PDB: 45459 件ウェブページステータス検索Chemie searchBIRD

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5J4W	DIY G-Quadruplexes: Solution structure of d(GGTTTGGTTTTGGTTGG) in sodium 分子名称: DNA (5'-D(*GP*GP*TP*TP*TP*GP*GP*TP*TP*TP*TP*GP*GP*TP*TP*GP*G)-3') 著者 Dvorkin, S.A, Webba da Silva, M. 登録日 2016-04-01 公開日 2017-04-12 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Encoding canonical DNA quadruplex structure. Sci Adv, 4, 2018
6Q4A	CDK2 in complex with FragLite14 分子名称: 5-iodanylpyrimidine, CYCLIN-DEPENDENT KINASE 2 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
6Q4I	CDK2 in complex with FragLite35 分子名称: 2-[4-[(2-oxidanylidene-3~{H}-pyridin-4-yl)oxy]phenyl]ethanoic acid, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.11 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
6D2U	Solution structure of a ultra-high affinity macrocycle bound to HIV-1 TAR RNA 分子名称: DAB-VAL-ARG-THR-ARG-LYS-GLY-ARG-ARG-ILE-NOR-ILE-DPR-PRO, RNA (29-MER) 著者 Shortridge, M.D, Varani, G. 登録日 2018-04-13 公開日 2018-12-12 最終更新日 2023-11-15 実験手法 SOLUTION NMR 主引用文献 An ultra-high affinity ligand of HIV-1 TAR reveals the RNA structure recognized by P-TEFb. Nucleic Acids Res., 47, 2019
6G88	Crystal structure of Enterococcus Faecium D63r Penicillin-Binding protein 5 (PBP5fm) 分子名称: (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyrrolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Low affinity penicillin-binding protein 5 (PBP5), SULFATE ION 著者 Sauvage, E, El Gachi, M, Herman, R, Kerff, F, Charlier, P. 登録日 2018-04-08 公開日 2019-04-24 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural basis of inactivation of Enterococcus faecium penicillin binding protein 5 by ceftobiprole. To Be Published
6Q4C	CDK2 in complex with FragLite16 分子名称: 4-bromanyl-1,8-naphthyridine, Cyclin-dependent kinase 2 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
6Q4F	CDK2 in complex with FragLite32 分子名称: Cyclin-dependent kinase 2, PYRIDINE-2,6-DIAMINE 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.21 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
6Q57	X-ray crystal structure of the tetrahydrofolate riboswitch aptamer bound to 5-deazatetrahydropterin 分子名称: 5-deazatetrahydropterin, MAGNESIUM ION, tetrahydrofolate riboswitch aptamer 著者 Dunstan, M.S. 登録日 2018-12-07 公開日 2019-12-18 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 Tetrahydrofolate Riboswitches Provide Distinct Genetic Outputs to Synthetic and Natural Signals. To Be Published
8AJ8	Structure of p110 gamma bound to the p84 regulatory subunit 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Phosphoinositide 3-kinase regulatory subunit 6 著者 Burke, J.E, Williams, R.L, Zhang, X. 登録日 2022-07-27 公開日 2023-03-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (8.5 Å) 主引用文献 Molecular basis for differential activation of p101 and p84 complexes of PI3K gamma by Ras and GPCRs. Cell Rep, 42, 2023
5JFE	Flavin-dependent thymidylate synthase with H2-dUMP 分子名称: 1,2-ETHANEDIOL, 2'-deoxy-5'-uridylic acid, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Sapra, A, Stuckey, J, Palfey, B. 登録日 2016-04-19 公開日 2017-04-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Evaluating H2-dUMP as an Intermediate in the oxidation of Flavin-dependent Thymidylate Synthase To Be Published
5JK7	The X-ray structure of the DDB1-DCAF1-Vpr-UNG2 complex 分子名称: DNA damage-binding protein 1, Protein VPRBP, Protein Vpr, ... 著者 Calero, G, Ahn, J, Wu, Y. 登録日 2016-04-26 公開日 2016-10-05 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.49 Å) 主引用文献 The DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction. Nat.Struct.Mol.Biol., 23, 2016
6Z5N	DnaJB1 JD-GF 分子名称: DnaJ homolog subfamily B member 1 著者 Avraham-Abayev, M, London, N, Rosenzweig, R. 登録日 2020-05-27 公開日 2020-11-18 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 HSP40 proteins use class-specific regulation to drive HSP70 functional diversity. Nature, 587, 2020
6Z40	NMR solution structure of the carbohydrate-binding module family 5 (CBM5) from Cellvibrio japonicus CjLPMO10A 分子名称: Carbohydrate binding protein, putative, cpb33A 著者 Madland, E, Aachmann, F.L, Courtade, G. 登録日 2020-05-22 公開日 2021-05-05 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Structural and functional variation of chitin-binding domains of a lytic polysaccharide monooxygenase from Cellvibrio japonicus. J.Biol.Chem., 297, 2021
6GB6	Structure of H-2Kb with dipeptide GL 分子名称: Beta-2-microglobulin, GLYCEROL, GLYCINE, ... 著者 Hafstrand, I, Sandalova, T, Achour, A. 登録日 2018-04-13 公開日 2019-03-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin. Proc.Natl.Acad.Sci.USA, 116, 2019
5IVJ	Linked KDM5A Jmj Domain Bound to the Inhibitor N11 [3-({1-[2-(4,4-difluoropiperidin-1-yl)ethyl]-5-fluoro-1H-indazol-3-yl}amino)pyridine-4-carboxylic acid] 分子名称: 3-({1-[2-(4,4-difluoropiperidin-1-yl)ethyl]-5-fluoro-1H-indazol-3-yl}amino)pyridine-4-carboxylic acid, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Horton, J.R, Cheng, X. 登録日 2016-03-21 公開日 2016-07-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.569 Å) 主引用文献 Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol, 23, 2016
6BR5	N2 neuraminidase in complex with a novel antiviral compound 分子名称: (1R)-4-acetamido-1,5-anhydro-3-carbamimidamido-2,3,4-trideoxy-1-sulfo-D-glycero-D-galacto-octitol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Li, L.H, Ve, T, Pascolutti, M, Hadhazi, A, Bailly, B, Thomson, R.J, Gao, G.F, von Itzstein, M. 登録日 2017-11-30 公開日 2018-03-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.0379076 Å) 主引用文献 A Sulfonozanamivir Analogue Has Potent Anti-influenza Virus Activity. ChemMedChem, 13, 2018
6GBQ	Crystal Structure of the oligomerization domain of Vp35 from Reston virus 分子名称: Polymerase cofactor VP35 著者 Zinzula, L, Nagy, I, Orsini, M, Weyher-Stingl, E, Baumeister, W, Bracher, A. 登録日 2018-04-16 公開日 2018-10-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Structures of Ebola and Reston Virus VP35 Oligomerization Domains and Comparative Biophysical Characterization in All Ebolavirus Species. Structure, 27, 2019
6PBT	Pseudopaline Dehydrogenase with (R)-Pseudopaline Soaked 2 hours 分子名称: 1,2-ETHANEDIOL, N-[(3S)-3-amino-3-carboxypropyl]-L-histidine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 McFarlane, J.S, Lamb, A.L. 登録日 2019-06-14 公開日 2019-10-30 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Staphylopine and pseudopaline dehydrogenase from bacterial pathogens catalyze reversible reactions and produce stereospecific metallophores. J.Biol.Chem., 294, 2019
5IX9	Cell surface anchoring domain 分子名称: Antifreeze protein 著者 Guo, S, Langelaan, D. 登録日 2016-03-23 公開日 2017-06-28 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structure of a 1.5-MDa adhesin that binds its Antarctic bacterium to diatoms and ice. Sci Adv, 3, 2017
8AUP	Structure of hARG1 with a novel inhibitor. 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-[(1~{R},3~{R},4~{S})-3-azanyl-3-carboxy-4-[(dimethylamino)methyl]cyclohexyl]ethyl-$l^{3}-oxidanyl-bis(oxidanyl)boron, Arginase-1, ... 著者 Napiorkowska-Gromadzka, A, Nowak, E, Nowotny, M. 登録日 2022-08-25 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy. Mol.Cancer Ther., 22, 2023
6ZSL	Crystal structure of the SARS-CoV-2 helicase at 1.94 Angstrom resolution 分子名称: PHOSPHATE ION, SARS-CoV-2 helicase NSP13, ZINC ION 著者 Newman, J.A, Yosaatmadja, Y, Douangamath, A, Arrowsmith, C.H, von Delft, F, Edwards, A, Bountra, C, Gileadi, O. 登録日 2020-07-15 公開日 2020-07-29 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase. Nat Commun, 12, 2021
8AFA	Cryo-EM structure of a substrate-bound glutamate transporter homologue GltTk encapsulated within a nanodisc 分子名称: ASPARTIC ACID, Proton/glutamate symporter, SDF family 著者 Whittaker, J.J, Guskov, A. 登録日 2022-07-16 公開日 2023-04-05 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.25 Å) 主引用文献 Mutation in glutamate transporter homologue GltTk provides insights into pathologic mechanism of episodic ataxia 6. Nat Commun, 14, 2023
6G7J	Retinal isomerization in bacteriorhodopsin revealed by a femtosecond X-ray laser: 457-646 fs state structure 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, Bacteriorhodopsin, ... 著者 Nogly, P, Weinert, T, James, D, Cabajo, S, Ozerov, D, Furrer, A, Gashi, D, Borin, V, Skopintsev, P, Jaeger, K, Nass, K, Bath, P, Bosman, R, Koglin, J, Seaberg, M, Lane, T, Kekilli, D, Bruenle, S, Tanaka, T, Wu, W, Milne, C, White, T, Barty, A, Weierstall, U, Panneels, V, Nango, E, Iwata, S, Hunter, M, Schapiro, I, Schertler, G, Neutze, R, Standfuss, J. 登録日 2018-04-06 公開日 2018-06-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser. Science, 361, 2018
8AV2	Crystal structure for the FnIII module of mouse LEP-R in complex with the anti-LEP-R nanobody VHH-4.80 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin receptor, SULFATE ION, ... 著者 Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. 登録日 2022-08-26 公開日 2023-04-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
5IW6	anti-CD20 monoclonal antibody Fc fragment 分子名称: Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Tang, C, Chen, Z. 登録日 2016-03-22 公開日 2017-03-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Structure of anti-CD20 monoclonal antibody Fc fragment at 2.34 Angstroms resolution To Be Published

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