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6DEL

Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl

Summary for 6DEL
Entry DOI10.2210/pdb6del/pdb
DescriptorAcetolactate synthase, POTASSIUM ION, MAGNESIUM ION, ... (9 entities in total)
Functional Keywordsahas, acetohydroxyacid synthase, acetolactate synthase, herbicide, thiamin diphosphate, fad, transferase, chlorimuron ethyl, sulfonylurea, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Total number of polymer chains1
Total formula weight76479.78
Authors
Garcia, M.D.,Guddat, L.W. (deposition date: 2018-05-12, release date: 2018-09-26, Last modification date: 2023-10-11)
Primary citationGarcia, M.D.,Chua, S.M.H.,Low, Y.S.,Lee, Y.T.,Agnew-Francis, K.,Wang, J.G.,Nouwens, A.,Lonhienne, T.,Williams, C.M.,Fraser, J.A.,Guddat, L.W.
Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.
Proc. Natl. Acad. Sci. U.S.A., 115:E9649-E9658, 2018
Cited by
PubMed: 30249642
DOI: 10.1073/pnas.1809422115
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.119 Å)
Structure validation

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