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6E4A

Crystal structure of human BRD4(1) in complex with CN750

Summary for 6E4A
Entry DOI10.2210/pdb6e4a/pdb
DescriptorBromodomain-containing protein 4, 5-(4-{[(3-chlorophenyl)methyl]amino}-2-{4-[2-(dimethylamino)ethyl]piperazin-1-yl}quinazolin-6-yl)-1-methylpyridin-2(1H)-one, GLYCEROL, ... (4 entities in total)
Functional Keywordsbrd4(bd1), protein binding
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight31999.64
Authors
Fontano, E.,White, A.,Lakshminarasimhan, D.,Suto, R.K. (deposition date: 2018-07-17, release date: 2018-09-12, Last modification date: 2024-03-13)
Primary citationYang, S.M.,Urban, D.J.,Yoshioka, M.,Strovel, J.W.,Fletcher, S.,Wang, A.Q.,Xu, X.,Shah, P.,Hu, X.,Hall, M.D.,Jadhav, A.,Maloney, D.J.
Discovery and lead identification of quinazoline-based BRD4 inhibitors.
Bioorg. Med. Chem. Lett., 28:3483-3488, 2018
Cited by
PubMed: 30268702
DOI: 10.1016/j.bmcl.2018.08.039
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.26 Å)
Structure validation

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