2L6T
| Efficacy of an HIV-1 entry inhibitor targeting the GP41 fusion peptide | 分子名称: | VIR-576 | 著者 | Forssmann, W, The, Y, Stoll, M, Adermann, K, Albrecht, U, Barlos, K, Busmann, A, Can les-Mayordomo, A, Gimenez-Gallego, G, Hirsch, J, Jimenez-Barbero, J, Meyer-Olson, D, Muench, J, Perez-Castells, J, Staendker, L, Kirchhoff, F, Schmidt, R.E. | 登録日 | 2010-11-24 | 公開日 | 2011-01-19 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Short-term monotherapy in HIV-infected patients with a virus entry inhibitor against the gp41 fusion peptide. Sci Transl Med, 2, 2010
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7U2U
| CRYSTAL STRUCTURE OF HIV-1 INTEGRASE COMPLEXED WITH Compound-2a AKA (2S)-2-(TERT-BUTOXY)-2-[7-(4,4-DIMETHYLPIPE RIDIN-1-YL)-8-{4-[2-(4-FLUOROPHENYL)ETHOXY]PHENYL}-2,5-DIM ETHYLIMIDAZO[1,2-A]PYRIDIN-6-YL]ACETIC ACID | 分子名称: | (2S)-tert-butoxy[(4S)-7-(4,4-dimethylpiperidin-1-yl)-8-{4-[2-(4-fluorophenyl)ethoxy]phenyl}-2,5-dimethylimidazo[1,2-a]pyridin-6-yl]acetic acid, Integrase, SULFATE ION | 著者 | Khan, J.A, lewis, H, Kish, K. | 登録日 | 2022-02-24 | 公開日 | 2022-06-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.839 Å) | 主引用文献 | Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors. Bioorg.Med.Chem., 67, 2022
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2LI7
| Solution Structure of CssII | 分子名称: | Beta-mammal toxin Css2 | 著者 | del Rio-Portilla, F, Saucedo, A.L, Corzo, G, Delepierre, M, Possani, L.D. | 登録日 | 2011-08-24 | 公開日 | 2012-02-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of native and recombinant expressed toxin CssII from the venom of the scorpion Centruroides suffusus suffusus, and their effects on Nav1.5 Sodium channels. Biochim.Biophys.Acta, 1824, 2012
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5JFE
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5JK7
| The X-ray structure of the DDB1-DCAF1-Vpr-UNG2 complex | 分子名称: | DNA damage-binding protein 1, Protein VPRBP, Protein Vpr, ... | 著者 | Calero, G, Ahn, J, Wu, Y. | 登録日 | 2016-04-26 | 公開日 | 2016-10-05 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | The DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction. Nat.Struct.Mol.Biol., 23, 2016
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6DRI
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6DB7
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5IVJ
| Linked KDM5A Jmj Domain Bound to the Inhibitor N11 [3-({1-[2-(4,4-difluoropiperidin-1-yl)ethyl]-5-fluoro-1H-indazol-3-yl}amino)pyridine-4-carboxylic acid] | 分子名称: | 3-({1-[2-(4,4-difluoropiperidin-1-yl)ethyl]-5-fluoro-1H-indazol-3-yl}amino)pyridine-4-carboxylic acid, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Horton, J.R, Cheng, X. | 登録日 | 2016-03-21 | 公開日 | 2016-07-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.569 Å) | 主引用文献 | Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol, 23, 2016
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7CDX
| Complex STRUCTURE OF A NOVEL VIRULENCE REGULATION FACTOR SghR with its effector sucrose | 分子名称: | LacI-type transcription factor, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | 著者 | Ye, F.Z, Wang, C, Yan, X.F, Zhang, L.H, Gao, Y.G. | 登録日 | 2020-06-20 | 公開日 | 2020-07-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.103 Å) | 主引用文献 | Structural basis of a novel repressor, SghR, controllingAgrobacteriuminfection by cross-talking to plants. J.Biol.Chem., 295, 2020
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5IX9
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7TTI
| Human KCC1 bound with VU0463271 In an outward-open state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-cyclopropyl-N-(4-methyl-1,3-thiazol-2-yl)-2-[(6-phenylpyridazin-3-yl)sulfanyl]acetamide, Solute carrier family 12 member 4 | 著者 | Zhao, Y.X, Cao, E.H. | 登録日 | 2022-02-01 | 公開日 | 2022-06-29 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of the human cation-chloride cotransport KCC1 in an outward-open state. Proc.Natl.Acad.Sci.USA, 119, 2022
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7CD8
| GFP-40/GFPuv complex, Form II | 分子名称: | GFP-40, Green fluorescent protein | 著者 | Yasui, N, Yamashita, A. | 登録日 | 2020-06-18 | 公開日 | 2021-01-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A sweet protein monellin as a non-antibody scaffold for synthetic binding proteins. J.Biochem., 169, 2021
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7CLJ
| Crystal structure of Thermoplasmatales archaeon heliorhodopsin E108D mutant | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, RETINAL, SULFATE ION, ... | 著者 | Tanaka, T, Shihoya, W, Yamashita, K, Nureki, O. | 登録日 | 2020-07-21 | 公開日 | 2020-09-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for unique color tuning mechanism in heliorhodopsin. Biochem.Biophys.Res.Commun., 533, 2020
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7TUH
| Crystal structure of anti-tapasin PaSta2-Fab | 分子名称: | PaSta2 Fab heavy chain, PaSta2 Fab kappa light chain | 著者 | Jiang, J, Natarajan, K, Taylor, D.K, Boyd, L.F, Margulies, D.H. | 登録日 | 2022-02-02 | 公開日 | 2022-09-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation. Nat Commun, 13, 2022
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6DEN
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7CT5
| S protein of SARS-CoV-2 in complex bound with T-ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Guo, L, Bi, W.W, Zhang, Y.Y, Yan, R.H, Li, Y.N, Zhou, Q, Dang, B.B. | 登録日 | 2020-08-18 | 公開日 | 2020-11-18 | 最終更新日 | 2021-02-10 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Engineered trimeric ACE2 binds viral spike protein and locks it in "Three-up" conformation to potently inhibit SARS-CoV-2 infection. Cell Res., 31, 2021
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5IH4
| Human Casein Kinase 1 isoform delta apo (kinase domain) | 分子名称: | Casein kinase I isoform delta, S,R MESO-TARTARIC ACID, SULFATE ION, ... | 著者 | Ursu, A, Illich, D.J, Takemoto, Y, Porfetye, A.T, Zhang, M, Brockmeyer, A, Janning, P, Watanabe, N, Osada, H, Vetter, I.R, Ziegler, S, Schoeler, H.R, Waldmann, H. | 登録日 | 2016-02-29 | 公開日 | 2016-04-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chem Biol, 23, 2016
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5IG5
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7TTH
| Human potassium-chloride cotransporter 1 in inward-open state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, POTASSIUM ION, Solute carrier family 12 member 4 | 著者 | Zhao, Y.X, Cao, E.H. | 登録日 | 2022-02-01 | 公開日 | 2022-06-29 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Structure of the human cation-chloride cotransport KCC1 in an outward-open state. Proc.Natl.Acad.Sci.USA, 119, 2022
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5IGR
| Macrolide 2'-phosphotransferase type I - complex with GDP and oleandomycin | 分子名称: | (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-HYDROXY-5,7,8,11,13,15-HEXAMETHYL-4,10-DIOXO-14-{[3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSYL]OXY}-1,9-DIOXASPIRO[2.13]HEXADEC-12-YL 2,6-DIDEOXY-3-O-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSIDE, AMMONIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Berghuis, A.M, Fong, D.H. | 登録日 | 2016-02-28 | 公開日 | 2017-04-26 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance. Structure, 25, 2017
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6DJH
| Crystal structure of Tdp1 catalytic domain in complex with compound XZ515 | 分子名称: | 1,2-ETHANEDIOL, 8-bromo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Tyrosyl-DNA phosphodiesterase 1 | 著者 | Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. | 登録日 | 2018-05-25 | 公開日 | 2019-05-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.918 Å) | 主引用文献 | Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening. Nucleic Acids Res., 47, 2019
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6DME
| ppGpp Riboswitch bound to ppGpp, thallium acetate structure | 分子名称: | GUANOSINE-5',3'-TETRAPHOSPHATE, MAGNESIUM ION, THALLIUM (I) ION, ... | 著者 | Peselis, A, Serganov, A. | 登録日 | 2018-06-05 | 公開日 | 2018-11-14 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.702 Å) | 主引用文献 | ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands. Nat. Chem. Biol., 14, 2018
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6DC0
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2OJT
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6DEL
| Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl | 分子名称: | (3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE, (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate, 2-[[[[(4-CHLORO-6-METHOXY-2-PYRIMIDINYL)AMINO]CARBONYL]AMINO]SULFONYL]BENZOIC ACID ETHYL ESTER, ... | 著者 | Garcia, M.D, Guddat, L.W. | 登録日 | 2018-05-12 | 公開日 | 2018-09-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.119 Å) | 主引用文献 | Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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