PDB: 19129 件ウェブページステータス検索Chemie searchBIRD

---

4NP3	Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[(4-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroisoquinolin-8-amine, CD44 antigen, ... 著者 Liu, L.K, Finzel, B. 登録日 2013-11-20 公開日 2014-04-16 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein-Carbohydrate Interaction Inhibitors. J.Med.Chem., 57, 2014
4NQM	Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand 分子名称: 2-chloro-N-[5-(3-methyl[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-2-(morpholin-4-yl)phenyl]benzenesulfonamide, Bromodomain-containing protein 4, SUCCINIC ACID 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-11-25 公開日 2013-12-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand To be Published
4NR8	Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand 分子名称: 1,2-ETHANEDIOL, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-(2-phenylethyl)-1H-benzimidazole, Bromodomain-containing protein 4, ... 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Hay, D, Fedorov, O, Martin, S, von Delft, F, Brennan, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-11-26 公開日 2013-12-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.635 Å) 主引用文献 Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand To be Published
4OUN	Crystal Structure of Mini-ribonuclease 3 from Bacillus subtilis 分子名称: Mini-ribonuclease 3 著者 Chojnowski, G, Czarnecka, J, Nowak, E, Pianka, D, Glow, D, Sabala, I, Skowronek, K, Nowotny, M, Bujnicki, J.M. 登録日 2014-02-18 公開日 2015-02-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Sequence-specific cleavage of dsRNA by Mini-III RNase Nucleic Acids Res., 43, 2015
4OEW	Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors 分子名称: 6-ethyl-5-iodo-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one, MAGNESIUM ION, ZINC ION, ... 著者 Chen, T.T, Ren, J, Xu, Y.C. 登録日 2014-01-14 公開日 2015-04-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Thermodynamic and structural characterization of halogen bonding in protein-ligand interactions: a case study of PDE5 and its inhibitors. J.Med.Chem., 57, 2014
4OF4	X-ray structure of unliganded uridine phosphorylase from Yersinia pseudotuberculosis at 1.4 A resolution 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, SODIUM ION, ... 著者 Balaev, V.V, Lashkov, A.A, Gabdulkhakov, A.G, Betzel, C, Mikhailov, A.M. 登録日 2014-01-14 公開日 2015-02-18 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 X-ray structure of unliganded uridine phosphorylase from Yersinia pseudotuberculosis at 1.4 A resolution To be Published
4OGB	Crystal structure of the catalytic domain of PDE4D2 with compound 2 分子名称: (2R)-8-(3,4-dimethoxyphenyl)-6-methyl-2-(tetrahydro-2H-pyran-4-yl)-2H-chromen-4-ol, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Feil, S.C, Parker, M.W. 登録日 2014-01-15 公開日 2015-01-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.032 Å) 主引用文献 The PDE inhibition profile of LY294002 and tetrahydropyranyl analogues reveals a chromone motif for the development of PDE inhibitors To be Published
4MWB	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-(3-{[(2,5-dichlorothiophen-3-yl)methyl]amino}propyl)-3-thiophen-3-ylurea (Chem 1509) 分子名称: 1-(3-{[(2,5-dichlorothiophen-3-yl)methyl]amino}propyl)-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. 登録日 2013-09-24 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.313 Å) 主引用文献 Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. Plos Negl Trop Dis, 8, 2014
4MW9	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3-ethynylbenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1478) 分子名称: 1-{3-[(3-ethynylbenzyl)amino]propyl}-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. 登録日 2013-09-24 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. Plos Negl Trop Dis, 8, 2014
4MRH	Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule 分子名称: 4-chloro-5-methylbenzene-1,2-diamine, CD44 antigen, DIMETHYL SULFOXIDE 著者 Liu, L.K, Finzel, B. 登録日 2013-09-17 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein-Carbohydrate Interaction Inhibitors. J.Med.Chem., 57, 2014
4MWC	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-(3-{[(2-methyl-1-benzothiophen-3-yl)methyl]amino}propyl)-3-thiophen-3-ylurea (Chem 1540) 分子名称: 1-(3-{[(2-methyl-1-benzothiophen-3-yl)methyl]amino}propyl)-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. 登録日 2013-09-24 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.649 Å) 主引用文献 Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. Plos Negl Trop Dis, 8, 2014
4N7G	Crystal structure of 14-3-3zeta in complex with a peptide derived from ExoS 分子名称: 14-3-3 protein zeta/delta, Exoenzyme S, HEXAETHYLENE GLYCOL 著者 Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. 登録日 2013-10-15 公開日 2014-02-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
4MR6	Crystal Structure of the second bromodomain of human BRD2 in complex with a quinazolinone ligand (RVX-208) 分子名称: 1,2-ETHANEDIOL, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one, Bromodomain-containing protein 2, ... 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-09-17 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Proc.Natl.Acad.Sci.USA, 110, 2013
4MRF	Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule 分子名称: 1,2,3,4-tetrahydroisoquinoline, CD44 antigen, DIMETHYL SULFOXIDE, ... 著者 Liu, L.K, Finzel, B. 登録日 2013-09-17 公開日 2014-04-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein-Carbohydrate Interaction Inhibitors. J.Med.Chem., 57, 2014
4MWD	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1433) and ATP analog AMPPCP 分子名称: 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. 登録日 2013-09-24 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.253 Å) 主引用文献 Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. Plos Negl Trop Dis, 8, 2014
4MY4	Crystal structure of phosphoglycerate mutase from Staphylococcus aureus. 分子名称: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, MANGANESE (II) ION 著者 Roychowdhury, A, Kundu, A, Gujar, A, Bose, M, Das, A.K. 登録日 2013-09-27 公開日 2013-10-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Complete catalytic cycle of cofactor-independent phosphoglycerate mutase involves a spring-loaded mechanism Febs J., 282, 2015
4N3S	Crystal structure of eukaryotic translation initiation factor eIF5B (399-852) from Saccharomyces cerevisiae, apo form 分子名称: 1,2-ETHANEDIOL, Eukaryotic translation initiation factor 5B, GLYCEROL 著者 Kuhle, B, Ficner, R. 登録日 2013-10-07 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.832 Å) 主引用文献 eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining. Embo J., 33, 2014
4N84	Crystal structure of 14-3-3zeta in complex with a 12-carbon-linker cyclic peptide derived from ExoS 分子名称: 14-3-3 protein zeta/delta, Exoenzyme S 著者 Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. 登録日 2013-10-17 公開日 2014-02-19 最終更新日 2014-03-12 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
4MR4	Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolinone ligand (RVX-208) 分子名称: 1,2-ETHANEDIOL, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one, Bromodomain-containing protein 4 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-09-17 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Proc.Natl.Acad.Sci.USA, 110, 2013
4N3G	Crystal structure of eukaryotic translation initiation factor eIF5B (870-1116) from Chaetomium thermophilum, domains III and IV 分子名称: CHLORIDE ION, Eukaryotic translation initiation factor 5B-like protein, eIF5B(870-C), ... 著者 Kuhle, B, Ficner, R. 登録日 2013-10-07 公開日 2014-07-09 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.203 Å) 主引用文献 eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining. Embo J., 33, 2014
4MRG	Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule 分子名称: 1,2,3,4-tetrahydroisoquinolin-5-amine, CD44 antigen, DIMETHYL SULFOXIDE, ... 著者 Liu, L.K, Finzel, B. 登録日 2013-09-17 公開日 2014-04-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein-Carbohydrate Interaction Inhibitors. J.Med.Chem., 57, 2014
4NB2	Crystal Structure of FosB from Staphylococcus aureus at 1.89 Angstrom Resolution - Apo structure 分子名称: Metallothiol transferase FosB, SULFATE ION 著者 Cook, P.D, Thompson, M.K, Goodman, M.C, Jagessar, K, Harp, J, Keithly, M.E, Armstrong, R.N. 登録日 2013-10-22 公開日 2014-02-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Structure and Function of the Genomically Encoded Fosfomycin Resistance Enzyme, FosB, from Staphylococcus aureus. Biochemistry, 53, 2014
4MW4	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(5-chloro-2-hydroxy-3-iodobenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1473) 分子名称: 1-{3-[(5-chloro-2-hydroxy-3-iodobenzyl)amino]propyl}-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. 登録日 2013-09-24 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. Plos Negl Trop Dis, 8, 2014
4MVW	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1433) 分子名称: 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. 登録日 2013-09-24 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.901 Å) 主引用文献 Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. Plos Negl Trop Dis, 8, 2014
4ODG	Crystal structure of Staphylococcal nuclease variant V23I/V66I/V74I/V99I at cryogenic temperature 分子名称: CALCIUM ION, PHOSPHATE ION, THYMIDINE-3',5'-DIPHOSPHATE, ... 著者 Caro, J.A, Schlessman, J.L, Heroux, A, Garcia-Moreno E, B. 登録日 2014-01-10 公開日 2014-01-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Pressure effects in proteins To be Published

<159160161162163164165166167168169170171172173174>