Crystal structure of phenylalanine hydroxylase S203P mutant from Chromobacterium violaceum 分子名称: COBALT (II) ION, PHENYLALANINE, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2013-03-19 公開日 2013-08-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 An additional substrate binding site in a bacterial phenylalanine hydroxylase. Eur.Biophys.J., 42, 2013
4JL4	Crystal structure of the complex between PPARgamma LBD and the ligand LJ570 [(2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid] 分子名称: (2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid, Peroxisome proliferator-activated receptor gamma 著者 Pochetti, G, Montanari, R, Capelli, D. 登録日 2013-03-12 公開日 2014-03-12 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Identification of the First PPAR alpha / gamma Dual Agonist Able To Bind to Canonical and Alternative Sites of PPAR gamma and To Inhibit Its Cdk5-Mediated Phosphorylation. J.Med.Chem., 61, 2018
4JWH	Crystal structure of spTrm10(Full length)-SAH complex 分子名称: S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine(9)-N1)-methyltransferase 著者 Yan, W, Shao, Z. 登録日 2013-03-27 公開日 2013-10-16 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res., 42, 2014
4J9T	Crystal structure of a putative, de novo designed unnatural amino acid dependent metalloprotein, northeast structural genomics consortium target OR61 分子名称: ARSENIC, GLYCEROL, designed unnatural amino acid dependent metalloprotein 著者 Forouhar, F, Lew, S, Seetharaman, J, Mills, J.H, Khare, S.D, Everett, J.K, Baker, D, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) 登録日 2013-02-17 公開日 2013-03-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Computational design of an unnatural amino Acid dependent metalloprotein with atomic level accuracy. J.Am.Chem.Soc., 135, 2013
4JDQ	Structure of the Fluorescence Recovery Protein from Synechocystis sp PCC 6803, R60K mutant 分子名称: Slr1964 protein 著者 Sutter, M, Kerfeld, C.A. 登録日 2013-02-25 公開日 2013-05-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.52 Å) 主引用文献 Crystal structure of the FRP and identification of the active site for modulation of OCP-mediated photoprotection in cyanobacteria. Proc.Natl.Acad.Sci.USA, 110, 2013
4JF9	Crystal structure of the wild type red fluorescent protein lanRFP (Branchiostoma Lanceolatum) 分子名称: Red fluorescent protein blFP-R5 著者 Pletnev, V.Z, Pletneva, N.V, Pletnev, S.V. 登録日 2013-02-28 公開日 2013-09-18 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Structure of the red fluorescent protein from a lancelet (Branchiostoma lanceolatum): a novel GYG chromophore covalently bound to a nearby tyrosine. Acta Crystallogr.,Sect.D, 69, 2013
4JJ4	Crystal structure of a catalytic mutant of Axe2 (Axe2-D191A), an acetylxylan esterase from Geobacillus stearothermophilus 分子名称: Acetyl xylan esterase, CHLORIDE ION, GLYCEROL 著者 Lansky, S, Alalouf, O, Solomon, V, Alhassid, A, Belrahli, H, Govada, L, Chayan, N.E, Shoham, Y, Shoham, G. 登録日 2013-03-07 公開日 2014-03-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 To be published To be Published
4JQ0	Voltage-gated sodium channel 1.5 C-terminal domain in complex with FGF12B and Ca2+/calmodulin 分子名称: CALCIUM ION, Calmodulin, Fibroblast growth factor 12, ... 著者 Wang, C, Chung, B.C, Yan, H, Wang, H.G, Lee, S.Y, Pitt, G.S. 登録日 2013-03-19 公開日 2014-05-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.84 Å) 主引用文献 Structural analyses of Ca(2+)/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation. Nat Commun, 5, 2014
4CA4	Crystal structure of FimH lectin domain with the Tyr48Ala mutation, in complex with heptyl alpha-D-mannopyrannoside 分子名称: FIMH, heptyl alpha-D-mannopyranoside 著者 Rabbani, S, Bouckaert, J, Zalewski, A, Preston, R, Eid, S, Thompson, A, Puorger, C, Glockshuber, R, Ernst, B. 登録日 2013-10-06 公開日 2014-10-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding. IUCrJ, 4, 2017
4BVE	CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THIOALKYLIMIDATE FORMED FROM THIO-ACETYL-LYSINE ACS2-PEPTIDE 分子名称: 1,2-ETHANEDIOL, ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL, ... 著者 Gertz, M, Weyand, M, Steegborn, C. 登録日 2013-06-25 公開日 2013-07-17 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Ex-527 Inhibits Sirtuins by Exploiting Their Unique Nad+-Dependent Deacetylation Mechanism Proc.Natl.Acad.Sci.USA, 110, 2013
4CDD	Human DPP1 in complex with (2S)-N-((1S)-1-cyano-2-(4-(4-cyanophenyl) phenyl)ethyl)piperidine-2-carboxamide 分子名称: (2S)-N-[(2S)-1-AZANYLIDENE-3-[4-(4-CYANOPHENYL)PHENYL]PROPAN-2-YL]PIPERIDINE-2-CARBOXAMIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Debreczeni, J, Edman, K, Furber, M, Tiden, A, Gardiner, P, Mete, T, Ford, R, Millichip, I, Stein, L, Mather, A, Kinchin, E, Luckhurst, C, Cage, P, Sanghanee, H, Breed, J, Wissler, L. 登録日 2013-10-31 公開日 2014-03-19 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate. J.Med.Chem., 57, 2014
2IYS	Shikimate kinase from Mycobacterium tuberculosis in complex with shikimate, open LID (conf. A) 分子名称: (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, CHLORIDE ION, SHIKIMATE KINASE 著者 Hartmann, M.D, Bourenkov, G.P, Oberschall, A, Strizhov, N, Bartunik, H.D. 登録日 2006-07-21 公開日 2006-10-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Mechanism of Phosphoryl Transfer Catalyzed by Shikimate Kinase from Mycobacterium Tuberculosis. J.Mol.Biol., 364, 2006
4CDE	Human DPP1 in complex with 4-amino-N-((1S)-1-cyano-2-(4-(4- cyanophenyl)phenyl)ethyl)tetrahydropyran-4-carboxamide 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-AZANYL-N-[(2S)-1-AZANYLIDENE-3-[4-(4-CYANOPHENYL)PHENYL]PROPAN-2-YL]OXANE-4-CARBOXAMIDE, CHLORIDE ION, ... 著者 Debreczeni, J, Edman, K, Furber, M, Tiden, A, Gardiner, P, Mete, T, Ford, R, Millichip, I, Stein, L, Mather, A, Kinchin, E, Luckhurst, C, Cage, P, Sanghanee, H, Breed, J, Wissler, L. 登録日 2013-10-31 公開日 2014-03-19 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate. J.Med.Chem., 57, 2014
4BZ8	Crystal structure of Schistosoma mansoni HDAC8 complexed with J1038 分子名称: (2R)-2-methyl-3-oxo-4H-1,4-benzothiazine-6-carbohydroxamic acid, HISTONE DEACETYLASE 8, POTASSIUM ION, ... 著者 Marek, M, Romier, C. 登録日 2013-07-24 公開日 2013-08-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni. Plos Pathog., 9, 2013
4C13	x-ray crystal structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys 分子名称: CHLORIDE ION, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Ruane, K.M, Roper, D.I, Fulop, V, Barreteau, H, Boniface, A, Dementin, S, Blanot, D, Mengin-Lecreulx, D, Gobec, S, Dessen, A, Dowson, C.G, Lloyd, A.J. 登録日 2013-08-09 公開日 2013-10-02 最終更新日 2021-03-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy. Nat.Chem.Biol., 2021
2J5I	Crystal Structure of Hydroxycinnamoyl-CoA Hydratase-Lyase 分子名称: P-HYDROXYCINNAMOYL COA HYDRATASE/LYASE 著者 Leonard, P.M, Brzozowski, A.M, Lebedev, A, Marshall, C.M, Smith, D.J, Verma, C.S, Walton, N.J, Grogan, G. 登録日 2006-09-18 公開日 2006-12-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The 1.8 A Resolution Structure of Hydroxycinnamoyl- Coenzyme a Hydratase-Lyase (Hchl) from Pseudomonas Fluorescens, an Enzyme that Catalyses the Transformation of Feruloyl-Coenzyme a to Vanillin. Acta Crystallogr.,Sect.D, 62, 2006
4BM2	CRYSTAL STRUCTURE OF MANGANESE PEROXIDASE 4 FROM PLEUROTUS OSTREATUS - CRYSTAL FORM II 分子名称: CALCIUM ION, MANGANESE PEROXIDASE 4, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Medrano, F.J, Romero, A. 登録日 2013-05-05 公開日 2014-01-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.391 Å) 主引用文献 Ligninolytic Peroxidase Genes in the Oyster Mushroom Genome: Heterologous Expression, Molecular Structure, Catalytic and Stability Properties, and Lignin-Degrading Ability. Biotechnol.Biofuels, 7, 2014
4BNH	Crystal structure of S. aureus FabI in complex with NADP and 5-hexyl- 2-phenoxyphenol 分子名称: 5-hexyl-2-phenoxyphenol, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], GLUTAMIC ACID, ... 著者 Schiebel, J, Chang, A, Bommineni, G.R, Tonge, P.J, Kisker, C. 登録日 2013-05-15 公開日 2013-06-05 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex. Biochemistry, 52, 2013

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