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6DEL

Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A0003824molecular_functioncatalytic activity
A0003984molecular_functionacetolactate synthase activity
A0005948cellular_componentacetolactate synthase complex
A0006412biological_processtranslation
A0008652biological_processamino acid biosynthetic process
A0009082biological_processbranched-chain amino acid biosynthetic process
A0009097biological_processisoleucine biosynthetic process
A0009099biological_processvaline biosynthetic process
A0016740molecular_functiontransferase activity
A0030150biological_processprotein import into mitochondrial matrix
A0030976molecular_functionthiamine pyrophosphate binding
A0046872molecular_functionmetal ion binding
A0050660molecular_functionflavin adenine dinucleotide binding
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue K A 701
ChainResidue
AGLN339
AASP346
AGLN502
APHE504
AHOH869
AHOH1228

site_idAC2
Number of Residues6
Detailsbinding site for residue MG A 702
ChainResidue
ATP9705
AG8G706
AHOH887
AASP546
AASN573
AGLU575

site_idAC3
Number of Residues15
Detailsbinding site for residue CIE A 703
ChainResidue
AGLY112
AALA113
APRO188
APHE197
AGLN198
ALYS247
AMET350
AASP375
AARG376
AMET578
ATRP582
AALA653
AFAD704
AFMT707
AHOH832

site_idAC4
Number of Residues37
Detailsbinding site for residue FAD A 704
ChainResidue
APHE197
AARG237
AGLY303
AALA304
AGLY305
AASN308
ATHR330
ALEU331
AGLN332
ALEU348
AGLY349
AMET350
AHIS351
AGLY370
AALA371
AARG372
AASP374
AARG376
AVAL377
AGLU403
AILE404
AASN408
AGLY421
AASP422
AVAL423
AGLN497
AMET498
AGLY516
AGLY517
AMET578
ACIE703
AHOH801
AHOH806
AHOH877
AHOH894
AHOH939
AHOH1147

site_idAC5
Number of Residues26
Detailsbinding site for residue TP9 A 705
ChainResidue
AALA110
AGLU135
APRO161
AASN165
AGLN198
AVAL493
AGLY494
AGLN495
AHIS496
AGLY519
AMET521
AGLY545
AASP546
AALA547
ASER548
AASN573
AGLU575
AGLN576
AGLY577
AMET578
AVAL579
AMG702
AG8G706
AFMT707
AHOH887
AHOH1073

site_idAC6
Number of Residues28
Detailsbinding site for residue G8G A 706
ChainResidue
AHIS496
AGLY519
AMET521
AGLY545
AASP546
AALA547
ASER548
AMET551
AASN573
AGLU575
AGLN576
AGLY577
AMET578
AVAL579
AMG702
ATP9705
AFMT707
AHOH887
AHOH1073
AALA110
AGLY111
AGLU135
APRO161
AASN165
AGLN198
AVAL493
AGLY494
AGLN495

site_idAC7
Number of Residues5
Detailsbinding site for residue FMT A 707
ChainResidue
AGLY112
AGLN198
ACIE703
ATP9705
AG8G706

Functional Information from PROSITE/UniProt
site_idPS00187
Number of Residues20
DetailsTPP_ENZYMES Thiamine pyrophosphate enzymes signature. IGaqvakPdaivIdIdGDAS
ChainResidueDetails
AILE529-SER548

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PDB entries from 2024-07-17

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