PDB: 19129 件ウェブページステータス検索Chemie searchBIRD

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4MR5	Crystal Structure of the second bromodomain of human BRD2 in complex with a quinazolinone ligand (RVX-OH) 分子名称: 1,2-ETHANEDIOL, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one, Bromodomain-containing protein 2, ... 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-09-17 公開日 2013-11-27 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Proc.Natl.Acad.Sci.USA, 110, 2013
4MRD	Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule 分子名称: CD44 antigen, SULFATE ION, beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Liu, L.K, Finzel, B. 登録日 2013-09-17 公開日 2014-04-16 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein-Carbohydrate Interaction Inhibitors. J.Med.Chem., 57, 2014
4LCB	Structure of Vps4 homolog from Acidianus hospitalis 分子名称: CHLORIDE ION, Cell division protein CdvC, Vps4 著者 Han, H, Hill, C.P, Whitby, F.G, Monroe, N. 登録日 2013-06-21 公開日 2013-11-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 The Oligomeric State of the Active Vps4 AAA ATPase. J.Mol.Biol., 426, 2014
4KW9	Crystal Structure of Green Fluorescent Protein 分子名称: CHLORIDE ION, Green fluorescent protein, ZINC ION 著者 Barnard, T.J, Yu, X, Noinaj, N, Taraska, J.W. 登録日 2013-05-23 公開日 2014-04-09 最終更新日 2022-12-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structure of Green Fluorescent Protein To be Published
4L4S	Structural characterisation of the NADH binary complex of human lactate dehydrogenase M isozyme 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, L-lactate dehydrogenase A chain 著者 Dempster, S, Harper, S, Moses, J.E, Dreveny, I. 登録日 2013-06-09 公開日 2014-04-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase. Acta Crystallogr.,Sect.D, 70, 2014
4LC2	Crystal structure of the bromodomain of human BRPF1B 分子名称: 1,2-ETHANEDIOL, NITRATE ION, Peregrin 著者 Tallant, C, Nunez-Alonso, G, Savitsky, P, Picaud, S, Filippakopoulos, P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-06-21 公開日 2013-07-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of the bromodomain of human BRPF1B TO BE PUBLISHED
4L9S	Crystal Structure of H-Ras G12C, GDP-bound 分子名称: CALCIUM ION, GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-06-18 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.606 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4LCH	Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-051 complex 分子名称: (betaS)-Nalpha-{4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzoyl}-N,beta-dihydroxy-beta-methyl-L-tyrosinamide, NITRATE ION, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ... 著者 Lee, C.-J, Zhou, P. 登録日 2013-06-21 公開日 2013-08-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.596 Å) 主引用文献 Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors. J.Med.Chem., 56, 2013
4LKT	Crystal Structure of Human Epidermal Fatty Acid Binding Protein (FABP5) in Complex with Linoleic Acid 分子名称: AMMONIUM ION, CHLORIDE ION, CITRIC ACID, ... 著者 Armstrong, E.H, Ortlund, E.A. 登録日 2013-07-08 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta / delta (FABP5-PPAR beta / delta ) signaling pathway. J.Biol.Chem., 289, 2014
4L0E	Structure of P450sky (CYP163B3), a cytochrome P450 from skyllamycin biosynthesis (heme-coordinated expression tag) 分子名称: P450 monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION 著者 Cryle, M.J. 登録日 2013-05-31 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Cytochrome p450sky interacts directly with the nonribosomal Peptide synthetase to generate three amino Acid precursors in skyllamycin biosynthesis. Acs Chem.Biol., 8, 2013
4KW4	Crystal Structure of Green Fluorescent Protein 分子名称: Green fluorescent protein 著者 Barnard, T.J, Yu, X, Noinaj, N, Taraska, J.W. 登録日 2013-05-23 公開日 2014-04-09 最終更新日 2022-12-21 実験手法 X-RAY DIFFRACTION (1.746 Å) 主引用文献 Crystal Structure of Green Fluorescent Protein To be Published
4NP2	Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[(4-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroisoquinoline, CD44 antigen, ... 著者 Liu, L.K, Finzel, B. 登録日 2013-11-20 公開日 2014-04-16 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein-Carbohydrate Interaction Inhibitors. J.Med.Chem., 57, 2014
4NNI	Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide 分子名称: 30S ribosomal protein S1, PYRAZINE-2-CARBOXYLIC ACID 著者 Yang, J, Liu, Y, Cai, Q, Lin, D. 登録日 2013-11-18 公開日 2014-12-24 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide. Mol.Microbiol., 95, 2015
4MEQ	Crystal Structure of the first bromodomain of human BRD4 in complex with a 5-methyl-triazolopyrimidine ligand 分子名称: 1,2-ETHANEDIOL, 5-methyl-7-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-2-amine, Bromodomain-containing protein 4 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Fedorov, O, Vidler, L.R, Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Hoelder, S, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-08-27 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening. J.Med.Chem., 56, 2013
4LAA	Crystal structure of Staphylococcal nuclease variant Delta+PHS L36H at cryogenic temperature 分子名称: CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease 著者 Wheeler, E.L, Schlessman, J.L, Heroux, A, Garcia-Moreno E, B, Robinson, A.C. 登録日 2013-06-19 公開日 2013-08-21 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Crystal structure of Staphylococcal nuclease variant Delta+PHS L36H at cryogenic temperature To be Published
4N7Y	Crystal structure of 14-3-3zeta in complex with a 8-carbon-linker cyclic peptide derived from ExoS 分子名称: 14-3-3 protein zeta/delta, Exoenzyme S 著者 Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. 登録日 2013-10-16 公開日 2014-02-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
4N3N	Crystal structure of eukaryotic translation initiation factor eIF5B (517-1116) from Chaetomium thermophilum, apo form 分子名称: Eukaryotic translation initiation factor 5B-like protein, eIF5B(517-C), LACTIC ACID 著者 Kuhle, B, Ficner, R. 登録日 2013-10-07 公開日 2014-07-09 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.752 Å) 主引用文献 eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining. Embo J., 33, 2014
4NCN	Crystal structure of eukaryotic translation initiation factor eIF5B (517-858) from Chaetomium thermophilum in complex with GTP 分子名称: ACETIC ACID, Eukaryotic translation initiation factor 5B-like protein, GLYCEROL, ... 著者 Kuhle, B, Ficner, R. 登録日 2013-10-24 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining. Embo J., 33, 2014
4NCL	Crystal structure of eukaryotic translation initiation factor eIF5B (517-970) from Chaetomium thermophilum in complex with GDP 分子名称: Eukaryotic translation initiation factor 5B-like protein, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Kuhle, B, Ficner, R. 登録日 2013-10-24 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.115 Å) 主引用文献 eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining. Embo J., 33, 2014
4NKL	Crystal structure of Staphylococcal nuclease variant Delta+PHS V66A/I92Q at cryogenic temperature 分子名称: CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease 著者 Caro, J.A, Sorenson, J.L, Schlessman, J.L, Heroux, A, Garcia-Moreno E, B. 登録日 2013-11-12 公開日 2013-11-20 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Pressure effects in proteins To be Published
4NIO	GVTGIAQ segment 147-153 from Human Superoxide Dismutase with I149T mutation associated with a familial form of amyotrophic lateral sclerosis 分子名称: GVTGIAQ segment from Superoxide dismutase [Cu-Zn] 著者 Sievers, S.A, Sawaya, M.R, Eisenberg, D, Ivanova, M.I. 登録日 2013-11-06 公開日 2013-12-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS. Proc.Natl.Acad.Sci.USA, 111, 2014
4NMZ	Crystal structure of Staphylococcal nuclease variant Delta+PHS V23Q/V66A at cryogenic temperature 分子名称: CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease 著者 Caro, J.A, Sorenson, J.L, Schlessman, J.L, Heroux, A, Garcia-Moreno E, B. 登録日 2013-11-15 公開日 2013-12-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Cavities in proteins To be Published
4NQN	Crystal Structure of the bromodomain of human BRD9 in complex with a triazolo-phthalazine ligand 分子名称: 2-chloro-N-[5-(3-methyl[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-2-(morpholin-4-yl)phenyl]benzenesulfonamide, Bromodomain-containing protein 9 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-11-25 公開日 2013-12-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Crystal Structure of the bromodomain of human BRD9 in complex with a triazolo-phthalazine ligand To be Published
4MEO	Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-methyl-quinoline ligand 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, DIMETHYL SULFOXIDE, ... 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Fedorov, O, Vidler, L.R, Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Hoelder, S, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-08-27 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening. J.Med.Chem., 56, 2013
4MEP	Crystal Structure of the first bromodomain of human BRD4 in complex with a 3-chloro-pyridone ligand 分子名称: 3-chloro-5-[1-(3-methylpyridin-2-yl)-3-phenyl-1H-1,2,4-triazol-5-yl]pyridin-2(1H)-one, Bromodomain-containing protein 4 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Fedorov, O, Vidler, L.R, Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Hoelder, S, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-08-27 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening. J.Med.Chem., 56, 2013

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