7SZQ
Human P300 complexed with an azaindazole inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Histone acetyltransferase p300 | polymer | 389 | 45009.2 | 1 | UniProt (Q09472) Pfam (PF08214) In PDB | Homo sapiens (human) | p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein 2-hydroxyisobutyryltransferase p300,Protein lactyltransferas p300,Protein propionyltransferase p300 |
2 | A | 1-[1-(4-chlorophenyl)cyclopentane-1-carbonyl]-N-1H-pyrazolo[4,3-b]pyridin-5-yl-D-prolinamide | non-polymer | 437.9 | 1 | Chemie (ETL) | |||
3 | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
A: 1279 - 1666 (UniProt: Q09472)
PDB | External Database | Details |
---|---|---|
Gly 1278 | - | expression tag |
Phe 1467 | Tyr 1467 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 45009.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 437.9 | |
All* | Total formula weight | 45447.1 |