4E6D
JAK2 kinase (JH1 domain) triple mutant in complex with compound 7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase JAK2 | polymer | 298 | 35225.1 | 2 | UniProt (O60674) Pfam (PF07714) | Homo sapiens (human) | Janus kinase 2, JAK-2 |
| 2 | C, D (A, B) | 3-[(3R)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)piperidin-1-yl]-3-oxopropanenitrile | non-polymer | 308.3 | 2 | Chemie (0NU) | |||
| 3 | E (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 308 | Chemie (HOH) |
Sequence modifications
A, B: 835 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Arg 853 | Gln 853 | engineered mutation |
| Phe 931 | Tyr 931 | engineered mutation |
| Glu 939 | Asp 939 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70450.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 708.8 | |
| All* | Total formula weight | 71158.9 |
