7SZQ

Human P300 complexed with an azaindazole inhibitor

Summary for 7SZQ

Entry DOI	10.2210/pdb7szq/pdb
Descriptor	Histone acetyltransferase p300, 1-[1-(4-chlorophenyl)cyclopentane-1-carbonyl]-N-1H-pyrazolo[4,3-b]pyridin-5-yl-D-prolinamide (3 entities in total)
Functional Keywords	histone acetyltransferase, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	45447.07
Authors	Shewchuk, L.M.,Reid, R.A. (deposition date: 2021-11-29, release date: 2022-11-09, Last modification date: 2023-10-18)
Primary citation	Tian, X.,Suarez, D.,Thomson, D.,Li, W.,King, E.A.,LaFrance, L.,Boehm, J.,Barton, L.,Di Marco, C.,Martyr, C.,Thalji, R.,Medina, J.,Knight, S.,Heerding, D.,Gao, E.,Nartey, E.,Cecconie, T.,Nixon, C.,Zhang, G.,Berrodin, T.J.,Phelps, C.,Patel, A.,Bai, X.,Lind, K.,Prabhu, N.,Messer, J.,Zhu, Z.,Shewchuk, L.,Reid, R.,Graves, A.P.,McHugh, C.,Mangatt, B. Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening. J.Med.Chem., 65:14391-14408, 2022 Cited by PubMed: 36302181 DOI: 10.1021/acs.jmedchem.2c00670 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation