8DB7

Adenosine/guanosine nucleoside hydrolase bound to a fragment inhibitor

Summary for 8DB7

Entry DOI	10.2210/pdb8db7/pdb
Descriptor	Inosine-uridine preferring nucleoside hydrolase family protein, GLYCEROL, N-(4-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine, ... (5 entities in total)
Functional Keywords	nucleoside, hydrolase, adenosine, guanosine, parasitic, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Trichomonas vaginalis
Total number of polymer chains	4
Total formula weight	134971.61
Authors	Muellers, S.N.,Allen, K.N.,Stockman, B.J. (deposition date: 2022-06-14, release date: 2022-09-07, Last modification date: 2024-04-03)
Primary citation	Muellers, S.N.,Nyitray, M.M.,Reynarowych, N.,Saljanin, E.,Benzie, A.L.,Schoenfeld, A.R.,Stockman, B.J.,Allen, K.N. Structure-Guided Insight into the Specificity and Mechanism of a Parasitic Nucleoside Hydrolase. Biochemistry, 61:1853-1861, 2022 Cited by PubMed: 35994320 DOI: 10.1021/acs.biochem.2c00361 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation