6D2U

Solution structure of a ultra-high affinity macrocycle bound to HIV-1 TAR RNA

Summary for 6D2U

• Entry DOI: 10.2210/pdb6d2u/pdb
• NMR Information: BMRB: 30452
• Descriptor: DAB-VAL-ARG-THR-ARG-LYS-GLY-ARG-ARG-ILE-NOR-ILE-DPR-PRO, RNA (29-MER) (2 entities in total)
• Functional Keywords: macrocycle inhibitor, complex, hiv-1 tar, tat, p-tefb, rna, peptide-rna complex, peptide/rna
• Biological source: synthetic construct; More
• Total number of polymer chains: 2
• Total formula weight: 11004.64

Authors

Shortridge, M.D.,Varani, G. (deposition date: 2018-04-13, release date: 2018-12-12, Last modification date: 2023-11-15)

• Primary citation: Shortridge, M.D.,Wille, P.T.,Jones, A.N.,Davidson, A.,Bogdanovic, J.,Arts, E.,Karn, J.,Robinson, J.A.,Varani, G.; An ultra-high affinity ligand of HIV-1 TAR reveals the RNA structure recognized by P-TEFb.; Nucleic Acids Res., 47:1523-1531, 2019; PubMed: 30481318; DOI: 10.1093/nar/gky1197

Experimental method

SOLUTION NMR