7ZPC
 
 | | CDK2 in complex 9K-DOS | | 分子名称: | Cyclin-dependent kinase 2, ~{N}-(1-methylpyrazol-4-yl)-5-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxamide | | 著者 | Watt, J.E, Martin, M.P, Noble, M.E.N. | | 登録日 | 2022-04-27 | | 公開日 | 2023-02-01 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Build-Couple-Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity.
J.Med.Chem., 65, 2022
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7UTI
 | | ALTERNATIVE MODELING OF TROPOMYOSIN IN HUMAN CARDIAC THIN FILAMENT IN THE CALCIUM BOUND STATE | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | 著者 | Rynkiewicz, M.J, Pavadai, E, Lehman, W. | | 登録日 | 2022-04-27 | | 公開日 | 2022-09-21 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Protein-Protein Docking Reveals Dynamic Interactions of Tropomyosin on Actin Filaments.
Biophys J, 119, 2020
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7UTL
 | | ALTERNATIVE MODELING OF TROPOMYOSIN IN HUMAN CARDIAC THIN FILAMENT IN THE CALCIUM FREE STATE | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | 著者 | Rynkiewicz, M.J, Pavadai, E, Lehman, W. | | 登録日 | 2022-04-27 | | 公開日 | 2022-09-21 | | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | | 主引用文献 | Protein-Protein Docking Reveals Dynamic Interactions of Tropomyosin on Actin Filaments.
Biophys J, 119, 2020
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7ZPK
 | | Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate and TARBP2 subunit | | 分子名称: | 59-nt precursor of miR-15a, Endoribonuclease Dicer, RISC-loading complex subunit TARBP2 | | 著者 | Zanova, M, Zapletal, D, Kubicek, K, Stefl, R, Pinkas, M, Novacek, J. | | 登録日 | 2022-04-27 | | 公開日 | 2022-11-16 | | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | | 主引用文献 | Structural and functional basis of mammalian microRNA biogenesis by Dicer.
Mol.Cell, 82, 2022
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7ZOS
 | | Class 1 Phytoglobin from Sugar beet (BvPgb1.2) | | 分子名称: | CYANIDE ION, HEXACYANOFERRATE(3-), Non-symbiotic hemoglobin class 1, ... | | 著者 | Nyblom, M, Christensen, S, Eriksson, N, Bulow, L. | | 登録日 | 2022-04-26 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Oxidative Implications of Substituting a Conserved Cysteine Residue in Sugar Beet Phytoglobin BvPgb 1.2.
Antioxidants, 11, 2022
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7XMS
 | | CryoEM structure of somatostatin receptor 4 (SSTR4) in complex with Gi1 and its endogeneous ligand SST-14 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Wenli, Z, Shuo, H, Na, Q, Wenbo, Z, Mengjie, L, Dehua, Y, Ming-Wei, W, Wu, B, Zhao, Q. | | 登録日 | 2022-04-26 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural insights into ligand recognition and selectivity of somatostatin receptors.
Cell Res., 32, 2022
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7XMR
 | | CryoEM structure of the somatostatin receptor 2 (SSTR2) in complex with Gi1 and its endogeneous peptide ligand SST-14 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Wenli, Z, Shuo, H, Na, Q, Wenbo, Z, Mengjie, L, Dehua, Y, Ming-Wei, W, Wu, B, Zhao, Q. | | 登録日 | 2022-04-26 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural insights into ligand recognition and selectivity of somatostatin receptors.
Cell Res., 32, 2022
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7XMT
 | | CryoEM structure of somatostatin receptor 4 (SSTR4) with Gi1 and J-2156 | | 分子名称: | (2~{S})-2-[[(2~{S})-4-azanyl-2-[(4-methylnaphthalen-1-yl)sulfonylamino]butanoyl]amino]-3-phenyl-propanimidic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Wenli, Z, Shuo, H, Na, Q, Wenbo, Z, Mengjie, L, Dehua, Y, Ming-Wei, W, Wu, B, Zhao, Q. | | 登録日 | 2022-04-26 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural insights into ligand recognition and selectivity of somatostatin receptors.
Cell Res., 32, 2022
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7XMP
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7USL
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7USM
 | | Integrin alphaM/beta2 ectodomain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Goldsmith, J.A, McLellan, J.S. | | 登録日 | 2022-04-25 | | 公開日 | 2022-08-17 | | 最終更新日 | 2022-09-14 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin.
Cell Rep, 40, 2022
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7USE
 | | Cryo-EM structure of WAVE regulatory complex with Rac1 bound on both A and D site | | 分子名称: | Abl interactor 2, Cytoplasmic FMR1-interacting protein 1, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Ding, B, Yang, S, Chen, B, Chowdhury, S. | | 登録日 | 2022-04-25 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase.
Nat Commun, 13, 2022
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7USD
 | | Cryo-EM structure of D-site Rac1-bound WAVE Regulatory Complex | | 分子名称: | Abl interactor 2, Cytoplasmic FMR1-interacting protein 1, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Ding, B, Yang, S, Chen, B, Chowdhury, S. | | 登録日 | 2022-04-25 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase.
Nat Commun, 13, 2022
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7ZOA
 | | cryo-EM structure of CGT ABC transporter in presence of CBG substrate | | 分子名称: | Beta-(1-->2)glucan export ATP-binding/permease protein NdvA, Cyclooctadecakis-(1-2)-(beta-D-glucopyranose) | | 著者 | Jaroslaw, S, Dong, C.N, Frank, L, Na, W, Renato, Z, Seunho, J, Henning, S, Christoph, D. | | 登録日 | 2022-04-24 | | 公開日 | 2022-12-07 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Mechanism of cyclic beta-glucan export by ABC transporter Cgt of Brucella.
Nat.Struct.Mol.Biol., 29, 2022
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7ZO8
 | | cryo-EM structure of CGT ABC transporter in nanodisc apo state | | 分子名称: | Beta-(1-->2)glucan export ATP-binding/permease protein NdvA, DIUNDECYL PHOSPHATIDYL CHOLINE | | 著者 | Jaroslaw, S, Dong, C.N, Frank, L, Na, W, Renato, Z, Seunho, J, Henning, S, Christoph, D. | | 登録日 | 2022-04-24 | | 公開日 | 2022-12-07 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Mechanism of cyclic beta-glucan export by ABC transporter Cgt of Brucella.
Nat.Struct.Mol.Biol., 29, 2022
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7ZO9
 | | cryo-EM structure of CGT ABC transporter in vanadate trapped state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Beta-(1-->2)glucan export ATP-binding/permease protein NdvA, VANADATE ION | | 著者 | Jaroslaw, S, Dong, C.N, Frank, L, Na, W, Renato, Z, Seunho, J, Henning, S, Christoph, D. | | 登録日 | 2022-04-24 | | 公開日 | 2022-12-07 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Mechanism of cyclic beta-glucan export by ABC transporter Cgt of Brucella.
Nat.Struct.Mol.Biol., 29, 2022
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7URO
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7ZNU
 | | cryo-EM structure of CGT ABC transporter in detergent micelle | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Beta-(1-->2)glucan export ATP-binding/permease protein NdvA, VANADATE ION | | 著者 | Jaroslaw, S, Dong, C.N, Frank, L, Na, W, Renato, Z, Seunho, J, Henning, S, Christoph, D. | | 登録日 | 2022-04-22 | | 公開日 | 2022-12-07 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Mechanism of cyclic beta-glucan export by ABC transporter Cgt of Brucella.
Nat.Struct.Mol.Biol., 29, 2022
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7XLQ
 | | Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the ligand-free (apo) state | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Gao, Y, Qiu, Y, Wei, Y, Dong, Y, Zhang, X.C, Zhao, Y. | | 登録日 | 2022-04-22 | | 公開日 | 2023-02-08 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca V 2.3.
Nat Commun, 14, 2023
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7XLP
 | | MEK1 bound to DS03090629 | | 分子名称: | (1~{R},3~{S})-3-[[6-[2-chloranyl-4-(4-methylpyrimidin-2-yl)oxy-phenyl]-3-methyl-1~{H}-indazol-4-yl]oxy]cyclohexan-1-amine, CALCIUM ION, DIMETHYL SULFOXIDE, ... | | 著者 | Kishikawa, S, Takano, K, Ubukata, O, Hanzawa, H. | | 登録日 | 2022-04-22 | | 公開日 | 2023-03-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Discovery of a Novel ATP-Competitive MEK Inhibitor DS03090629 that Overcomes Resistance Conferred by BRAF Overexpression in BRAF-Mutated Melanoma.
Mol.Cancer Ther., 22, 2023
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7XL8
 | | Human Cx36/GJD2 (N-terminal deletion mutant) gap junction channel in soybean lipids (D6 symmetry) | | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Gap junction delta-2 protein | | 著者 | Lee, S.N, Cho, H.J, Jeong, H, Ryu, B, Lee, H.J, Lee, H.H, Woo, J.S. | | 登録日 | 2022-04-21 | | 公開日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel.
Nat Commun, 14, 2023
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7ZNJ
 | | Structure of an ALYREF-exon junction complex hexamer | | 分子名称: | Eukaryotic initiation factor 4A-III, N-terminally processed, MAGNESIUM ION, ... | | 著者 | Pacheco-Fiallos, F.B, Vorlaender, M.K, Plaschka, C. | | 登録日 | 2022-04-21 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | mRNA recognition and packaging by the human transcription-export complex.
Nature, 616, 2023
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7ZNK
 | | Structure of an endogenous human TREX complex bound to mRNA | | 分子名称: | RNA, Spliceosome RNA helicase DDX39B, THO complex subunit 1, ... | | 著者 | Pacheco-Fiallos, F.B, Vorlaender, M.K, Plaschka, C. | | 登録日 | 2022-04-21 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | mRNA recognition and packaging by the human transcription-export complex.
Nature, 616, 2023
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7ZNQ
 | | ABC transporter complex NosDFYL in GDN | | 分子名称: | COPPER (II) ION, Copper-binding lipoprotein NosL, MAGNESIUM ION, ... | | 著者 | Zhang, L, Mueller, C, Zipfel, S, Chami, M, Einsle, O. | | 登録日 | 2022-04-21 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Molecular interplay of an assembly machinery for nitrous oxide reductase.
Nature, 608, 2022
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7ZNN
 | | Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and full-length rat STAT2 | | 分子名称: | B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ... | | 著者 | Lauer, S, Spahn, C.M.T, Schwefel, D. | | 登録日 | 2022-04-21 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-03-15 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor.
Embo J., 42, 2023
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