7NHA
 
 | | 1918 H1N1 Viral influenza polymerase heterotrimer - Endonuclease and priming loop ordered (Class2a) | | 分子名称: | Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3'), ... | | 著者 | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | | 登録日 | 2021-02-10 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
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7NIK
 | | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8189 core | | 分子名称: | Nanobody8189 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... | | 著者 | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | | 登録日 | 2021-02-12 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | | 主引用文献 | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
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7NKC
 | | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8207 | | 分子名称: | Nb8207, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... | | 著者 | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | | 登録日 | 2021-02-17 | | 公開日 | 2021-12-01 | | 最終更新日 | 2022-02-09 | | 実験手法 | ELECTRON MICROSCOPY (4.46 Å) | | 主引用文献 | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
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7NJ4
 | | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8198 core | | 分子名称: | Nb8198 Core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... | | 著者 | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | | 登録日 | 2021-02-16 | | 公開日 | 2021-12-01 | | 最終更新日 | 2022-02-09 | | 実験手法 | ELECTRON MICROSCOPY (5.84 Å) | | 主引用文献 | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
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7NK4
 | | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8203 core | | 分子名称: | Nanobody 8203, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... | | 著者 | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | | 登録日 | 2021-02-17 | | 公開日 | 2021-12-01 | | 最終更新日 | 2022-02-09 | | 実験手法 | ELECTRON MICROSCOPY (5.32 Å) | | 主引用文献 | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
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7NHC
 | | 1918 H1N1 Viral influenza polymerase heterotrimer - Endonuclease ordered (Class2b) | | 分子名称: | Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3'), ... | | 著者 | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | | 登録日 | 2021-02-10 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | | 主引用文献 | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
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7NIL
 | | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8190 core | | 分子名称: | Nanobody8190 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... | | 著者 | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | | 登録日 | 2021-02-12 | | 公開日 | 2021-12-01 | | 最終更新日 | 2022-02-09 | | 実験手法 | ELECTRON MICROSCOPY (5.01 Å) | | 主引用文献 | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
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7NK8
 | | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8205 core | | 分子名称: | Nb8205, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... | | 著者 | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | | 登録日 | 2021-02-17 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (5.34 Å) | | 主引用文献 | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
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8C4V
 | | Hantaan virus polymerase in replication elongation state | | 分子名称: | MAGNESIUM ION, RNA (5'-R(P*AP*CP*UP*AP*CP*UP*A)-3'), RNA (5'-R(P*AP*GP*GP*AP*GP*UP*AP*UP*CP*CP*AP*CP*CP*GP*CP*AP*AP*GP*A)-3'), ... | | 著者 | Durieux trouilleton, Q, Arragain, B, Malet, H. | | 登録日 | 2023-01-04 | | 公開日 | 2023-06-07 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | | 主引用文献 | Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication.
Nat Commun, 14, 2023
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8C4U
 | | Hantaan virus polymerase in replication pre-initiation state | | 分子名称: | MAGNESIUM ION, RNA (5'-R(P*UP*AP*GP*GP*AP*GP*UP*AP*UP*CP*CP*AP*CP*CP*GP*CP*AP*AP*GP*A)-3'), RNA (5'-R(P*UP*UP*UP*UP*GP*CP*GP*GP*AP*GP*UP*AP*CP*UP*AP*CP*UP*A)-3'), ... | | 著者 | Durieux trouilleton, Q, Arragain, B, Malet, H. | | 登録日 | 2023-01-04 | | 公開日 | 2023-06-07 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication.
Nat Commun, 14, 2023
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7OMA
 | | Thosea asigna virus RdRP domain elongation complex | | 分子名称: | MAGNESIUM ION, PYROPHOSPHATE 2-, RNA (5'-R(P*AP*AP*AP*UP*UP*UP*U)-3'), ... | | 著者 | Ferrero, D.S, Falqui, M, Verdaguer, N. | | 登録日 | 2021-05-21 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Snapshots of a Non-Canonical RdRP in Action.
Viruses, 13, 2021
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3GYN
 | | Crystal structure of HCV NS5B polymerase with a novel monocyclic dihydropyridinone inhibitor | | 分子名称: | N-{3-[(5R)-1-cyclopentyl-4-hydroxy-5-methyl-5-(3-methylbutyl)-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase | | 著者 | Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. | | 登録日 | 2009-04-04 | | 公開日 | 2009-12-08 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | 5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg.Med.Chem.Lett., 19, 2009
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7OM6
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7OM7
 | | Thosea asigna virus RdRP domain in complex with RNA and nucleotide UMPNPP | | 分子名称: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ... | | 著者 | Ferrero, D.S, Falqui, M, Verdaguer, N. | | 登録日 | 2021-05-21 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Snapshots of a Non-Canonical RdRP in Action.
Viruses, 13, 2021
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2ZTT
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3IGV
 | | Crystal structure of HCV NS5B polymerase with a novel monocyclic dihydro-pyridinone inhibitor | | 分子名称: | N-{3-[(6S)-6-ethyl-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-DIRECTED RNA POLYMERASE | | 著者 | Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. | | 登録日 | 2009-07-28 | | 公開日 | 2009-12-08 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | 5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg.Med.Chem.Lett., 19, 2009
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8C4T
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7OM2
 | | Thosea asigna virus RdRP domain in complex with Mg+2 | | 分子名称: | GLYCEROL, MAGNESIUM ION, RNA-dependent RNA polymerase, ... | | 著者 | Ferrero, D.S, Falqui, M, Verdaguer, N. | | 登録日 | 2021-05-21 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Snapshots of a Non-Canonical RdRP in Action.
Viruses, 13, 2021
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8C2P
 | | FMDV 3D polymerase in complex with 3B3 | | 分子名称: | Protein 3B-3, RNA-directed RNA polymerase 3D-POL | | 著者 | Ferrer-Orta, C, Veraguer, N. | | 登録日 | 2022-12-22 | | 公開日 | 2023-04-26 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Dual role of the foot-and-mouth disease virus 3B1 protein in the replication complex: As protein primer and as an essential component to recruit 3Dpol to membranes.
Plos Pathog., 19, 2023
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3QGD
 | | Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid and (2R)-4-(2,6-dimethoxypyrimidin-4-yl)-1-[(4-ethylphenyl)sulfonyl]-N-(4-methoxybenzyl)piperazine-2-carboxamide | | 分子名称: | (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, (2R)-4-(2,6-dimethoxypyrimidin-4-yl)-1-[(4-ethylphenyl)sulfonyl]-N-(4-methoxybenzyl)piperazine-2-carboxamide, RNA-directed RNA polymerase, ... | | 著者 | Sheriff, S. | | 登録日 | 2011-01-24 | | 公開日 | 2011-04-20 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.
Bioorg.Med.Chem.Lett., 21, 2011
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3QGF
 | | Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid and (2R)-4-(6-chloropyridazin-3-yl)-N-(4-methoxybenzyl)-1-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazine-2-carboxamide | | 分子名称: | (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, (2R)-4-(6-chloropyridazin-3-yl)-N-(4-methoxybenzyl)-1-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazine-2-carboxamide, RNA-directed RNA polymerase, ... | | 著者 | Sheriff, S. | | 登録日 | 2011-01-24 | | 公開日 | 2011-04-20 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.
Bioorg.Med.Chem.Lett., 21, 2011
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3QGG
 | | Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid and N-cyclopropyl-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide | | 分子名称: | (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, N-cyclopropyl-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide, RNA-directed RNA polymerase, ... | | 著者 | Sheriff, S. | | 登録日 | 2011-01-24 | | 公開日 | 2011-04-20 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | | 主引用文献 | Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.
Bioorg.Med.Chem.Lett., 21, 2011
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3QGE
 | | Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid and (2R)-4-(2,6-dimethoxypyrimidin-4-yl)-N-(4-methoxybenzyl)-1-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazine-2-carboxamide | | 分子名称: | (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, (2R)-4-(2,6-dimethoxypyrimidin-4-yl)-N-(4-methoxybenzyl)-1-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazine-2-carboxamide, RNA-directed RNA polymerase, ... | | 著者 | Sheriff, S. | | 登録日 | 2011-01-24 | | 公開日 | 2011-04-20 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.
Bioorg.Med.Chem.Lett., 21, 2011
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7YFE
 | | In situ structure of polymerase complex of mammalian reovirus in virion | | 分子名称: | Lambda-2 protein, Mu-2 protein, RNA (5'-R(P*AP*CP*GP*AP*UP*UP*AP*GP*C)-3'), ... | | 著者 | Bao, K.Y, Zhang, X.L, Li, D.Y, Zhu, P. | | 登録日 | 2022-07-08 | | 公開日 | 2023-03-29 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7YED
 | | In situ structure of polymerase complex of mammalian reovirus in the elongation state | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Lambda-2 protein, MAGNESIUM ION, ... | | 著者 | Bao, K.Y, Zhang, X.L, Li, D.Y, Zhu, P. | | 登録日 | 2022-07-05 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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