4E6D
JAK2 kinase (JH1 domain) triple mutant in complex with compound 7
Summary for 4E6D
Entry DOI | 10.2210/pdb4e6d/pdb |
Related | 4E4L 4E4M 4E4N 4E5W 4E6Q |
Descriptor | Tyrosine-protein kinase JAK2, 3-[(3R)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)piperidin-1-yl]-3-oxopropanenitrile, GLYCEROL, ... (4 entities in total) |
Functional Keywords | jak2, kinase, transferase, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Endomembrane system; Peripheral membrane protein (By similarity): O60674 |
Total number of polymer chains | 2 |
Total formula weight | 71158.94 |
Authors | Murray, J.M. (deposition date: 2012-03-15, release date: 2012-05-30, Last modification date: 2023-03-01) |
Primary citation | Kulagowski, J.J.,Blair, W.,Bull, R.J.,Chang, C.,Deshmukh, G.,Dyke, H.J.,Eigenbrot, C.,Ghilardi, N.,Gibbons, P.,Harrison, T.K.,Hewitt, P.R.,Liimatta, M.,Hurley, C.A.,Johnson, A.,Johnson, T.,Kenny, J.R.,Bir Kohli, P.,Maxey, R.J.,Mendonca, R.,Mortara, K.,Murray, J.,Narukulla, R.,Shia, S.,Steffek, M.,Ubhayakar, S.,Ultsch, M.,van Abbema, A.,Ward, S.I.,Waszkowycz, B.,Zak, M. Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors. J.Med.Chem., 55:5901-5921, 2012 Cited by PubMed: 22591402DOI: 10.1021/jm300438j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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