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Cryo-EM structure of D-site Rac1-bound WAVE Regulatory Complex

Summary for 7USD

Entry DOI	10.2210/pdb7usd/pdb
EMDB information	26733
Descriptor	Cytoplasmic FMR1-interacting protein 1, Nck-associated protein 1, Wiskott-Aldrich syndrome protein family member 1, ... (8 entities in total)
Functional Keywords	actin regulator, gtpase binding protein, cytoskeletal regulator, cell invasion
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	359670.25
Authors	Ding, B.,Yang, S.,Chen, B.,Chowdhury, S. (deposition date: 2022-04-25, release date: 2022-09-21, Last modification date: 2022-11-09)
Primary citation	Ding, B.,Yang, S.,Schaks, M.,Liu, Y.,Brown, A.J.,Rottner, K.,Chowdhury, S.,Chen, B. Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase. Nat Commun, 13:5444-5444, 2022 Cited by PubMed: 36114192 DOI: 10.1038/s41467-022-33174-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation