6E4A
Crystal structure of human BRD4(1) in complex with CN750
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Bromodomain-containing protein 4 | polymer | 129 | 15329.6 | 2 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (Human) | Protein HUNK1 |
| 2 | A, B | 5-(4-{[(3-chlorophenyl)methyl]amino}-2-{4-[2-(dimethylamino)ethyl]piperazin-1-yl}quinazolin-6-yl)-1-methylpyridin-2(1H)-one | non-polymer | 532.1 | 2 | Chemie (HRY) | |||
| 3 | A, B | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | water | water | 18.0 | 450 | Chemie (HOH) |
Sequence modifications
A, B: 44 - 170 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ser 42 | - | expression tag |
| Met 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30659.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1340.4 | |
| All* | Total formula weight | 31999.6 |
