7USE

Cryo-EM structure of WAVE regulatory complex with Rac1 bound on both A and D site

Summary for 7USE

• Entry DOI: 10.2210/pdb7use/pdb
• EMDB information: 26734
• Descriptor: Cytoplasmic FMR1-interacting protein 1, GUANOSINE-5'-TRIPHOSPHATE, Nck-associated protein 1, ... (10 entities in total)
• Functional Keywords: actin regulator, gtpase binding protein, cytoskeletal regulator, cell invasion
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 7
• Total formula weight: 381242.21

Authors

Ding, B.,Yang, S.,Chen, B.,Chowdhury, S. (deposition date: 2022-04-25, release date: 2022-09-21, Last modification date: 2022-11-09)

• Primary citation: Ding, B.,Yang, S.,Schaks, M.,Liu, Y.,Brown, A.J.,Rottner, K.,Chowdhury, S.,Chen, B.; Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase.; Nat Commun, 13:5444-5444, 2022; PubMed: 36114192; DOI: 10.1038/s41467-022-33174-3

Experimental method

ELECTRON MICROSCOPY (3 Å)