PDB: 5495 件ウェブページステータス検索Chemie searchBIRD

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7UG5	Second bromodomain of BRD3 liganded with BMS-536924 分子名称: (3M)-4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 3 著者 Schonbrunn, E, Bikowitz, M. 登録日 2022-03-23 公開日 2023-04-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis of CBP and EP300 interaction with kinase inhibitors To Be Published
6E4A	Crystal structure of human BRD4(1) in complex with CN750 分子名称: 5-(4-{[(3-chlorophenyl)methyl]amino}-2-{4-[2-(dimethylamino)ethyl]piperazin-1-yl}quinazolin-6-yl)-1-methylpyridin-2(1H)-one, Bromodomain-containing protein 4, GLYCEROL 著者 Fontano, E, White, A, Lakshminarasimhan, D, Suto, R.K. 登録日 2018-07-17 公開日 2018-09-12 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Discovery and lead identification of quinazoline-based BRD4 inhibitors. Bioorg. Med. Chem. Lett., 28, 2018
6E1Z	Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity 分子名称: 5-[(1H-imidazol-1-yl)methyl]furan-2-carboxylic acid, WD repeat-containing protein 5 著者 Phan, J, Fesik, S.W. 登録日 2018-07-10 公開日 2019-03-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep, 26, 2019
5Z5U	The first bromodomain of BRD4 with compound BDF-2254 分子名称: 2-amino-4-(1H-imidazol-1-yl)quinoline-6,8-diol, Bromodomain-containing protein 4 著者 Zhang, H, Luo, C. 登録日 2018-01-20 公開日 2019-01-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.631 Å) 主引用文献 Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma. Oncogenesis, 7, 2018
7XI9	Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-ordered form) 分子名称: DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*TP*CP*(C55)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... 著者 Onoda, H, Kikuchi, A, Kori, S, Yoshimi, S, Yamagata, A, Arita, K. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (2.52 Å) 主引用文献 Structural basis for activation of DNMT1. Nat Commun, 13, 2022
7XIB	Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-disordered form) 分子名称: DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*TP*CP*(C55)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... 著者 Onoda, H, Kikuchi, A, Kori, S, Yoshimi, S, Yamagata, A, Arita, K. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (2.23 Å) 主引用文献 Structural basis for activation of DNMT1. Nat Commun, 13, 2022
6E2H	Crystal structure of human Ash2L (SPRY domain and SDI motif) in complex with full length DPY-30 分子名称: Protein dpy-30 homolog, Set1/Ash2 histone methyltransferase complex subunit ASH2 著者 Joshi, M, Brunzelle, J.S, Couture, J.F. 登録日 2018-07-11 公開日 2018-08-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.236 Å) 主引用文献 Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation. Structure, 26, 2018
5ZCJ	Crystal structure of complex 分子名称: TP53-binding protein 1, Tudor-interacting repair regulator protein 著者 Wang, J, Yuan, Z, Cui, Y, Xie, R, Wang, M, Ma, Y, Yu, X, Liu, X. 登録日 2018-02-17 公開日 2018-06-27 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.004 Å) 主引用文献 Crystal structure of complex To Be Published
6E23	Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-[(3,4-dichlorophenyl)methyl]-3-(6-fluoro-2-methylpyridin-3-yl)-5-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}benzamide, WD repeat-containing protein 5 著者 Phan, J, Fesik, S.W. 登録日 2018-07-10 公開日 2019-03-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep, 26, 2019
8AEL	SYNJ2BP complex with a synthetic Vangl2 peptide (3mer). 分子名称: CALCIUM ION, GLY-GLY-GLY-THR-SER-VAL, GLYCEROL, ... 著者 Carrasco, K, Cousido Siah, A, Gogl, G, Betzi, S, McEwen, A, Kostmann, C, Trave, G. 登録日 2022-07-13 公開日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 SYNJ2BP PDZ domain in complex with a synthetic Vangl2 peptide. To Be Published
6E22	Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity 分子名称: 3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}-N-[(3,5-dimethoxyphenyl)methyl]-4-fluorobenzamide, SULFATE ION, WD repeat-containing protein 5 著者 Phan, J, Fesik, S.W. 登録日 2018-07-10 公開日 2019-03-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep, 26, 2019
5YVG	Crystal structure of Karyopherin beta2 in complex with FUS(full length) 分子名称: RNA-binding protein FUS, Transportin-1 著者 Yoshizawa, T, Fung, H.Y.J, Chook, Y.M. 登録日 2017-11-25 公開日 2018-05-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (4.05 Å) 主引用文献 Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites. Cell, 173, 2018
7LMZ	Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 1) 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Hexa-ubiquitin, ... 著者 Pan, M, Yu, Y, Liu, L, Zhao, M. 登録日 2021-02-06 公開日 2021-09-15 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.06 Å) 主引用文献 Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
7LN4	Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (FOM, Class 3) 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Pan, M, Yu, Y, Liu, L, Zhao, M. 登録日 2021-02-06 公開日 2021-09-15 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
7LMY	Cryo-EM structure of human p97 in complex with NMS-873 in the presence of ATP, Npl4/Ufd1, and Ub6 分子名称: 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Pan, M, Yu, Y, Liu, L, Zhao, M. 登録日 2021-02-06 公開日 2021-09-15 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
7LN2	Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (FOM, Class 1) 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Pan, M, Yu, Y, Liu, L, Zhao, M. 登録日 2021-02-06 公開日 2021-09-15 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.63 Å) 主引用文献 Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
7LN0	Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 2) 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Hexa-ubiquitin, ... 著者 Pan, M, Yu, Y, Liu, L, Zhao, M. 登録日 2021-02-06 公開日 2021-09-15 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (2.98 Å) 主引用文献 Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
7LN6	Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (CHAPSO, Class 2, Open State) 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Pan, M, Yu, Y, Liu, L, Zhao, M. 登録日 2021-02-06 公開日 2021-09-15 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.58 Å) 主引用文献 Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
5Z1S	Crystal Structure Analysis of the BRD4(1) 分子名称: 1,2-ETHANEDIOL, 5-bromo-2-methoxy-N-(6-methoxy-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)benzene-1-sulfonamide, Bromodomain-containing protein 4, ... 著者 Xu, Y, Zhang, Y, Xiang, Q, Song, M, Wang, C. 登録日 2017-12-28 公開日 2019-01-02 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Y08060: A Selective BET Inhibitor for Treatment of Prostate Cancer. Acs Med.Chem.Lett., 9, 2018
7LN5	Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (CHAPSO, Class 1, Close State) 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Pan, M, Yu, Y, Liu, L, Zhao, M. 登録日 2021-02-06 公開日 2021-09-15 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
7LN1	Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 3) 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Hexa-ubiquitin, ... 著者 Pan, M, Yu, Y, Liu, L, Zhao, M. 登録日 2021-02-06 公開日 2021-09-15 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
7LN3	Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (FOM, Class 2) 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Pan, M, Yu, Y, Liu, L, Zhao, M. 登録日 2021-02-06 公開日 2021-09-15 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.45 Å) 主引用文献 Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
5Z78	Structure of TIRR/53BP1 complex 分子名称: TP53-binding protein 1, Tudor-interacting repair regulator protein 著者 Dai, Y.X, Shan, S. 登録日 2018-01-27 公開日 2018-06-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.762 Å) 主引用文献 Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR Nat Commun, 9, 2018
7M16	Triazole-based BET family bromodomain inhibitor bound to BRD4(D1) 分子名称: 4-{5-[6-(3,5-dimethylanilino)pyridin-2-yl]-4-methyl-1H-1,2,3-triazol-1-yl}piperidine-1-carboximidamide, Bromodomain-containing protein 4 著者 Johnson, J.A, Pomerantz, W. 登録日 2021-03-12 公開日 2021-09-29 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Systematically Mitigating the p38alpha Activity of Triazole-based BET Inhibitors ACS Med. Chem. Lett., 10, 2019
2HDE	Solution Structure of Human SAP18 分子名称: Histone deacetylase complex subunit SAP18 著者 McCallum, S.A, Yin, J.P, Pan, B, Fairbrother, W.J. 登録日 2006-06-20 公開日 2007-04-24 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly. Biochemistry, 45, 2006

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