5UDQ
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![BU of 5udq by Molmil](/molmil-images/mine/5udq) | LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, apo form | 分子名称: | Lactate racemization operon protein LarE, PHOSPHATE ION, SULFATE ION | 著者 | Fellner, M, Desguin, B, Hausinger, R.P, Hu, J. | 登録日 | 2016-12-28 | 公開日 | 2017-08-23 | 最終更新日 | 2019-11-27 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7ZJZ
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![BU of 7zjz by Molmil](/molmil-images/mine/7zjz) | catalytically non active S532A mutant of oligopeptidase B from S. proteomaculans | 分子名称: | Oligopeptidase B, SPERMINE | 著者 | Petrenko, D.E, Boyko, K.M, Nikolaeva, A.Y, Vlaskina, A.V, Mikhailova, A.G, Timofeev, V.I, Rakitina, T.V. | 登録日 | 2022-04-12 | 公開日 | 2023-01-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Elucidation of the Conformational Transition of Oligopeptidase B by an Integrative Approach Based on the Combination of X-ray, SAXS, and Essential Dynamics Sampling Simulation Crystals, 12, 2022
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6UOE
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5UDU
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![BU of 5udu by Molmil](/molmil-images/mine/5udu) | LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, in complex with manganese | 分子名称: | Lactate racemization operon protein LarE, MANGANESE (II) ION, PHOSPHATE ION, ... | 著者 | Fellner, M, Desguin, B, Hausinger, R.P, Hu, J. | 登録日 | 2016-12-28 | 公開日 | 2017-08-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.792 Å) | 主引用文献 | Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6J8R
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3NUB
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![BU of 3nub by Molmil](/molmil-images/mine/3nub) | WbpE, an Aminotransferase from Pseudomonas aeruginosa Involved in O-antigen Assembly in Complex with Product as the External Aldimine | 分子名称: | (2S,3S,4R,5R,6R)-5-(acetylamino)-6-{[(S)-{[(S)-{[(2S,3R,4S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-3-hydroxy-4-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}tetrahydro-2H-pyran-2-carboxylic acid, Aminotransferase WbpE, GLYCEROL, ... | 著者 | Larkin, A, Olivier, N.B, Imperiali, B. | 登録日 | 2010-07-06 | 公開日 | 2010-07-28 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Analysis of WbpE from Pseudomonas aeruginosa PAO1: A Nucleotide Sugar Aminotransferase Involved in O-Antigen Assembly Biochemistry, 49, 2010
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6B2Q
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![BU of 6b2q by Molmil](/molmil-images/mine/6b2q) | Dual Inhibition of the Essential Protein Kinases A and B in Mycobacterium tuberculosis | 分子名称: | 3-methyl-1-(2-methylpropyl)butyl 4-O-beta-L-gulopyranosyl-beta-D-glucopyranoside, 5-{5-chloro-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}thiophene-2-sulfonamide, Serine/threonine-protein kinase PknA | 著者 | Zuccola, H.J. | 登録日 | 2017-09-20 | 公開日 | 2018-02-14 | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | 主引用文献 | Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions. ACS Med Chem Lett, 8, 2017
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7SZQ
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![BU of 7szq by Molmil](/molmil-images/mine/7szq) | Human P300 complexed with an azaindazole inhibitor | 分子名称: | 1-[1-(4-chlorophenyl)cyclopentane-1-carbonyl]-N-1H-pyrazolo[4,3-b]pyridin-5-yl-D-prolinamide, Histone acetyltransferase p300 | 著者 | Shewchuk, L.M, Reid, R.A. | 登録日 | 2021-11-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening. J.Med.Chem., 65, 2022
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7WSB
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![BU of 7wsb by Molmil](/molmil-images/mine/7wsb) | The ternary complex structure of FtmOx1 with a-ketoglutarate and 13-oxo-fumitremorgin B | 分子名称: | 13-Oxofumitremorgin B, 2-OXOGLUTARIC ACID, COBALT (II) ION, ... | 著者 | Wang, J, Wang, X.Y, Wang, Y.Y, Yan, W.P. | 登録日 | 2022-01-28 | 公開日 | 2022-07-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues. Jacs Au, 2, 2022
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4R49
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![BU of 4r49 by Molmil](/molmil-images/mine/4r49) | Racemic crystal structure of a calcium-bound B-DNA duplex | 分子名称: | 5'-D(*CP*CP*GP*GP*TP*AP*CP*CP*GP*G)-3', CALCIUM ION, SODIUM ION | 著者 | Mandal, P.K, Collie, G.W, Kauffmann, B, Huc, I. | 登録日 | 2014-08-19 | 公開日 | 2014-11-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Racemic DNA crystallography. Angew.Chem.Int.Ed.Engl., 53, 2014
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7TD9
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![BU of 7td9 by Molmil](/molmil-images/mine/7td9) | G-059 bound to the SMARCA4 (BRG1) Bromodomain | 分子名称: | 4-phenyl-5H-pyridazino[4,3-b]indol-3-amine, Isoform 4 of Transcription activator BRG1 | 著者 | Tang, Y, Poy, F, Taylor, A.M, Cochran, A.G, Bellon, S.F. | 登録日 | 2021-12-30 | 公開日 | 2022-08-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1. J.Med.Chem., 65, 2022
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2P3A
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![BU of 2p3a by Molmil](/molmil-images/mine/2p3a) | Crystal Structure of the multi-drug resistant mutant subtype B HIV protease complexed with TL-3 inhibitor | 分子名称: | benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate, protease | 著者 | Sanches, M, Krauchenco, S, Martins, N.H, Gustchina, A, Wlodawer, A, Polikarpov, I. | 登録日 | 2007-03-08 | 公開日 | 2007-04-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development. J.Mol.Biol., 369, 2007
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6FCZ
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![BU of 6fcz by Molmil](/molmil-images/mine/6fcz) | Model of gC1q-Fc complex based on 7A EM map | 分子名称: | Complement C1q subcomponent subunit A, Complement C1q subcomponent subunit B, Complement C1q subcomponent subunit C, ... | 著者 | Ugurlar, D, Howes, S.C, de Kreuk, B.J.K, de Jong, R.N, Beurskens, F.J, Koster, A.J, Parren, P.W.H.I, Sharp, T.H, Gros, P, Koning, R.I. | 登録日 | 2017-12-21 | 公開日 | 2018-02-28 | 最終更新日 | 2018-10-24 | 実験手法 | ELECTRON MICROSCOPY (10 Å) | 主引用文献 | Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement. Science, 359, 2018
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1O6I
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![BU of 1o6i by Molmil](/molmil-images/mine/1o6i) | Chitinase B from Serratia marcescens complexed with the catalytic intermediate mimic cyclic dipeptide CI4. | 分子名称: | Chitinase, GLYCEROL, SULFATE ION, ... | 著者 | Houston, D.R, Eggleston, I, Synstad, B, Eijsink, V.G.H, van Aalten, D.M.F. | 登録日 | 2002-10-03 | 公開日 | 2003-03-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The cyclic dipeptide CI-4 [cyclo-(l-Arg-d-Pro)] inhibits family 18 chitinases by structural mimicry of a reaction intermediate. Biochem. J., 368, 2002
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1KJ2
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![BU of 1kj2 by Molmil](/molmil-images/mine/1kj2) | Murine Alloreactive ScFv TCR-Peptide-MHC Class I Molecule Complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Allogeneic H-2Kb MHC Class I Molecule, Beta-2 microglobulin, ... | 著者 | Reiser, J.-B, Gregoire, C, Darnault, C, Mosser, T, Guimezanes, A, Schmitt-Verhulst, A.-M, Fontecilla-Camps, J.C, Mazza, G, Malissen, B, Housset, D. | 登録日 | 2001-12-04 | 公開日 | 2002-03-27 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex. Immunity, 16, 2002
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7K7H
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![BU of 7k7h by Molmil](/molmil-images/mine/7k7h) | Density-fitted Model Structure of Antibody Variable Domains of TyTx1 in Complex with PltB pentamer of Typhoid Toxin | 分子名称: | Fab Heavy Chain Variable Domain, Fab Light Chain Variable Domain, Pertussis like toxin subunit B, ... | 著者 | Nguyen, T, Feathers, J.R, Fromme, J.C, Song, J. | 登録日 | 2020-09-22 | 公開日 | 2021-09-01 | 最終更新日 | 2021-09-22 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | The structural basis of Salmonella A 2 B 5 toxin neutralization by antibodies targeting the glycan-receptor binding subunits. Cell Rep, 36, 2021
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5SZM
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![BU of 5szm by Molmil](/molmil-images/mine/5szm) | Protocadherin gamma A8 extracellular cadherin domains 1-4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, PcdhgA8 or protocadherin gamma A8, ... | 著者 | Goodman, K.M, Mannepalli, S, Bahna, F, Honig, B, Shapiro, L. | 登録日 | 2016-08-14 | 公開日 | 2016-10-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | gamma-Protocadherin structural diversity and functional implications. Elife, 5, 2016
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5J1Q
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7O5E
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4E6D
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![BU of 4e6d by Molmil](/molmil-images/mine/4e6d) | JAK2 kinase (JH1 domain) triple mutant in complex with compound 7 | 分子名称: | 3-[(3R)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)piperidin-1-yl]-3-oxopropanenitrile, GLYCEROL, Tyrosine-protein kinase JAK2 | 著者 | Murray, J.M. | 登録日 | 2012-03-15 | 公開日 | 2012-05-30 | 最終更新日 | 2023-03-01 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors. J.Med.Chem., 55, 2012
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7K63
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6MLK
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![BU of 6mlk by Molmil](/molmil-images/mine/6mlk) | Structure of Thioesterase from DEBS with a thioesterase-specific antibody | 分子名称: | 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6, CHLORIDE ION, ... | 著者 | Mathews, I.I, Li, X, Khosla, C. | 登録日 | 2018-09-27 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase. Biochemistry, 57, 2018
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7K61
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5A7C
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![BU of 5a7c by Molmil](/molmil-images/mine/5a7c) | Crystal structure of the second bromodomain of human BRD3 in complex with compound | 分子名称: | 1,2-ETHANEDIOL, BROMODOMAIN-CONTAINING PROTEIN 3, N-(6-ACETAMIDOHEXYL)ACETAMIDE | 著者 | Welin, M, Kimbung, R, Diehl, C, Hakansson, M, Logan, D.T, Walse, B. | 登録日 | 2015-07-03 | 公開日 | 2016-03-16 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Cancer Differentiating Agent Hexamethylene Bisacetamide Inhibits Bet Bromodomain Proteins. Cancer Res., 76, 2016
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4BQ5
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![BU of 4bq5 by Molmil](/molmil-images/mine/4bq5) | Structural analysis of an exo-beta-agarase | 分子名称: | 3,6-anhydro-alpha-L-galactopyranose, 3,6-anhydro-alpha-L-galactopyranose-(1-3)-beta-D-galactopyranose, 3,6-anhydro-alpha-L-galactopyranose-(1-3)-beta-D-galactopyranose-(1-4)-3,6-anhydro-alpha-L-galactopyranose-(1-3)-beta-D-galactopyranose, ... | 著者 | Pluvinage, B, Hehemann, J.H, Boraston, A.B. | 登録日 | 2013-05-29 | 公開日 | 2013-08-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Substrate Recognition and Hydrolysis by a Family 50 Exo-Beta-Agarase Aga50D from the Marine Bacterium Saccharophagus Degradans J.Biol.Chem., 288, 2013
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