PDB: 1955 件ウェブページステータス検索Chemie searchBIRD

---

7NIR	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8191 core 分子名称: Nanobody8191 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-13 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (6.7 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NJ7	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8200 core 分子名称: Nb8200 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-16 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (4.82 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7DTE	SARS-CoV-2 RdRP catalytic complex with T33-1 RNA 分子名称: Non-structural protein 7, Non-structural protein 8, RNA (33-MER), ... 著者 Wang, Q, Gong, P. 登録日 2021-01-04 公開日 2021-10-20 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex. Cell Rep, 37, 2021
4OBC	Crystal structure of HCV polymerase NS5b genotype 2a JFH-1 isolate with the S15G, C223H, V321I resistance mutations against the guanosine analog GS-0938 (PSI-3529238) 分子名称: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... 著者 Edwards, T.E, Abendroth, J, Appleby, T.C. 登録日 2014-01-07 公開日 2014-09-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance. Antimicrob.Agents Chemother., 58, 2014
4AEX	HCV-JFH1 NS5B POLYMERASE STRUCTURE AT 2.4 ANGSTROM in a primitive orthorhombic space group 分子名称: PHOSPHATE ION, RNA-DIRECTED RNA POLYMERASE 著者 Caillet-Saguy, C, Bressanelli, S. 登録日 2012-01-12 公開日 2012-05-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Two Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405. J.Virol., 86, 2012
4E7A	Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin deletion bound to primer-template RNA with a 2',3'-ddC 分子名称: 5'-R(*CP*AP*UP*GP*GP*C)-D(P*(DOC))-3', RNA-directed RNA polymerase 著者 Edwards, T.E, Mosley, R.T. 登録日 2012-03-16 公開日 2012-04-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of hepatitis C virus polymerase in complex with primer-template RNA. J.Virol., 86, 2012
4AEP	HCV-JFH1 NS5B POLYMERASE STRUCTURE AT 1.8 ANGSTROM 分子名称: PHOSPHATE ION, RNA-DIRECTED RNA POLYMERASE 著者 Caillet-Saguy, C, Bressanelli, S. 登録日 2012-01-12 公開日 2012-05-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Two Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405. J.Virol., 86, 2012
4E78	Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin loop deletion bound to primer-template RNA with 3'-dG 分子名称: 5'-R(*U*AP*CP*CP*GP*(GDO))-3', PROTEIN (RNA-directed RNA polymerase) 著者 Edwards, T.E, Mosley, R.T. 登録日 2012-03-16 公開日 2012-04-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of hepatitis C virus polymerase in complex with primer-template RNA. J.Virol., 86, 2012
3GYN	Crystal structure of HCV NS5B polymerase with a novel monocyclic dihydropyridinone inhibitor 分子名称: N-{3-[(5R)-1-cyclopentyl-4-hydroxy-5-methyl-5-(3-methylbutyl)-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase 著者 Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. 登録日 2009-04-04 公開日 2009-12-08 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 19, 2009
3IGV	Crystal structure of HCV NS5B polymerase with a novel monocyclic dihydro-pyridinone inhibitor 分子名称: N-{3-[(6S)-6-ethyl-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-DIRECTED RNA POLYMERASE 著者 Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. 登録日 2009-07-28 公開日 2009-12-08 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 19, 2009
4NLD	Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with BMS-791325 also known as (1aR,12bS)-8-cyclohexyl-n-(dimethylsulfamoyl)-11-methoxy-1a-{[(1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide and 2-(4-fluorophenyl)-n-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide 分子名称: (1aR,12bS)-8-cyclohexyl-N-(dimethylsulfamoyl)-11-methoxy-1a-{[(1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide, 2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide, RNA-directed RNA polymerase, ... 著者 Sheriff, S. 登録日 2013-11-14 公開日 2014-03-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase. J.Med.Chem., 57, 2014
7NIL	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8190 core 分子名称: Nanobody8190 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-12 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (5.01 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NKC	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8207 分子名称: Nb8207, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-17 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (4.46 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NK8	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8205 core 分子名称: Nb8205, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-17 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (5.34 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NK4	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8203 core 分子名称: Nanobody 8203, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-17 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (5.32 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NKR	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8210 分子名称: Nb8210, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-18 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (5.6 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NKI	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8209 core 分子名称: Nb8209, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-18 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (4.67 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NKA	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8206 分子名称: NB8206, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-17 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (4.07 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NIK	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8189 core 分子名称: Nanobody8189 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-12 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (6.2 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NK6	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8204 分子名称: Nb8204, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-17 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (6.72 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NI0	1918 H1N1 Viral influenza polymerase heterotrimer - Replicase (class 3) 分子名称: Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3'), ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-11 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (3.32 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
4E76	Apo crystal structure of HCV NS5B genotype 2A JFH-1 isolate with beta hairpin loop deletion 分子名称: 1,2-ETHANEDIOL, RNA-directed RNA polymerase, SULFATE ION 著者 Edwards, T.E, Mosley, R.T. 登録日 2012-03-16 公開日 2012-04-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of hepatitis C virus polymerase in complex with primer-template RNA. J.Virol., 86, 2012
7NHC	1918 H1N1 Viral influenza polymerase heterotrimer - Endonuclease ordered (Class2b) 分子名称: Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3'), ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-10 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (2.87 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NHX	1918 H1N1 Viral influenza polymerase heterotrimer - full transcriptase (Class1) 分子名称: Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3'), ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-11 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NHA	1918 H1N1 Viral influenza polymerase heterotrimer - Endonuclease and priming loop ordered (Class2a) 分子名称: Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3'), ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-10 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (2.91 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022

<9101112131415161718192021222324>